1 |
Sodium Thiosulfate for Protection Against Cisplatin-Induced Hearing Loss. |
To investigate whether the late administration for Sodium Thiosulfate would reduce the incidence and severity of cisplatin-induced hearing loss. |
Brock et al. (2018)BROCK, P.R., MAIBACH, R., CHILDS, M., RAJPUT, K., ROEBUCK, D., SULLIVAN, M.J., LAITHIER, V., RONGHE, M., DALL’IGNA, P., HIYAMA, E., BRICHARD, B., SKEEN, J., MATEOS, M.E., CAPRA, M., RANGASWAMI, A.A., ANSARI, M., RECHNITZER, C., VEAL, G.J., COVEZZOLI, A., BRUGIÈRES, L., PERILONGO, G., CZAUDERNA, P., MORLAND, B. and NEUWELT, E.A., 2018. Sodium thiosulfate for protection from cisplatin-induced hearing loss. The New England Journal of Medicine, vol. 378, no. 25, pp. 2376-2385. http://doi.org/10.1056/NEJMoa1801109. PMid:29924955. http://doi.org/10.1056/NEJMoa1801109...
, United Kingdom. |
2 |
The chemopreventive effect of Ginkgo Biloba 761 extract against cisplatin-induced ototoxicity: a pilot study. |
To elucidate the role of Ginkgo Biloba 761 in preventing damage to outer hair cells caused by cisplatin therapy in cancer patients through Distortion Product Otoacoustic Emissions. |
Dias et al. (2015)DIAS, M.A., SAMPAIO, A.L., VENOSA, A.R., MENESES, E.A. and OLIVEIRA, C.A., 2015. The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study. The International Tinnitus Journal, vol. 19, no. 2, pp. 12-19. http://doi.org/10.5935/0946-5448.20150003. PMid:27186927. http://doi.org/10.5935/0946-5448.2015000...
, Brazil. |
3 |
Are Ginkgo Biloba and Lycopene effective against cisplatin-induced ototoxicity? |
Investigate the protective effects of Lycopene and Ginkgo Biloba on cisplatin-induced ototoxicity and compare their advantages to each other |
Esen et al. (2018)ESEN, E., ÖZDOĞAN, F., GÜRGEN, S.G., ÖZEL, H.E., BAŞER, S., GENÇ, S. and SELÇUK, A., 2018. Ginkgo biloba and Lycopene are effective on cisplatin induced ototoxicity? The Journal of International Advanced Otology, vol. 14, no. 1, pp. 22-26. http://doi.org/10.5152/iao.2017.3137. PMid:28639555. http://doi.org/10.5152/iao.2017.3137...
, Turkiye. |
4 |
Amifostine protects against cisplatin-induced ototoxicity in children with medium-risk medulloblastoma. |
To investigate the ability of Amifostine to protect children receiving a high-dose cisplatin-based regimen against severe ototoxicity, defined as ototoxicity ≥ grade 3 that requires hearing aids in at least one ear, next to one year the start of treatment. |
Fouladi et al. (2008)FOULADI, M., CHINTAGUMPALA, M., ASHLEY, D., KELLIE, S., GURURANGAN, S., HASSALL, T., GRONEWOLD, L., STEWART, C.F., WALLACE, D., BRONISCER, A., HALE, G.A., KASOW, K.A., MERCHANT, T.E., MORRIS, B., KRASIN, M., KUN, L.E., BOYETT, J.M. and GAJJAR, A., 2008. Amifostine protects against cisplatin-induced ototoxicity in children with average-risk medulloblastoma. Journal of Clinical Oncology, vol. 26, no. 22, pp. 3749-3755. http://doi.org/10.1200/JCO.2007.14.3974. PMid:18669462. http://doi.org/10.1200/JCO.2007.14.3974...
, Tennessee. |
5 |
Effects of Sodium Thiosulfate vs. Observation on the Development of Cisplatin-Induced Hearing Loss in Children with Cancer: Results from the ACCL0431 Pediatric Oncology Group Randomized Clinical Trial. |
Compare the proportional incidence of post-treatment cisplatin-induced hearing loss between those randomized to receive or not receive Sodium Thiosulfate. |
Freyer et al. (2017)FREYER, D.R., CHEN, L., KRAILO, M.D., KNIGHT, K., VILLALUNA, D., BLISS, B., POLLOCK, B.H., RAMDAS, J., LANGE, B., VAN HOFF, D., VANSOELEN, M.L., WIERNIKOWSKI, J., NEUWELT, E.A. and SUNG, L., 2017. Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer: results from the children’s oncology group ACCL0431 randomised clinical trial. The Lancet. Oncology, vol. 18, no. 1, pp. 63-74. http://doi.org/10.1016/S1470-2045(16)30625-8. PMid:27914822. http://doi.org/10.1016/S1470-2045(16)306...
, California. |
6 |
Evaluation of Amifostine for Protection Against Severe Cisplatin-Induced Hearing Loss in Children Treated for Medium or High-Risk Medulloblastoma. |
Evaluation for Amifostine for Protection Against Severe Cisplatin-Induced Hearing Loss in Children Treated to Medium or High-Risk Medulloblastoma. |
Gurney et al. (2014)GURNEY, J., BASS, J.K., ONAR-THOMAS, A., HUANG, J., CHINTAGUMPALA, M., BOUFFET, E., HASSALL, T., GURURANGAN, S., HEATH, J.A., KELLIE, S., COHN, R., FISHER, M.J., PANANDIKER, A.P., MERCHANT, T.E., SRINIVASAN, A., WETMORE, C., QADDOUMI, I., STEWART, C.F., ARMSTRONG, G.T., BRONISCER, A. and GAJJAR, A., 2014. Evaluation of amifostine for protection against cisplatin-induced serious hearing loss in children treated for average-risk or high-risk medulloblastoma. Neuro-Oncology, vol. 16, no. 6, pp. 848-855. http://doi.org/10.1093/neuonc/not241. PMid:24414535. http://doi.org/10.1093/neuonc/not241...
, Tennessee. |
7 |
Amifostine Otoprotection Against Cisplatin Ototoxic Effects: Study in Albino Guinea Pigs Using Distortion Product Otoacoustic Emissions and Scanning Electron Microscopy. |
Assessing the Potential Otoprotective Effect of Amifostine in Cisplatin Treatment through Distortion Product Otoacoustic Emissions (DPOAE) and Scanning Electron Microscopy (SEM). |
Hyppolito et al. (2005)HYPPOLITO, M.A., DE OLIVEIRA, A.A., LESSA, R.M. and ROSSATO, M., 2005. Amifostineotoprotection to cisplatin ototoxicity: a guinea pig study using otoacoustic emission distortion products (DPOEA) and scanning electron microscopy. Revista Brasileira de Otorrinolaringologia, vol. 71, no. 3, pp. 268-273. PMid:16446928., Brazil. |
8 |
Amifostine does not prevent platinum-induced hearing loss associated with the treatment of children with hepatoblastoma. A report from the Intergroup Hepatoblastoma Study P9645 as part of the Children's Oncology Group. |
To determine whether Amifostine is effective in reducing toxicities associated with the administration of platinum-containing regimens to young people with hepatoblastoma. |
Katzenstein et al. (2009)KATZENSTEIN, H., CHANG, K.W., KRAILO, M., CHEN, Z., FINEGOLD, M.J., ROWLAND, J., REYNOLDS, M., PAPPO, A., LONDON, W.B. and MALOGOLOWKIN, M., 2009. Amifostine does not prevent platinum-induced hearing loss associated with the treatment of children with hepatoblastoma. A report of the Intergroup Hepatoblastoma Study P9645 as a part of the Children’s Oncology Group. Cancer, vol. 115, no. 24, pp. 5828-5835. http://doi.org/10.1002/cncr.24667. PMid:19813275. http://doi.org/10.1002/cncr.24667...
, California. |
9 |
Polidatina activates the Nrf2/HO-1 signaling pathway to protect against cisplatin-induced hearing loss in guinea pigs. |
Exploring the effects of Polidatina on cisplatin-induced hearing loss and attempting to unravel the underlying mechanism. |
Li et al. (2022)LI, D., ZHAO, H., XU, P., LIN, Q., ZHAO, T., LI, C., CUI, Z.K. and TIAN, G., 2022. Polydatin activates the Nrf2/HO-1 signaling pathway to protect cisplatin-induced hearing loss in guinea pigs. Frontiers in Pharmacology, vol. 13, pp. 887833. PMid:35991886., China. |
10 |
Amifostine doesn't protect against cisplatin ototoxicity at high doses combined with etoposide and bleomycin in pediatric germ cell tumors. |
To determine if pretreatment with Amifostine reduced the significant ototoxicity associated with drugs while maintaining its survival advantage. |
Marina et al. (2005)MARINA, N., CHANG, K.W., MALOGOLOWKIN, M., LONDON, W.B., FRAZIER, A.L., WOMER, R.B., RESCORLA, F., BILLMIRE, D.F., DAVIS, M.M., PERLMAN, E.J., GILLER, R., LAUER, S.J. and OLSON, T.A., 2005. Amifostine does not protect against the ototoxicity of high-dose cisplatin combined with etoposide and bleomycin in pediatric germ-cell tumors. Cancer, vol. 104, no. 4, pp. 841-847. http://doi.org/10.1002/cncr.21218. PMid:15999362. http://doi.org/10.1002/cncr.21218...
, California. |
11 |
Transtympanic injections of N-acetylcysteine and Dexamethasone for the prevention of cisplatin-induced ototoxicity: a double-blind randomized clinical trial. |
Comparing the positive effects of intratympanic injection for N-acetylcysteine and Dexamethasone in preventing cisplatin-induced ototoxicity. |
Sarafraz et al. (2018)SARAFRAZ, Z., AHMADI, A. and DANESHI, A., 2018. Transtympanic injections of N-acetylcysteine and dexamethasone for prevention of cisplatin-induced ototoxicity: double blind randomized clinical Trial. The International Tinnitus Journal, vol. 22, no. 1, pp. 40-45. http://doi.org/10.5935/0946-5448.20180007. PMid:29993216. http://doi.org/10.5935/0946-5448.2018000...
, Iran. |
12 |
Effect of Genistein on cisplatin-induced ototoxicity and oxidative stress. |
Evaluate the otoprotective effect of Genistein against cisplatin in rats. |
Tan et al. (2022)TAN, M., TOPLU, Y., VARAN, E., SAPMAZ, E., ÖZHAN, O., PARLAKPINAR, H. and POLAT, A., 2022. The effect of genistein on cisplatininduced ototoxicity and oxidative stress. Revista Brasileira de Otorrinolaringologia, vol. 88, no. 1, pp. 105-111. PMid:34602350., Turkiye. |