Havelek et al. (2017)HAVELEK, R., MUTHNA, D., TOMSIK, P., KRALOVEC, K., SEIFRTOVA, M., CAHLIKOVA, L., HOSTALKOVA, A., SAFRATOVA, M., PERWEIN, M., CERMAKOVA, E. and REZACOVA, M., 2017. Anticancer potential of Amaryllidaceae alkaloids evaluated by screening with a panel of human cells, real-time cellular analysis and Ehrlich tumor-bearing mice. Chemico-Biological Interactions, vol. 275, pp. 121-132. http://dx.doi.org/10.1016/j.cbi.2017.07.018. PMid:28756149. http://dx.doi.org/10.1016/j.cbi.2017.07....
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The anticancer potential of Amaryllidaceae alkaloids was assessed by screening with a panel of human cells, real-time cell analysis, and Ehrlich tumor-bearing mice. |
Zephyranthes robusta (Herb.ex Sweet) Baker; Chlidanthus fragrans Herb; Nerine bowdenii W.Watson; Narcissus poeticus L. |
Hemantamine and lycorine can inhibit cell proliferation of 16 human cancer cell lines from different tissue origins. |
Aziz et al. (2014)AZIZ, A., SARWAR RAJU, G., DAS, A., AHMED, J. and MOGHAL, M.M., 2014. Evaluation of in vitro anthelmintic activity, total phenolic content and cytotoxic activity of Crinum latifolium L. (Family: amaryllidaceae). Advanced Pharmaceutical Bulletin, vol. 4, no. 1, pp. 15-19. http://dx.doi.org/10.5681/apb.2014.003. PMid:24409404. http://dx.doi.org/10.5681/apb.2014.003...
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The anthelmintic activity of Crinum latifolium leaves was assessed on Pheritima posthuma. Cytotoxicity was evaluated using the brine shrimp model. |
Crinum latifolium L. |
The crude methanol extract from leaves presented a mild anthelmintic activity compared to albendazol and low toxicity to Artemia salina
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Tijani et al. (2012)TIJANI, A.Y., ADEOLA, S.O., JAIYEOBA, G.L., ADAMU, M., CHRISTIANAH, I. and CHINDO, B., 2012. Wound healing activity of Crinum zeylanicum L. (Amaryllidaceae). Phytopharmacology, vol. 3, no. 2, pp. 319-325.
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Evaluate the wound healing activity of an ointment containing Crinum zeylanicum bulbs extract |
Crinum zeylanicum (L.) L. |
The ointment did not present acute dermal toxicity and promoted wound retraction and epithelization in rats, accelerating the healing process. |
Masi et al. (2019)MASI, M., VAN SLAMBROUCK, S., GUNAWARDANA, S., VAN RENSBURG, M.J., JAMES, P.C., MOCHEL, J.G., HELISO, P.S., ALBALAWI, A.S., CIMMINO, A., VAN OTTERLO, W.A.L., KORNIENKO, A., GREEN, I.R. and EVIDENTE, A., 2019. Alkaloids isolated from Haemanthus humilis Jacq., an indigenous South African Amaryllidaceae: anticancer activity of coccinine and montanine. South African Journal of Botany, vol. 126, pp. 277-281. http://dx.doi.org/10.1016/j.sajb.2019.01.036. http://dx.doi.org/10.1016/j.sajb.2019.01...
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Non-alkaloid compounds from Crinum biflorum bulbs were tested for cytotoxicity |
Crinum biflorum Rottb. |
Flavonoids and coumarine derivatives were tested against HeLa and A431 cancer cell lines and were active. N-p-coumaroyltyramine was toxic to cancer cells and protected HaCat cells against oxidative stress.The flavonoid derivatives presented AChE inibition activity and the coumarin derivative presented α-amylase and β-glucosidase inhibition. |
Omoruyi et al. (2021b)OMORUYI, S.I., IBRAKAW, A.S., EKPO, O.E., BOATWRIGHT, J.S., CUPIDO, C.N. and HUSSEIN, A.A., 2021b. Neuroprotective activities of Crossyne flava bulbs and Amaryllidaceae alkaloids: implications for Parkinson’s disease. Molecules, vol. 26, no. 13, pp. 3990. http://dx.doi.org/10.3390/molecules26133990. PMid:34208814. http://dx.doi.org/10.3390/molecules26133...
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The potential in vitro neuroprotection, antioxidant activities and cytotoxicity of Crossyne flava extract and isolated alkaloids |
Crossyne flava (W.F.Baker ex Snijman) D.Müll.-Doblies & U.Müll.-Doblies |
The crude extract of bulbs,pancratinine B, buphanidrine, and buphanisine did not interfere in the SH-SY5Y cells viability; epibuphanisine was cytotoxic in high concentration. The extract and all compounds presented neuroprotection by attenuating ATP levels in the cells and inhibited MPP+-induced apoptosis |
Tayoub et al. (2018)TAYOUB, G., AL-ODAT, M., AMER, A., ALJAPAWE, A. and EKHTIAR, A., 2018. Antiproliferative Effects of Pancratium Maritimum Extracts on Normal and Cancerous Cells. Iranian Journal of Medical Sciences, vol. 43, no. 1, pp. 52-64. PMid:29398752.
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Anti-proliferative effects of Pancratium maritimum extracts on MDA-MB-321 cells |
Pancratium maritimum L |
Extracts from bulbs and leaves of Pancratium maritimum inhibit MDA-MB-321 cell proliferation, through cell arrest at S and G2/M phases. The extracts also affected Cyclin B1, Bcl-2, and Ki67 expression |
Berkov et al. (2021)BERKOV, S., PECHLIVANOVA, D., DENEV, R., NIKOLOVA, M., GEORGIEVA, L., SIDJIMOVA, B., BAKALOV, D., TAFRADJIISKA, R., STOYNEV, A., MOMEKOV, G. and BASTIDA, J., 2021. GC-MS analysis of Amaryllidaceae and Sceletium-type alkaloids in bioactive fractions from Narcissus cv. Hawera. Rapid Communications in Mass Spectrometry, vol. 35, no. 14, e9116. http://dx.doi.org/10.1002/rcm.9116. PMid:33928691. http://dx.doi.org/10.1002/rcm.9116...
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The alkaloid-rich (without lycorine) fraction of Narcissus cv. Hawera showed in vitro AchE inhibition, cytotoxic activities, and in vivo anxiolytic and anti-depressant-like activities in mice. |
Narcissus cv. Hawera |
The alkaloid-rich fraction anxiolytic effect is sex-dependent and was observed only in male mice, while female mice did not change their anxiety-like behavior after treatment. In the anti-depressant-like assay, female mice were more sensitive to the alkaloid-rich fraction than male mice. Male mice needed a higher dose than used for female mice to decrease the immobility time. The alkaloid-rich fraction inhibited HL-60 and BV-173 cell lines growth, but only a highest dose was able to inhibit MDA-MB-231 cell. |
Ka et al. (2021)KA, S., MERINDOL, N., SOW, A.A., SINGH, A., LANDELOUCI, K., PLOURDE, M.B., PÉPIN, G., MASI, M., DI LECCE, R., EVIDENTE, A., SECK, M., BERTHOUX, L., CHATEL-CHAIX, L. and DESGAGNÉ-PENIX, I., 2021. Amaryllidaceae alkaloid cherylline inhibits the replication of dengue and zika viruses. Antimicrobial Agents and Chemotherapy, vol. 65, no. 9, e0039821. http://dx.doi.org/10.1128/AAC.00398-21. PMid:34152811. http://dx.doi.org/10.1128/AAC.00398-21...
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Evaluate the antivirus activity of an alkaloid extract of Crinum jagus
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Crinum jagus (J.Thomps) Dandy, |
Crinum jagus alkaloid extract and cherilline presented antiviral activity against DENV, ZIKV, but were inactive against HIV-1. |
Cole et al. (2019)COLE, E.R., ANDRADE, J.P., ALLOCHIO FILHO, J.F, SCHMITT, E.F.P., ALVES-ARAÚJO, A., BASTIDA, J., ENDRINGER, D.C., BORGES, W.S. and LACERDA, V., 2019. Cytotoxic and genotoxic activities of alkaloids from the bulbs of Griffinia gardneriana and Habranthus itaobinus (Amaryllidaceae). Anti-cancer Agents in Medicinal Chemistry, vol. 19, no. 5, pp. 707-717. http://dx.doi.org/10.2174/1871520619666190118122523. PMid:30657047. http://dx.doi.org/10.2174/18715206196661...
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The cytotoxicity of alkaloids from two Amaryllidaceae species was evaluated |
Griffinia gardneriana (Herb.) Ravenna; Zephyranthes cearensis (Herb.) Baker |
11-hydroxyvittatine and 2-α-7-dimethoxyhomolycorine were not toxic to tested cell lines (L929, HepG2, MCF-7, A549). Tazzetine, trisphaeridine, and sanguinine showed activity on fibroblast lineage (L929). Lycorine and pretazettine were 10 to 30 folds more cytotoxic than the other alkaloids to all cell lines, presented genotoxicity, and promoted apoptosis via the caspase-3 pathway. |
Tegegne et al. (2022)TEGEGNE, B.A., MEKURIA, A.B. and BIRRU, E.M., 2022. Evaluation of anti-diabetic and anti-hyperlipidemic activities of hydro-alcoholic crude extract of the shoot tips of Crinum abyssinicum Hochst. ex A. Rich (Amaryllidaceae) in mice. Journal of Experimental Pharmacology, vol. 14, pp. 27-41. http://dx.doi.org/10.2147/JEP.S335650. PMid:35136357. http://dx.doi.org/10.2147/JEP.S335650...
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The anti-diabetes and anti-hyperlipidemic activities of Crinum abyssinicum extract were tested in mice |
Crinum abyssinicum Hochst. ex A. Rich |
A hydro-alcoholic extract of Crinum abyssinicum shoot tips presented anti-hyperglycemic, anti-hyperlipidemic, and body weight improvements in streptozotocin-induced diabetic mice. Moreover, it showed hypoglycaemic and anti-hyperglycaemic activities in normoglycemic and oral glucose-loaded mice, respectively, corroborating the traditional use of this plant as an antidiabetic remedy. |
Benedec et al. (2018)BENEDEC, D., ONIGA, I., HANGANU, D., GHELDIU, A.M., PUȘCAȘ, C., SILAGHI-DUMITRESCU, R., DUMA, M., TIPERCIUC, B., VÂRBAN, R. and VLASE, L., 2018. Sources for developing new medicinal products: biochemical investigations on alcoholic extracts obtained from aerial parts of some Romanian Amaryllidaceae species. BMC Complementary and Alternative Medicine, vol. 18, no. 1, pp. 226. http://dx.doi.org/10.1186/s12906-018-2292-8. PMid:30053845. http://dx.doi.org/10.1186/s12906-018-229...
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Four Amaryllidaceae species were evaluated for antioxidant and antimicrobial activities. |
Galanthus nivalis L., Narcissus pseudonarcissus L., N. poeticus L., Leucojum vernum L. |
The hydroetanolic extracts of aerial parts were tested against Salmonella typhimurium, Escherichia coli, Listeria monocytogenes, Staphylococcus aureus, Candida albicans, and Aspergillus brasiliensis. Concerning the five antioxidant assays, only G. nivalis extract showed activity. Galanthus nivalis and L. vernum inhibited S. aureus growth, and N. poeticus presented antifungal activity. |
Eriksson et al. (2012)ERIKSSON, A.H., RØNSTED, N., GÜLER, S., JÄGER, A.K., SENDRA, J.R. and BRODIN, B., 2012. In-vitro evaluation of the P-glycoprotein interactions of a series of potentially CNS-active Amaryllidaceae alkaloids. The Journal of Pharmacy and Pharmacology, vol. 64, no. 11, pp. 1667-1677. http://dx.doi.org/10.1111/j.2042-7158.2012.01536.x. PMid:23058055. http://dx.doi.org/10.1111/j.2042-7158.20...
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Amaryllidaceae alkaloids were evaluated for P-glycoprotein interaction |
Some tested alkaloids were isolated from Crinum bulbispermum (Burm.f.) Milne-Redh. & Schweik, C. moorei Hook.f., and Cyrtanthus falcatus R.A.Dyer |
Nine Amaryllidaceae alkaloids were tested on P-gp mediated calcein-AM efflux. Epibuphanisine, papyramine and lycorine did not interact with P-gp. Galanthamine showed weak interaction. Crinine, 6-hydroxycrinamine, powelline, 3-O-acetylhamayne and 1-epi-deacetylbowdenisine showed interaction with P-gp. It was observed that there was no structure-activity relationship. |
Masi et al. (2019)MASI, M., VAN SLAMBROUCK, S., GUNAWARDANA, S., VAN RENSBURG, M.J., JAMES, P.C., MOCHEL, J.G., HELISO, P.S., ALBALAWI, A.S., CIMMINO, A., VAN OTTERLO, W.A.L., KORNIENKO, A., GREEN, I.R. and EVIDENTE, A., 2019. Alkaloids isolated from Haemanthus humilis Jacq., an indigenous South African Amaryllidaceae: anticancer activity of coccinine and montanine. South African Journal of Botany, vol. 126, pp. 277-281. http://dx.doi.org/10.1016/j.sajb.2019.01.036. http://dx.doi.org/10.1016/j.sajb.2019.01...
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Alkaloids from Haemanthus humilis bulbs were tested for cytotoxicity |
Haemanthus humilis Jacq. |
Montanine inhibit the growth of all tested cell lines (A549, HCT-15, SK-MEL-28, MCF7, MDA-MB-231, Hs578T); coccinine also was active except in SK-MEL-28. Incartine and albomaculine did not present activity. |
Onishi et al. (2012)ONISHI, Y., KAWANO, Y. and YAMAZAKI, Y., 2012. Lycorine, a candidate for the control of period length in mammalian Cells. Cellular Physiology and Biochemistry, vol. 29, no. 3-4, pp. 407-416. http://dx.doi.org/10.1159/000338495. PMid:22508048. http://dx.doi.org/10.1159/000338495...
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Lycorine and lycoricidinol (narciclasine) were evaluated for possible interference in the circadian period using a real-time reporter gene assay system based on NIH3T3 cells. |
Lycoris radiata (L’Hérb.) Herb. |
Both alkaloids promoted the elongation of the circadian period in a reversible way. Authors suggested that lycorine and lycoricidinol modulate Bmal1 transcription and the circadian period, and Lycoris alkaloids can contribute to the control of period length in mammalian cells. |
Doskočil et al. (2015)DOSKOČIL, I., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., BENEŠOVÁ, N., HAVLÍK, J., HAVELEK, R., KUNEŠ, J., KRÁLOVEC, K., CHLEBEK, J. and CAHLÍKOVÁ, L., 2015. Cytotoxic activities of Amaryllidaceae alkaloids against gastrointestinal cancer cells. Phytochemistry Letters, vol. 13, pp. 394-398. http://dx.doi.org/10.1016/j.phytol.2015.08.004. http://dx.doi.org/10.1016/j.phytol.2015....
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Alkaloids from two Amaryllidaceae species were evaluated for toxicity to gastrointestinal cancer cells. |
Zephyranthes robusta (Herb. ex Sweet) Baker, Chlidanthus fragans Herb. |
Thirteen alkaloids were tested for toxicity to CaCo-2, HT-29, and FHs-74 Int cell strains.Haemanthamine, haemanthidine and lycorine presented toxicity to cancer cells and low toxicity to the normal line (FHs-74). |
Cavallaro et al. (2014)CAVALLARO, V., ALZA, N.P., MURRAY, M.G. and MURRAY, A.P., 2014. Alkaloids from Habranthus tubispathus and H. jamesonii, two amaryllidaceae with acetyl- and butyrylcholinesterase inhibition activity. Natural Product Communications, vol. 9, no. 2, pp. 159-162. http://dx.doi.org/10.1177/1934578X1400900206. PMid:24689279. http://dx.doi.org/10.1177/1934578X140090...
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Alkaloids from two Amaryllidaceae plants presenting acetyl- and butyrylcholinesterase-inhibiting activity |
Zephyranthes tubispatha (L’Hérb) Herb., Habranthus jamesonii (Baker) Ravenna |
The levels of lycorine and hypeastidine, important AChE inhibitors, observed in H. tubispathus bulbs may be responsible for AChE inhibition. |
Cortes et al. (2015)CORTES, N., POSADA-DUQUE, R.A., ALVAREZ, R., ALZATE, F., BERKOV, S., CARDONA-GÓMEZ, G.P. and OSORIO, E., 2015. Neuroprotective activity and acetylcholinesterase inhibition of five Amaryllidaceae species: a comparative study. Life Sciences, vol. 122, pp. 42-50. http://dx.doi.org/10.1016/j.lfs.2014.12.011. PMid:25529145. http://dx.doi.org/10.1016/j.lfs.2014.12....
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Alkaloid-rich fractions from five Amaryllidaceae species were tested for neuroprotective activity in an ex-vivo model (glutamate excitotoxicity in rat cortical neurons) |
Urceolina bonplandii (Kunth) Traub, U. caucana (Meerow) Christenh. & Byng, Clivia miniata Regel, Crinum jagus (J.Thomps) Dandy, Phaedranassa lehmannii Regel, Hippeastrum elegans (Spreng.) H.E. Moore |
Alkaloid-rich fractions from U. bonplandii bulbs, U. caucana bulbs, and C. miniata leaves, exerted neuroprotective action. Authors, suggested the activity is due to the ability to stabilize the free radicals generated from an excitotoxic process mediated by Glutamate. |
Sóto-Vasquez et al. (2022) |
Alkaloid-rich fraction was tested for AChE and BUChE inhibition and antiplasmodial against Plasmodium falciparum activity in vitro
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Ismene amancaes Herb. |
The alkaloid-rich fraction of I. amancaes bulbs presented low AChE and BuChE and moderate antiplasmodial activities |
Sóto-Vasquez et al. (2021) |
Alkaloid-rich fractions of two Clinanthus species were tested in vitro for antiplasmodial activity against Plasmodium falciparum
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Clinanthus incarnatus (Kunth) Meerow, C. ruber (Herb.) Meerow & A.Cano |
The alkaloid-rich fractions presented activity against P. falciparum Chloroquine-resistant strain |
Kaya et al. (2017)KAYA, G.I., UZUN, K., BOZKURT, B., ONUR, M.A., SOMER, N.U., GLATZEL, D.K. and FÜRST, R., 2017. Chemical characterization and biological activity of an endemic Amaryllidaceae species: galanthus cilicicus. South African Journal of Botany, vol. 108, pp. 256-260. http://dx.doi.org/10.1016/j.sajb.2016.11.008. http://dx.doi.org/10.1016/j.sajb.2016.11...
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In vitro evaluation of AChE and BuChE inhibition and anti-inflammatory activity |
Galanthus cilicicus Baker |
The alkaloid-rich fraction from aerial parts and bulbs of G.cilicicus did not affect the viability of HUVEC cells. Both fractions inhibited AChE and BuChE and presented potential anti-inflammatory activity by inhibiting the interaction of leukocytes and endothelial cells |
Karakaya et al. (2019)KARAKAYA, S., EKSI, G., KOCA, M., DEMIRCI, B., KAYMAK, H.C., KAPLAN, M.E. and AKSAKAL, O., 2019. Chemical and morphological characterization of Allium tuncelianum (Amaryllidaceae) and its antioxidant and anticholinesterase potentials. Anales del Jardin Botanico de Madrid, vol. 76, no. 2, e085. http://dx.doi.org/10.3989/ajbm.2523. http://dx.doi.org/10.3989/ajbm.2523...
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Anti-oxidant and AChE and BUChE inhibition of extract, fractions and essential oil of Allium tuncelianum
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Allium tuncelianum (Kollmann) Özhatay, B.Mathew & Siraneci |
All samples inhibited AChE and BuChE and the ethyl acetate fraction was the most active. |
Castillo et al. (2018)CASTILLO, W.O., ARISTIZABAL-PACHON, A.F., SAKAMOTO-HOJO, E., GASCA, C.A., CABEZAS-FAJARDO, F.A. and TAKAHASHI, C., 2018. Caliphruria subedentata (Amaryllidaceae) decreases genotoxicity and cell death induced by β-amyloid peptide in SH-SY5Y cell line. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol. 836, no. Pt B, pp. 54-61. http://dx.doi.org/10.1016/j.mrgentox.2018.06.010. PMid:30442346. http://dx.doi.org/10.1016/j.mrgentox.201...
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Evaluation of neuroprotetive activity against β−amyloid DNA damage |
Caliphruria subedentata Baker |
Ethanolic extract of C. subdentata aerial parts protected SH-SY5Y cells against damage by Aβ(1-42), and reduced the induced mitocondrial morphological changes and cell death. Also, protected SH-SY5Y cells against getonoxic effects and DNA strand breaks induced by Aβ(1-42). Moreover, the extract was not toxic to SH-SY5Y cells and could inhibit AChE. |
Chen et al. (2016)CHEN, G.-L., TIAN, Y.Q., WU, J.L., LI, N. and GUO, M.Q., 2016. Antiproliferative activities of Amaryllidaceae alkaloids from Lycoris radiata targeting DNA topoisomerase I. Scientific Reports, vol. 6, no. 1, pp. 38284. http://dx.doi.org/10.1038/srep38284. PMid:27922057. http://dx.doi.org/10.1038/srep38284...
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Evaluate the potential Topoisomerase I inhibition |
Lycoris radiata (L'Hér.) Herb. |
An alkaloid-rich fraction of bulbs was able to inhibit topoisomerase I in a dose-dependent way, and hippeastrine seems to be involved in the inhibition. Hippeastrine inhibited the proliferation of HT029 and HepG2 cells. |
Napo et al. (2020)NAPO, K.V., MOKOENA, L.E., MANGOEJANE, C., MFENGWANA, H., MASHELE, S. and SEKHOACHA, M.P., 2020. In vitro antiproliferative activity of Amaryllidaceae species against the K562 human leukaemia cell line. South African Journal of Botany, vol. 135, pp. 429-436. http://dx.doi.org/10.1016/j.sajb.2020.07.012. http://dx.doi.org/10.1016/j.sajb.2020.07...
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Evaluate three Amaryllidaceae species for citotoxicity to K562 leukaemia cells |
Crinum bulbispermum (Burm.f.) Milne-Redh. & Schweik., Boophone disticha Herb., Amaryllis belladona L. |
Aqueous and methanol extracts from bulbs of C. bulbispermum and B. disticha and methanol extract from A. belladona roots showed a high inhibition rate of K562 cells. |
Kianfé et al. (2020)KIANFÉ, B.Y., KÜHLBORN, J., TCHUENGUEM, R.T., TCHEGNITEGNI, B.T., PONOU, B.K., GROß, J., TEPONNO, R.B., DZOYEM, J.P., OPATZ, T. and TAPONDJOU, L.A., 2020. Antimicrobial secondary metabolites from the medicinal plant Crinum glaucum A. Chev. (Amaryllidaceae). South African Journal of Botany, vol. 133, pp. 161-166. http://dx.doi.org/10.1016/j.sajb.2020.07.026. http://dx.doi.org/10.1016/j.sajb.2020.07...
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Anti-microbial activity of extract, fractions and alkaloids from Crinum glaucum leaves |
Crinum glaucum A.Chev. |
The ethanol extract, the fractions EtOAC and n-BuOH, and 5,6-dihydrobicolorine, lycorine, and ungeremine presented mild antimicrobial activity against Enterococcus faecalis and Pseudomonas aeruginosa, Proteus mirabilis. None was active against Escherichia coli or Staphylococcus aureus
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Minkah and Danquah (2021)MINKAH, P.A.B. and DANQUAH, C.A., 2021. Anti-infective, anti-inflammatory and antipyretic activities of the bulb extracts of Crinum jagus (J. Thomps.) Dandy (Amaryllidaceae). Sci Afr., vol. 12, e00723. http://dx.doi.org/10.1016/j.sciaf.2021.e00723. http://dx.doi.org/10.1016/j.sciaf.2021.e...
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Evaluate the in vitro antimicrobial and in vivo anti-inflammatory activities of Crinum jagus
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Crinum jagus (J.Thomps) Dandy |
In rats, he bulbs’ aqueous extract presented anti-inflammatory activity and the ethanol extract showed antipyretic activity. The methanol extract inhibited the growth of Mycobacterium smegmatis, Salmonella typhi and Pseudomonas aeruginosa.
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Sikder et al. (2021)SIKDER, L., ALIM, M.I., SAIEDA, B., ISLAM, M.T., MARTORELL, M., SHARIFI-RAD, J. and KHAN, S.A., 2021. Pharmacological Activities of Crinum viviparum: A Laboratory-based Study. Journal of Herbs, Spices & Medicinal Plants, vol. 27, no. 2, pp. 177-187. http://dx.doi.org/10.1080/10496475.2021.1891177. http://dx.doi.org/10.1080/10496475.2021....
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Evaluation of the anti-bacterial, anti-inflammatory, thrombolytic, and anti-diarrheal activities |
Crinum viviparum (Lam.) R.Ansari & V.J.Nair |
The ethanolic extract of C. viviparum whole plant a very low activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Salmonella enterica. The extract presented a mild thrombolitic and anti-inflammatory activity in vitro. On the other hand, the extract presented antidiarrhoeal activity in mice. |
He et al. (2013)HE, J., QI, W.B., WANG, L., TIAN, J., JIAO, P.R., LIU, G.Q., YE, W.C. and LIAO, M., 2013. Amaryllidaceae alkaloids inhibit nuclear-to-cytoplasmic export of ribonucleoprotein (RNP) complex of highly pathogenic avian influenza virus H5N1. Influenza and Other Respiratory Viruses, vol. 7, no. 6, pp. 922-931. http://dx.doi.org/10.1111/irv.12035. PMid:23136954. http://dx.doi.org/10.1111/irv.12035...
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In vitro evaluation of 15 alkaloids against influenza A virus |
Lycoris radiata (L'Hér.) Herb. |
Lycorine, hippeastrine, hemanthamine, and 11-hydroxyvittatine presented post-treatment antiviral activity against H5N1, by blocking vRNP nuclear export. The compounds were not toxic to MDCK cells. |
Donald et al. (2018)DONALD, K.K.B., ETIENNE, E., LANDRY, K., CYRIL, D. and FELIX, Y., 2018. Evaluation of the analgesic activity of the aqueous and hydroethanolic extract from Crinum scillifolium bulbs (Amaryllidaceae). International Journal of Biochemistry Research & Review, vol. 20, no. 4, pp. 1-7. http://dx.doi.org/10.9734/IJBCRR/2017/39418. http://dx.doi.org/10.9734/IJBCRR/2017/39...
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Evaluation of the central and peripheral analgesic activity of aqueous and hydroalcoholic extracts from Crinum scillifolium bulbs in mice |
Crinum scillifolium A.Chev. |
The hydroethanolic extract exerted a dose-dependent reduction in writhes, comparable to aspirin. The aqueous extract decreased abdominal writhing induced by the acetic acid. On the other hand, the evaluation results of central analgesic activity were inconclusive. |
Omoruyi et al. (2021a)OMORUYI, S.I., DELPORT, J., KANGWA, T.S., IBRAKAW, A.S., CUPIDO, C.N., EKPO, O.E. and HUSSEIN, A.A., 2021a. In vitro neuroprotective potential of Clivia miniata and Nerine humilis (Amaryllidaceae) in MPP+-induced neuronal toxicity in SH-SY5Y neuroblastoma cells. South African Journal of Botany, vol. 136, pp. 110-117. http://dx.doi.org/10.1016/j.sajb.2020.06.028. http://dx.doi.org/10.1016/j.sajb.2020.06...
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Evaluation of the two Amaryllidaceae species neuroprotective effect in an in vitro model |
Clivia miniata (Lindl.) Bosse, Nerine humilis Herb. |
The pre-treatment of SH-SY5Y with methanol extract of C. miniata or N.humilis bulbs improved cell viability and morphology by inhibiting the toxicity and apoptosis induced by MPP+. On the other hand, the extracts showed weak antioxidant activity. |
Rahman et al. (2013)RAHMAN, M.A., HOSSAIN, S.M.A., AHMED, N.U. and ISLAM, M.S., 2013. Analgesic and anti-inflammatory effects of Crinum asiaticum leaf alcoholic extract in animal models. African Journal of Biotechnology, vol. 12, no. 2, pp. 212-218. http://dx.doi.org/10.5897/AJB12.1431. http://dx.doi.org/10.5897/AJB12.1431...
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Evaluation of analgesig and anti-inflammatory activi of Crinum asiaticum ethanol extract. |
Crinum asiaticum L. |
The ethanol extract of C. asiaticum leaves exerted anti-inflamatory and analgesic effect in mice.In analgesic assay, the extract reduced the pain induced by acetic acid; in carrageenan-induced paw edema, the extract reduced the edema. In the acute toxicity test, no death was observed among the tested animals |
Ncube et al. (2015)NCUBE, B., NAIR, J.J., RÁROVÁ, L., STRNAD, M., FINNIE, J.F. and VAN STADEN, J., 2015. Seasonal pharmacological properties and alkaloid content in Cyrtanthus contractus NE Br. South African Journal of Botany, vol. 97, pp. 69-76. http://dx.doi.org/10.1016/j.sajb.2014.12.005. http://dx.doi.org/10.1016/j.sajb.2014.12...
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Sazonal influence on biological activity and alkaloid content |
Cyrtanthus contractus NE Br. |
High alkaloid amounts were observed in high temperature and rainfall period. The cytotoxicity of the ethanol extract of bulbs to CEM, MCF7, HeLa and BJ cell lines varied, depending on the period of the bulbs collection. The extract also was able to inhibit COX-1 and -2, as well as AChE and presented antimicrobial activity against Bacillus subtilis, Klebsiela pneumoniae, Staphulococcus aureus and Escherichia coli, comparable to Neomycin; and anticandida activity comparable to Amphotericin B |
Tallini et al. (2021a)TALLINI, L.R., CARRASCO, A., ACOSTA LEÓN, K., VINUEZA, D., BASTIDA, J. and OLEAS, N.H., 2021a. Alkaloid profiling and cholinesterase inhibitory potential of Crinum × amabile Donn. (Amaryllidaceae) collected in Ecuador. Plants, vol. 10, no. 12, pp. 2686. http://dx.doi.org/10.3390/plants10122686. PMid:34961157. http://dx.doi.org/10.3390/plants10122686...
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Alkaloid profile and enzyme inhibition by ethanol extracts from bulbs and leaves of Crinum x amabile
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Crinum x amabile Donn.
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Ethanol extracts from bulbs and leaves inhibited AChE and BuChE in an in vitro model. |
Silva et al.(2022)SILVA, L.C., CORREIA, A.F., GOMES, J.V.D., ROMÃO, W., MOTTA, L.C., FAGG, C.W., MAGALHÃES, P.O., SILVEIRA, D. and FONSECA-BAZZO, Y.M., 2022. Lycorine Alkaloid and Crinum americanum L. (Amaryllidaceae) extracts display antifungal activity on clinically relevant Candida species. Molecules, vol. 27, no. 9, pp. 2976. http://dx.doi.org/10.3390/molecules27092976. PMid:35566325. http://dx.doi.org/10.3390/molecules27092...
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Lycorine and ethanol extracts from bulbs and leaves of Crinum americanum with anticandida effects |
Crinum americanum L |
Ethanol extracts from bulbs and leaves of C. americanum presented moderate activity against Candida auris, C. albicans, C. krusei and C. parapsilosis. |
Isbilen et al. (2018)ISBILEN, O., RIZANER, N. and VOLKAN, E., 2018. Anti-proliferative and cytotoxic activities of Allium autumnale PH Davis (Amaryllidaceae) on human breast cancer cell lines MCF-7 and MDA-MB-231. BMC Complementary and Alternative Medicine, vol. 18, no. 1, pp. 30. http://dx.doi.org/10.1186/s12906-018-2105-0. PMid:29370794. http://dx.doi.org/10.1186/s12906-018-210...
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Allium autumnale bulbs and stem presented low in vitro cytotoxic activity |
Allium autumnale P.H.Davis |
The ethanol extracts of bulbs and stems were not toxic to MCF-7 and MDA-MB-231 cells. |
Attia et al. (2021)ATTIA, E.Z., KHALIFA, M.F., FAHIM, J.R. and KAMEL, M.S., 2021. Anti-diabetic potential of mucilage from Hippeastrum vittatum bulbs in streptozotocin-induced diabetic rats. South African Journal of Botany, vol. 136, pp. 100-104. http://dx.doi.org/10.1016/j.sajb.2020.06.027. http://dx.doi.org/10.1016/j.sajb.2020.06...
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Mucilage isolated from Hippeastrum vittatum bulbs presented hypoglycaemic activity in rats |
Hippeastrum vittatum (L'Hér.) Herb |
Oral administration of the mucilage ameliorated the induced hyperglycaemia in rats |
El Samarji et al. (2023)EL SAMARJI, M., YOUNES, M., EL KHOURY, M., HAYKAL, T., ELIAS, N., GASILOVA, N., MENIN, L., HOURI, A., MACHAKA-HOURI, N. and RIZK, S., 2023. Effects of Sternbergia clusiana bulb ethanolic extract on Triple-Negative and Estrogen-Dependent breast cancer cells in vitro. Plants, vol. 12, no. 3, pp. 529. http://dx.doi.org/10.3390/plants12030529. PMid:36771614. http://dx.doi.org/10.3390/plants12030529...
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Evaluate the in vitro anti-proliferative effect of ethanol extract from Sternbergia clusiana bulbs. |
Sternbergia clusiana Ker Gawl. ex Schult. |
The extract reduced the viability of MCF-7 and MDA-MB-231 cells, with no effect on normal mesenchymal stem cells. The effect seems to be throught the activation of the apoptotic pathway due to the increase in cellular and DNA fragmentation; alterations in apoptotic proteins (Bax, Bcl-2 and c-PARP);and a decrease in ROS production. |
Gomes-Copeland et al. (2022)GOMES-COPELAND, K.K.P., MEIRELES, C.G., GOMES, J.V.D., TORRES, A.G., SINOTI, S.B.P., FONSECA-BAZZO, Y.M., MAGALHÃES, P.O., FAGG, C.W., SIMEONI, L.A. and SILVEIRA, D., 2022. Hippeastrum stapfianum (Kraenzl.) R.S.Oliveira & Dutilh (Amaryllidaceae) ethanol extract activity on acetylcholinesterase and PPAR-α/γ Receptors. Plants, vol. 11, no. 22, pp. 3179. http://dx.doi.org/10.3390/plants11223179. PMid:36432907. http://dx.doi.org/10.3390/plants11223179...
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Evaluation of ethanol extract from H. stapfianum leaves on AChE activity nuclear receptors PPAR-α and PPAR-γ. |
Hippeastrum stapfianum (Kraenzl.) R.S.Oliveira & Dutilh |
The ethanol extract of H. stapfianum activated PPAR-α and PPAR-γ, presented mild AChE inhibition and antioxidant activity |
Taiwe et al. (2016)TAIWE, G.S., TCHOYA, T.B., MENANGA, J.R., DABOLE, B. and DE WAARD, M., 2016. Anticonvulsant activity of an active fraction extracted from Crinum jagus L.(Amaryllidaceae), and its possible effects on fully kindled seizures, depression-like behaviour and oxidative stress in experimental rodent models. Journal of Ethnopharmacology, vol. 194, pp. 421-433. http://dx.doi.org/10.1016/j.jep.2016.10.023. PMid:27725241. http://dx.doi.org/10.1016/j.jep.2016.10....
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Evaluation of anticonvulsivant activity of Crinum jagus
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Crinum jagus (J.Thomps) Dandy |
A flavonoid-rich fraction of an ethyl acetate extract of leaves increased the latency to myoclonic jerks, clonic seizures, and decreased the number of myoclonic jerks in PTZ-kindled mice. Moreover, the fraction did not alter the locomotion of animals in the open-field or rotarod tests, and decreased lipid peroxidation, and augmented endogenous antioxidant enzymes in brain. |
Donald et al. (2017a)DONALD, K.K.B., MARINA, N.T.A.D., TIMOTHÉE, O.A., LANDRY, K.S. and FELIX, Y.H., 2017a. Evaluation of the anticonvulsant activity of the aqueous extract of Crinum scillifolium bulbs (Amaryllidaceae) in experimental animals. IOSR Journal of Pharmacy and Biological Sciences, vol. 12, no. 3, pp. 35-39. http://dx.doi.org/10.9790/3008-1203043539. http://dx.doi.org/10.9790/3008-120304353...
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Evaluation of anticonvulsivant activity of Crinum scillifolium
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Crinum scillifolium A.Chev. |
The aqueous extract of Crinum scillifolium bulbs protected mice against seizures induced by isoniazid, increased seizure latency, and reduced the occurrence of death. |
Donald et al. (2017b)DONALD, K.K.B., LANDRY, K.S., FRANCIS, Y.A., FELIX, Y.H., MARINA, N.A.D., PATRICE, M.B.A. and SIRANSY, K.G., 2017b. Evaluation of the anticonvulsant activity of the hydroethanolic extract of Crinum scillifolium bulbs (Amaryllidaceae) in experimental animals. Adv Pharmacol Pharm, vol. 5, no. 2, pp. 25-30. http://dx.doi.org/10.13189/app.2017.050202. http://dx.doi.org/10.13189/app.2017.0502...
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Evaluation of anticonvulsivant activity of Crinum scillifolium
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Crinum scillifolium A.Chev. |
The hydroethanolic extract of Crinum scillifolium bulbs protected mice against seizures induced by isoniazid, delayed the convulsion onset, and no mortality was found of the mice against isoniazid-induced convulsion. |
Gonring-Salarini et al. (2019)GONRING-SALARINI, K.L., CONTI, R., DE ANDRADE, J.P., BORGES, B.J., AGUIAR, A.C., DE SOUZA, J., ZANINI, C., OLIVA, G., TENORIO, J.C., ELLENA, J., BASTIDA, J., GUIDO, R. and BORGES, W., 2019. In vitro antiplasmodial activities of alkaloids isolated from roots of Worsleya procera (Lem.) Traub (Amaryllidaceae). Journal of the Brazilian Chemical Society, vol. 30, pp. 1624-1633. http://dx.doi.org/10.21577/0103-5053.20190061. http://dx.doi.org/10.21577/0103-5053.201...
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Evaluation of antiplasmodial activity of Worsleya procera roots |
Worsleya procera (Lem.) Traub |
Fractions of methanol extract from W. procera roots presented antiplasmodial activity. The fractions presented low toxicity to HepG2 cells. Among isolated alkaloids, only lycorine presented activity against Plasmodium falciparum 3D7 and K1 strains without reducing the HepG2 cell viability. |
Johnson et al. (2018)JOHNSON, M., MAHARAJA, P., JANAKIRAMAN, N., ADAIKALA RAJ, G., MENEZES, I.R.A., DA COSTA, J.G.M., VERDE, L.C.L. and COUTINHO, H.D.M., 2018. Pancratium triflorum Roxb.(Amaryllidaceae) and Molineria trichocarpa (Wight) NP Balakr (Hypoxidaceae): cytotoxic and antioxidant activities. Food and Chemical Toxicology, vol. 119, pp. 290-295. http://dx.doi.org/10.1016/j.fct.2018.02.055. PMid:29596974. http://dx.doi.org/10.1016/j.fct.2018.02....
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Evaluation of cytotoxicity and antioxidant activity of Pancratium triflorum whole plant extracts |
Pancratium triflorum Roxb. |
The petroleum ether, acetone, chloroform, and methanol extracts from P.triflorum whole plant were tested for antioxidant potential and were not active. All extracts presented moderate toxicity to Artemia salina larvae. |
Nasir et al. (2022)NASIR, S., WALTERS, K.F.A., PEREIRA, R.M., WARIS, M., ALI CHATHA, A., HAYAT, M. and BATOOL, M., 2022. Larvicidal activity of acetone extract and green synthesized silver nanoparticles from Allium sativum L.(Amaryllidaceae) against the dengue vector Aedes aegypti L.(Diptera: culicidae). Journal of Asia-Pacific Entomology, vol. 25, no. 3, pp. 101937. http://dx.doi.org/10.1016/j.aspen.2022.101937. http://dx.doi.org/10.1016/j.aspen.2022.1...
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Silver nanoparticules of Allium sativum were active against Aedes aegypti |
Allium sativum L. |
Silver nanoparticules containing acetone extract of A. sativum bulbs presented larvicidal activity against Aedes aegypti 2nd and 3rd instar larvae |
Martinez-Peinado et al. (2022)MARTINEZ-PEINADO, N., ORTIZ, J.E., CORTES-SERRA, N., PINAZO, M.J., GASCON, J., TAPIA, A., ROITMAN, G., BASTIDA, J., FERESIN, G.E. and ALONSO-PADILLA, J., 2022. Anti-Trypanosoma cruzi activity of alkaloids isolated from Habranthus brachyandrus (Amaryllidaceae) from Argentina. Phytomedicine, vol. 101, pp. 154126. http://dx.doi.org/10.1016/j.phymed.2022.154126. PMid:35489322. http://dx.doi.org/10.1016/j.phymed.2022....
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Anti-Trypanosoma cruzi activity of alkaloids isolated from Zephyrantes brachyandra
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Zephyranthes brachyandra (Baker) Baker |
The extract showed specific anti-T. cruzi activity; ismine seems to be partially responsible for this. These results encourage the exploration of Z. brachyandra alkaloids in search of new starting points for developing drugs for Chagas disease. |
Gasca et al. (2020)GASCA, C.A., MOREIRA, N.C.S., DE ALMEIDA, F.C., DUTRA GOMES, J.V., CASTILLO, W.O., FAGG, C.W., MAGALHÃES, P.O., FONSECA-BAZZO, Y.M., SAKAMOTO-HOJO, E., DE MEDEIROS, Y.K., DE SOUZA BORGES, W. and SILVEIRA, D., 2020. Acetylcholinesterase inhibitory activity, anti-inflammatory, and neuroprotective potential of Hippeastrum psittacinum (Ker Gawl.) herb (Amaryllidaceae). Food and Chemical Toxicology, vol. 145, pp. 111703. http://dx.doi.org/10.1016/j.fct.2020.111703. PMid:32858133. http://dx.doi.org/10.1016/j.fct.2020.111...
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Acetylcholinesterase inhibitory activity, anti-inflammatory, and neuroprotective potential of Hippeastrum psittacinum
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Hippeastrum psittacinum Herb. |
Ethanol extract and alkaloid fractions from H. psittacinum bulbs inhibited AChE. H. psittacinum protected SH-SY5Y cells from hydrogen peroxide-induced neurotoxicity. |
Hulcova et al. (2019) |
Amaryllidaceae alkaloids from Narcissus pseudonarcissus as potential drugs in the treatment of Alzheimer's disease |
Narcissus pseudonarcissus L. cv. Dutch Master |
Narcimatulin revealed an interesting multipotent profile exerting inhibition properties for BuChE and AChE enzymes. |
Al Mamun et al. (2020)AL MAMUN, A., MAŘÍKOVÁ, J., HULCOVÁ, D., JANOUŠEK, J., ŠAFRATOVÁ, M., NOVÁKOVÁ, L., KUČERA, T., HRABINOVÁ, M., KUNEŠ, J., KORÁBEČNÝ, J. and CAHLÍKOVÁ, L., 2020. Amaryllidaceae alkaloids of belladine-type from Narcissus pseudonarcissus cv. Carlton as new selective inhibitors of butyrylcholinesterase. Biomolecules, vol. 10, no. 5, pp. 800. http://dx.doi.org/10.3390/biom10050800. PMid:32455879. http://dx.doi.org/10.3390/biom10050800...
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Amaryllidaceae alkaloids of the belladine type of Narcissus pseudonarcissus as new selective butyrylcholinesterase inhibitors |
Narcissus pseudonarcissus cv. Carlton |
Carltonine showed important direct inhibitory action on BuChE and AChE. |
Katoch and Sharma (2019)KATOCH, D. and SHARMA, U., 2019. Simultaneous quantification and identification of Amaryllidaceae alkaloids in Narcissus tazetta by ultra performance liquid chromatography-diode array detector-electrospray ionisation tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, vol. 175, pp. 112750. http://dx.doi.org/10.1016/j.jpba.2019.06.047. PMid:31330284. http://dx.doi.org/10.1016/j.jpba.2019.06...
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Simultaneous quantification and identification of Amaryllidaceae Alkaloids in Narcissus tazetta by ultra performance liquid chromatography, diode array detector-electrospray ionization tandem mass spectrometry. |
Narcissus tazetta L. |
Leaves and flowers are good sources of alkaloids in addition to bulbs. They can be used to inhibit enzymes capable of causing neurodegenerative diseases. |
Al Shammari et al. (2021)AL SHAMMARI, L., HULCOVÁ, D., MAŘÍKOVÁ, J., KUČERA, T., ŠAFRATOVÁ, M., NOVÁKOVÁ, L., SCHMIDT, M., PULKRÁBKOVÁ, L., JANOUŠEK, J., SOUKUP, O., KUNEŠ, J., OPLETAL, L. and CAHLÍKOVÁ, L., 2021. Amaryllidaceae alkaloids from Hippeastrum X Hybridum CV. Ferrari, and preparation of vittatine derivatives as potential ligands for Alzheimer’s disease. South African Journal of Botany, vol. 136, pp. 137-146. http://dx.doi.org/10.1016/j.sajb.2020.06.024. http://dx.doi.org/10.1016/j.sajb.2020.06...
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Amaryllidaceae alkaloids from Hippeastrum X hybridum, and preparation of vittatine derivatives as potential ligands for Alzheimer’s disease |
Hippeastrum X hybridum CV. Ferrari |
Potential treatment for Alzheimer’s disease confirmed, and expectations for developing new pharmaceutical products. |
Kohelova et al. (2021) |
Alkaloids from Zephyranthes citrina and their implication in Alzheimer’s disease: isolation, structural elucidation and biological activity |
Zephyranthes citrina Baker |
A significant ability to inhibit human AChE and BuChE was detected. This property was demonstrated by alkaloid narcyyline. This compound is also predicted to cross the blood-brain barrier (BBB) through passive diffusion. |
Maříková et al. (2021)MAŘÍKOVÁ, J., MAMUN, A.A., SHAMMARI, L.A., KORÁBEČNÝ, J., KUČERA, T., HULCOVÁ, D., KUNEŠ, J., MALANÍK, M., VAŠKOVÁ, M., KOHELOVÁ, E., NOVÁKOVÁ, L., CAHLÍKOVÁ, L. and POUR, M., 2021. Structure elucidation and cholinesterase inhibition activity of two new minor Amaryllidaceae alkaloids. Molecules, vol. 26, no. 5, pp. 1279. http://dx.doi.org/10.3390/molecules26051279. PMid:33652925. http://dx.doi.org/10.3390/molecules26051...
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Elucidation of the structure and cholinesterase inhibition activity of two new minor alkaloids from Amaryllidaceae |
Hippeastrum hybridum, Narcisus pseudonarcissus
|
Narcikachnine-type alkaloids possess an interesting structural framework with the potential for cholinesterase inhibition and the production of a new herbal medicine. |
Salas Olivet et al. (2020)SALAS OLIVET, E., SÁNCHEZ-MILÁN, D.C., CUÉLLAR CUÉLLAR, A., MANGAS MARÍN, R., ARENCIBIA, J.A. and GARCÍA-BELTRÁN, J.A., 2020 [viewed 16 July 2023]. Estudio farmacognóstico de Hymenocallis caribaea (Amaryllidaceae). Revista del Jardín Botánico Nacional [online], vol. 41, pp. 109-117. Available from: https://www.jstor.org/stable/26975233 https://www.jstor.org/stable/26975233...
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Pharmacognostic study of Hymenocallis caribaea
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Hymenocallis caribaea L (Herb) |
Suggests the presence of phenols, flavonoids, saponins, and especially alkaloids. |
Rojas-Vera et al. (2021)ROJAS-VERA, J.D.C., BUITRAGO-DÍAZ, A.A., POSSAMAI, L.M., TIMMERS, L.F.S.M., TALLINI, L.R. and BASTIDA, J., 2021. Alkaloid profile and cholinesterase inhibition activity of five species of Amaryllidaceae family collected from Mérida state-Venezuela. South African Journal of Botany, vol. 136, pp. 126-136. http://dx.doi.org/10.1016/j.sajb.2020.03.001. http://dx.doi.org/10.1016/j.sajb.2020.03...
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Alkaloid profile and cholinesterase inhibition activity of five Amaryllidaceae species collected in Mérida,Venezuela |
Crinum amabile Donn ex Ker Gawl., C. americanum L., C. moorei Hook.f., Amaryllis belladonna L, Zephyranthes carinata Herb. |
Alkaloid extracts showed a high to a moderate inhibitory effect on AChE and BuChE. The alkaloid bufanisine demonstrated interesting theoretical inhibitory activity against BuChE by molecular docking. |
Zaragoza-Puchol et al. (2021)ZARAGOZA-PUCHOL, D., ORTIZ, J.E., ORDEN, A.A., SANCHEZ, M., PALERMO, J., TAPIA, A., BASTIDA, J. and FERESIN, G.E., 2021. Alkaloids analysis of Habranthus cardenasianus (Amaryllidaceae), anti-cholinesterase activity and biomass production by propagation strategies. Molecules, vol. 26, no. 1, pp. 192. http://dx.doi.org/10.3390/molecules26010192. PMid:33401696. http://dx.doi.org/10.3390/molecules26010...
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Analysis of Habranthus cardenasianus alkaloids, anti-cholinesterase activity, and biomass production by propagation strategies |
Habranthus cardenasianus Traub. & I.S.Nelson |
The alkaloid analysis of bulbs showed that they are a source of antitumor alkaloids, especially pretazettin (tazettin), and a sustainable strategy for their propagation and domestication for bioactive alkaloid production. |
Seoposengwe et al. (2013)SEOPOSENGWE, K., VAN TONDER, J.J. and STEENKAMP, V., 2013. In vitro neuroprotective potential of four medicinal plants against rotenone-induced toxicity in SH-SY5Y neuroblastoma cells. BMC Complementary and Alternative Medicine, vol. 13, no. 1, pp. 353. http://dx.doi.org/10.1186/1472-6882-13-353. PMid:24330357. http://dx.doi.org/10.1186/1472-6882-13-3...
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In vitro neuroprotective potential of medicinal plants against rotenone-induced toxicity in SH-SY5Y neuroblastoma cells |
Crinum bulbispermum (Burm.f.) Milne-Redh. & Schweik. |
Plant bulb extracts at concentrations as high as 25 μg/mL offered little protection to SH-SY5Y cells pre-exposed to the harmful effects of isoflavone rotenone, being potentially toxic. |
Voss and Kuriakose (2014)VOSS, C.D. and KURIAKOSE, B.B., 2014. Pharmacognostic and phytochemical evaluation of the bulbs of Hippeastrum puniceum (Lam.). International Journal of Pharmacognosy and Phytochemical Research, vol. 6, pp. 399-404.
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Pharmacognostic and phytochemical evaluation of the bulbs of Hippeastrum puniceum
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Hippeastrum puniceum (Lam.) Kuntze |
The plant has the potential ability to treat inflammatory diseases, gastrointestinal disorders and cancer. |
Adewusi et al. (2012)ADEWUSI, E.A., FOUCHE, G. and STEENKAMP, V., 2012. Cytotoxicity and acetylcholinesterase inhibitory activity of an isolated crinine alkaloid from Boophane disticha (Amaryllidaceae). Journal of Ethnopharmacology, vol. 143, no. 2, pp. 572-578. http://dx.doi.org/10.1016/j.jep.2012.07.011. PMid:22835813. http://dx.doi.org/10.1016/j.jep.2012.07....
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Cytotoxicity and acetylcholinesterase inhibitory activity of a crinine alkaloid isolated from Boophone disticha
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Boophone disticha Herb. |
The compound 6-hidroxycrinamine was found to be toxic to neuroblastoma cells. Despite the toxicity of crinine-type alkaloids, quantitative studies of the structure-activity relationship can be used to modify the structures to make them less harmful and improve their activity. |
Le et al. (2023)LE, N.T.H., DE JONGHE, S., ERVEN, K., VERMEYEN, T., BALDÉ, A.M., HERREBOUT, W.A., NEYTS, J., PANNECOUQUE, C., PIETERS, L. and TUENTER, E., 2023. Anti-SARS-CoV-2 activity and cytotoxicity of amaryllidaceae alkaloids from Hymenocallis littoralis. Molecules, vol. 28, no. 7, pp. 3222. http://dx.doi.org/10.3390/molecules28073222. PMid:37049986. http://dx.doi.org/10.3390/molecules28073...
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Anti-SARS-CoV-2 Activity and cytotoxicity of Amaryllidaceae Alkaloids from Hymenocallis littoralis
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Hymenocallis littoralis (Jacq.) Salisb. |
Assessment of cytotoxicity on the Vero-E6 cell line revealed lycorine and pancratistatin as cytotoxic substances with CC50 values of 1.2 µM and 0.13 µM, respectively. The preliminary structure-activity relationship for the lycorine-type alkaloids in this study was further investigated, and as a result, ring C appears to play a crucial role in their anti-SARS-CoV-2 activity. |
Butler and Johnson (2022)BUTLER, H.C. and JOHNSON, S.D., 2022. Seed dispersal by monkey spitting in Scadoxus (Amaryllidaceae): fruit selection, dispersal distances and effects on seed germination. Austral Ecology, vol. 47, no. 5, pp. 1029-1036. http://dx.doi.org/10.1111/aec.13193. http://dx.doi.org/10.1111/aec.13193...
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Seed dispersal by monkey spittoon in Scadoxus (Amaryllidaceae): fruit selection, dispersal distances, and effects on seed germination |
Scadoxus multiflorus (Martyn) Raf., S. puniceus L. Friis & Nordal |
Seeds of Scadoxus are unorthodox, supposedly poisonous, and encased in fleshy fruits. The ripe red fruits of Scadoxus attract monkeys, who consume the fleshy fruit and spit out the seeds, putting the community at risk. |