Xylaria sp.
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Xylocetal-Band and derivatives |
Reduction of ROS synthesis |
Zebrafish and PC12 cells |
Li et al., 2013LI, S., SHEN, C., GUO, W., ZHANG, X., LIU, S., LIANG, F., XU, Z., PEI, Z., SONG, H., QIU, L., LIN, Y. and PANG, J., 2013. Synthesis and neuroprotective action of xyloketal derivatives in Parkinson’s disease models. Marine Drugs, vol. 11, no. 12, pp. 5159-5189. http://dx.doi.org/10.3390/md11125159. PMid:24351912. http://dx.doi.org/10.3390/md11125159...
; Lu et al., 2010LU, X.L., YAO, X.L., LIU, Z., ZHANG, H., LI, W., LI, Z., WANG, G.L., PANG, J., LIN, Y., XU, Z., CHEN, L., PEI, Z. and ZENG, J., 2010. Protective effects of xyloketal B against MPP +-induced neurotoxicity in Caenorhabditis elegans and PC12 cells. Brain Research, vol. 1332, pp. 110-119. http://dx.doi.org/10.1016/j.brainres.2010.03.071. PMid:20347725. http://dx.doi.org/10.1016/j.brainres.201...
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Decreased degeneration of dopaminergic neurons |
Murine model C. elegans
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Increased worm survival |
C. elegans
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Attenuates mHtt protein aggregation |
C. elegans
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Zeng et al., 2016ZENG, Y., GUO, W., XU, G., WANG, Q., FENG, L., LONG, S., LIANG, F., HUANG, Y., LU, X., LI, S., ZHOU, J., BURGUNDER, J.-M., PANG, J. and PEI, Z., 2016. Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington’s disease. Drug Design, Development and Therapy, vol. 10, pp. 1443-1451. http://dx.doi.org/10.2147/DDDT.S94666. PMid:27110099. http://dx.doi.org/10.2147/DDDT.S94666...
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Aspergillus sp.
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Cyclopenol and cyclopenin |
Inhibits the synthesis of pro-inflammatory cytokines and improves learning deficits |
RAW-264.7 and Drosophila sp.
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Wang et al., 2020WANG, L., LI, M., LIN, Y., DU, S., LIU, Z., JU, J., SUZUKI, H., SAWADA, M. and UMEZAWA, K., 2020. Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin. The Journal of Antibiotics, vol. 73, no. 9, pp. 622-629. http://dx.doi.org/10.1038/s41429-020-0302-9. PMid:32210361. http://dx.doi.org/10.1038/s41429-020-030...
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6,8,1’-tri-O-metilaverantin |
Suppresses the synthesis of pro-inflammatory mediators |
Cells BV2 |
Kim et al., 2018KIM, K.W., KIM, H.J., SOHN, J.H., YIM, J.H., KIM, Y.C. and OH, H., 2018. Anti-neuroinflammatory effect of 6,8,1′-tri-O-methylaverantin, a metabolite from a marine-derived fungal strain Aspergillus sp., via upregulation of heme oxygenase-1 in lipopolysaccharide-activated microglia. Neurochemistry International, vol. 113, pp. 8-22. http://dx.doi.org/10.1016/j.neuint.2017.11.010. http://dx.doi.org/10.1016/j.neuint.2017....
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Aspergillus nidulans
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asperbenzaldehyde, asperthecin, 2,ω-dihydroxyemodin |
Inhibits the aggregation of tau filaments |
In vitro
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Paranjape et al., 2014PARANJAPE, S.R., CHIANG, Y.M., SANCHEZ, J.F., ENTWISTLE, R., WANG, C.C., OAKLEY, B.R. and GAMBLIN, T.C., 2014. Inhibition of Tau aggregation by three Aspergillus nidulans secondary metabolites: 2,ω-dihydroxyemodin, asperthecin, and asperbenzaldehyde. Planta Medica, vol. 80, no. 1, pp. 77-85. http://dx.doi.org/10.1055/s-0033-1360180. PMid:24414310. http://dx.doi.org/10.1055/s-0033-1360180...
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Isoquinoline |
Ingham et al., 2021INGHAM, D.J., BLANKENFELD, B.R., CHACKO, S., PERERA, C., OAKLEY, B.R. and GAMBLIN, T.C., 2021. Fungally derived isoquinoline demonstrates inducer-specific Tau aggregation inhibition. Biochemistry, vol. 60, no. 21, pp. 1658-1669. http://dx.doi.org/10.1021/acs.biochem.1c00111. PMid:34009955. http://dx.doi.org/10.1021/acs.biochem.1c...
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Aspergillus terreus
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extracts terreusterpenes |
Inhibits the action of the enzyme BACE-1 and AchE |
BACE-1 fluorescence resonance energy transfer and Ellman method, respectively |
Qi et al., 2018QI, C., QIAO, Y., GAO, W., LIU, M., ZHOU, Q., CHEN, C., LAI, Y., XUE, Y., ZHANG, J., LI, D., WANG, J., ZHU, H., HU, Z., ZHOU, Y. and ZHANG, Y., 2018. New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities from Aspergillus terreus. Organic & Biomolecular Chemistry, vol. 16, no. 46, pp. 9046-9052. http://dx.doi.org/10.1039/C8OB02741B. PMid:30430177. http://dx.doi.org/10.1039/C8OB02741B...
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Asperteretal F |
Inhibits TNF-a |
Cells BV-2 |
Yang et al., 2018YANG, L.-H., OU-YANG, H., YAN, X., TANG, B.W., FANG, M.J., WU, Z., CHEN, J.W. and QIU, Y.K., 2018. Open-ring butenolides from a marine-derived anti-neuroinflammatory fungus Aspergillus terreus Y10. Marine Drugs, vol. 16, no. 11, p. 428. http://dx.doi.org/10.3390/md16110428. PMid:30400195. http://dx.doi.org/10.3390/md16110428...
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Aspergillus terreus, Aspergillus flocculosus, Penicillium sp.
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4-Hydroxyscytalon, 4-hydroxy-6-dehydroxyscytalone and demethylcitreoviranol |
Inhibits ROS synthesis |
Cells neuro-2A |
Girich et al., 2020GIRICH, E.V., YURCHENKO, A.N., SMETANINA, O.F., TRINH, P.T.H., NGOC, N.T.D., PIVKIN, M.V., POPOV, R.S., PISLYAGIN, E.A., MENCHINSKAYA, E.S., CHINGIZOVA, E.A., AFIYATULLOV, S.S. and YURCHENKO, E.A., 2020. Neuroprotective metabolites from Vietnamese marine derived fungi of Aspergillus and Penicillium genera. Marine Drugs, vol. 18, no. 12, p. 608. http://dx.doi.org/10.3390/md18120608. PMid:33266016. http://dx.doi.org/10.3390/md18120608...
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