| 1 |
The role of Toll-like Receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis / Journal of the Pediatric Infectious Diseases Society / 2.2120(2019). |
Experimental/II |
Netea et al. (2002)NETEA, M.G., VAN DER GRAAF, C.A., VONK, A.G., VERSCHUEREN, I., VAN DER MEER, J.W. and KULLBERG, B.J., 2002. The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis. The Journal of Infectious Diseases, vol. 185, no. 10, pp. 1483-1489. http://dx.doi.org/10.1086/340511. PMid:11992285.
http://dx.doi.org/10.1086/340511...
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United Kingdom |
To evaluate the TLR4 role in the host defense in C. albicans infections. |
Mice with genetic defects that alter the TLR4-mediated response are more susceptible to infections caused by C. albicans. |
| 2 |
Expression and function of Toll-like receptors 2 and 4 in human keratinocytes / International Immunology / 3.5190(2019). |
Experimental/II |
Pivarcsi et al. (2003)PIVARCSI, A., BODAI, L., RÉTHI, B., KENDERESSY-SZABÓ, A., KORECK, A., SZÉLL, M., BEER, Z., BATA-CSÖRGOO, Z., MAGÓCSI, M., RAJNAVÖLGYI, E., DOBOZY, A. and KEMÉNY, L., 2003. Expression and function of Toll-like receptors 2 and 4 in human keratinocytes. International Immunology, vol. 15, no. 6, pp. 721-730. http://dx.doi.org/10.1093/intimm/dxg068. PMid:12750356.
http://dx.doi.org/10.1093/intimm/dxg068...
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United Kingdom |
To study the expression and function of TLR2 and TLR4 in human keratinocytes. |
NF-kB nuclear activation and transcription occurs in keratinocytes in response to microbial stimulation. This activation is necessary for the death of C. albicans. |
| 3 |
Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments / The EMBO Journal / 9.8890(2019). |
Experimental/II |
Gantner et al. (2005)GANTNER, B.N., SIMMONS, R.M. and UNDERHILL, D.M., 2005. Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. The EMBO Journal, vol. 24, no. 6, pp. 1277-1286. http://dx.doi.org/10.1038/sj.emboj.7600594. PMid:15729357.
http://dx.doi.org/10.1038/sj.emboj.76005...
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United States |
To determine the relevance of Dectin-1 in host defense against infections caused by Candida species. |
Dectin-1 is a receptor responsible for the identification and recognition of fungal PAMPs (B-glucan). |
| 4 |
Early-onset neutropenia is a risk factor for Candida colonization in
very low-birth-weight neonates / Diagnostic Microbiology and Infectious Disease / 2.4990(2019). |
Experimental/II |
Manzoni et al. (2007)MANZONI, P., FARINA, D., MONETTI, C., PRIOLO, C., LEONESSA, M., GIOVANNOZZI, C. and GOMIRATO, G., 2007. Early-onset neutropenia is a risk factor for Candida colonization in very low-birth-weight neonates. Diagnostic Microbiology and Infectious Disease, vol. 57, no. 1, pp. 77-83. http://dx.doi.org/10.1016/j.diagmicrobio.2006.10.018. PMid:17178299.
http://dx.doi.org/10.1016/j.diagmicrobio...
|
Netherlands |
To assess the role of early-onset neutropenia in the development of Candida colonization in preterm and low birth weight infants admitted to the NICU. |
Colonization in the first month of life was significantly higher in newborns with early-onset neutropenia, but sepsis rates did not differ compared to those without neutropenia. |
| 5 |
Developmental expression of Toll-like receptors-2 and -4 in preterm baboon lung / Developmental and Comparative Immunology / 3.1920(2019). |
Experimental/II |
Awasthi et al. (2008)AWASTHI, S., CROPPER, J. and BROWN, K.M., 2008. Developmental expression of Toll-like receptors-2 and -4 in preterm baboon lung. Developmental and Comparative Immunology, vol. 32, no. 9, pp. 1088-1098. http://dx.doi.org/10.1016/j.dci.2008.02.005. PMid:18377992.
http://dx.doi.org/10.1016/j.dci.2008.02....
|
United Kingdom |
To study the expression of TLR2 and TLR4 mRNA and proteins in lung tissue of premature baboons |
It has been observed that the expression of TLR2 and TLR4 is altered in cases of respiratory infection in premature baboons. |
| 6 |
Oxidative burst and phagocytosis of neonatal neutrophils confronting Candida albicans and Candida parapsilosis / Early Human Development / 1.9690(2019). |
Experimental/II |
Destin et al. (2009)DESTIN, K.G., LINDEN, J.R., LAFORCE-NESBITT, S.S. and BLISS, J.M., 2009. Oxidative burst and phagocytosis of neonatal neutrophils confronting Candida albicans and Candida parapsilosis. Early Human Development, vol. 85, no. 8, pp. 531-535. http://dx.doi.org/10.1016/j.earlhumdev.2009.05.011. PMid:19481378.
http://dx.doi.org/10.1016/j.earlhumdev.2...
|
Netherlands |
To compare the immunological capacity of neonatal neutrophils and adult neutrophils in the generation of an oxidative response against Candida species |
The oxidative response mediated by neonatal neutrophils exposed to C. albicans hyphae was similar to the response generated by adult neutrophils. |
| 7 |
Innate immune mechanisms for rw2ecognition and uptake of Candida species / Trends in Immunology / 13.4220(2019). |
Experimental/II |
Netea and Maródi (2010)NETEA, M.G. and MARÓDI, L., 2010. Innate immune mechanisms for recognition and uptake of Candida species. Trends in Immunology, vol. 31, no. 9, pp. 346-353. http://dx.doi.org/10.1016/j.it.2010.06.007. PMid:20705510.
http://dx.doi.org/10.1016/j.it.2010.06.0...
|
Netherlands |
Describe the molecular basis of the receptors involved in the recognition and death of C. albicans and the role of these receptors in the development of the inflammatory response |
Different PRRs are involved in the recognition, signaling, expression of proinflammatory cytokines and death of C. albicans, including TLRs, CLRs, NLRs, among others. |
| 8 |
Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages / Proceedings of the National Academy of Sciences / 9.4120(2019). |
Experimental/II |
Esteban et al. (2011)ESTEBAN, A., POPP, M.W., VYAS, V.K., STRIJBIS, K., PLOEGH, H.L. and FINK, G.R., 2011. Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages. Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 34, pp. 14270-14275. http://dx.doi.org/10.1073/pnas.1111415108. PMid:21825168.
http://dx.doi.org/10.1073/pnas.111141510...
|
United States |
Evaluate the interaction between Dectin-1 and galactin-3 in Candida species recognition. |
The association between Dectin-1 and galactin-3 facilitates the initiation of the inflammatory response from the synthesis and expression of inflammatory mediators such as TNF. |
| 9 |
Galectin-3 plays an important role in protection against disseminated candidiasis /Medical mycology / 2.8220(2019). |
Experimental/II |
Linden et al. (2013)LINDEN, J.R., DE PAEPE, M.E., LAFORCE-NESBITT, S.S. and BLISS, J.M., 2013. Galectin-3 plays an important role in protection against disseminated candidiasis. Medical Mycology, vol. 51, no. 6, pp. 641-651. http://dx.doi.org/10.3109/13693786.2013.770607. PMid:23488971.
http://dx.doi.org/10.3109/13693786.2013....
|
United Kingdom |
It was demonstrated that the association between these two receptors facilitates the initiation of the inflammatory response from the synthesis and expression of inflammatory mediators such as TNF. |
Mice deficient in galectin-3 (gal3 -/-) - compared to Wistar mice - were more susceptible to infection, died significantly faster, exhibited a trend of increased fungal load, increased abscess formation in brains and kidneys. |
| 10 |
Candidemia-induced pediatric sepsis and its association with free radicals, nitric oxide, and cytokine level in host / Journal of Critical Care / 2.6850(2019). |
Experimental/II |
Kumar et al. (2015)KUMAR, D., KUMAR, A., SINGH, S. and TILAK, R., 2015. Candidemia-induced pediatric sepsis and its association with free radicals, nitric oxide, and cytokine level in host. Journal of Critical Care, vol. 30, no. 2, pp. 296-303. http://dx.doi.org/10.1016/j.jcrc.2014.11.023. PMid:25634073.
http://dx.doi.org/10.1016/j.jcrc.2014.11...
|
United Kingdom |
To describe epidemiological data related to the susceptibility of sepsis induced by Candida species, non-albicans, in neonates hospitalized in the NICU, and the role of inflammatory mediators and reactive oxygen species in the neonatal immune response against these pathogens. |
The polymorphonuclear-mediated oxidative response and the role of inflammatory mediators such as nitric oxide, hydrogen peroxide, among others, were proven in this study. |
| 11 |
Galectin-3 binding protein in human preterm infant umbilical cord plasma/ Journal of Neonatal-Perinatal Medicine. |
Experimental/II |
Chan et al. (2015)CHAN, C., BODE, L. and KIM, J., 2015. Galectin-3 binding protein in human preterm infant umbilical cord plasma. Journal of Neonatal-Perinatal Medicine, vol. 8, no. 2, pp. 99-104. http://dx.doi.org/10.3233/NPM-15814055. PMid:26410432.
http://dx.doi.org/10.3233/NPM-15814055...
|
Netherlands |
Compare Gal3BP concentrations from samples obtained from umbilical cord blood from preterm and full-term neonates. |
Gal3BP concentrations are higher in preterms, in cases of gestational diabetes, prenatal steroid exposure, and increased maternal parity; and decreased in cases of chorioamnionitis. |
| 12 |
Reduced PICD in monocytes mounts altered neonate immune response to Candida albicans / PLoS ONE / 2.7400(2019). |
Experimental/II |
Dreschers et al. (2016)DRESCHERS, S., SAUPP, P., HORNEF, M., PREHN, A., PLATEN, C., MORSCHHÄUSER, J. and ORLIKOWSKY, T.W., 2016. Reduced PICD in monocytes mounts altered neonate immune response to Candida albicans. PLoS One, vol. 11, no. 11, e0166648. http://dx.doi.org/10.1371/journal.pone.0166648. PMid:27870876.
http://dx.doi.org/10.1371/journal.pone.0...
|
United States |
Determine whether TLR2 is involved in monocyte recognition of C. albicans.
|
TLR-2 has been shown to be a receptor implicated in the recognition of PAMPs (phospholipomannans) found in the cell wall in Candida albicans. |
| 13 |
Pretreatment with antibiotics impairs Th17-mediated antifungical immunity in newborns rats / Inflammation / 3.2120(2019). |
Experimental/II |
Wang et al. (2020)WANG, P., YAO, J., DENG, L., YANG, X., LUO, W. and ZHOU, W., 2020. Pretreatment with antibiotics impairs Th17-mediated antifungal immunity in newborn rats. Inflammation, vol. 43, no. 6, pp. 2202-2208. http://dx.doi.org/10.1007/s10753-020-01287-w. PMid:32623554.
http://dx.doi.org/10.1007/s10753-020-012...
|
United States |
Using an animal model to demonstrate how the use of antibiotics affects the antifungal immune function and promotes susceptibility. |
The use of antibiotics significantly decreased the ability of newborn rats to develop an effective antifungal response. |
| 14 |
Fungal cutaneous microbiome and host determinants in preterm and term neonates / Pediatric Research / 2.7470(2019). |
Experimental/II |
Paul et al. (2020)PAUL, A.A., HOFFMAN, K.L., HAGAN, J.L., SAMPATH, V., PETROSINO, J.F. and PAMMI, M., 2020. Fungal cutaneous microbiome and host determinants in preterm and term neonates. Pediatric Research, vol. 88, no. 2, pp. 225-233. http://dx.doi.org/10.1038/s41390-019-0719-7. PMid:31816621.
http://dx.doi.org/10.1038/s41390-019-071...
|
United States |
To characterize the skin microbiota of preterm newborns and compare it with the microbiota of full-term newborns to describe the clinical and host determinants that influence its diversity. |
The alpha microbiota diversity was influenced by exposure to antibiotics and the environment of the Intensive Care Unit; The diversity of the beta microbiota varied according to mode of delivery, diet and location in the body. |
