No. of animals Dose (mg/kg) Sample timeaTS A Sex No. of analyzed PCE mPCE/1000 PCE (individual data)Mean ± SD PCE/NCE ± SD N. Control 4 4 4 M 8,000 3.5, 3, 4.5, 3.5 3.6 ± 1.30 0.86 ± 0.42 5 5 5 F 10,000 5, 5.5, 4.5, 0, 1 3.0 ± 2.71 1.10 ± 0.52 PA 24 h 5 5 4 M 8,000 5, 8, 8.5, 4.5 6.5 ± 2.38* 0.50 ± 0.16 (18.75) 5 5 5 F 10,000 1, 4, 4, 1, 2 2.4 ± 1.52 0.48 ± 0.23 48 h 5 5 5 M 10,000 6, 5, 4, 2.5, 5 4.6 ± 1.67 0.65 ± 0.17 5 5 5 F 10,000 4, 8, 5, 6, 4 5.4 ± 1.67* 0.52 ± 0.18 72 h 5 4 4 M 8,000 8, 4, 4, 4 5.0 ± 2.00* 0.70 ± 0.18 5 5 5 F 10,000 2.5, 6, 4, 5, 3.5 4.2 ± 1.48 0.60 ± 0.43 PA 24 h 5 5 4 M 8,000 5.5, 2.3, 5.5, 3 4.0 ± 1.67 0.79 ± 0.14 (37.50) 5 5 5 F 10,000 8.5, 4.5, 3.5, 3.5, 7.6 5.5 ± 2.37* 0.78 ± 0.16 48 h 5 5 5 M 10,000 6, 6, 6.5, 8.5, 7 6.8 ± 1.30* 0.85 ± 0.44 5 5 5 F 10,000 0.5, 3.5, 4.5, 3, 5 3.3 ± 1.75 0.76 ± 0.38 72 h 5 4 4 M 8,000 2.5, 3, 2.5, 3.5 2.9 ± 0.48 0.54 ± 0.28 5 5 5 F 10,000 5, 3, 2, 3, 6 3.8 ± 1.64 0.55 ± 0.20 P. Control 24 h 9 9 9 M 18,000 23, 19, 31, 18, 28.19, 34.5, 23, 22.3 24.2 ± 5.76* 0.61 ± 0.22 7 7 7 F 14,000 33, 16, 18, 13.5, 20, 40, 27.3 24.0 ± 9.78* 0.59 ± 0.19 48 h 5 5 5 M 10,000 15.5, 17, 13, 9.5, 11.5 13.3 ± 3.01* 0.31 ± 0.06* 5 5 5 F 10,000 15, 12.5, 6.5, 11, 8 10.6 ± 3.42* 0.39 ± 0.30*
Dose (mg/kg) Sample timeaNo. of animals Sex No. of analyzed PCE mPCE/1000 PCE (individual data) Means ± SD PCE/NCE ± SD T S A N. Control 9 9 8 M 24,000 3, 3, 1, 3.5, 2.5, 1, 1.5, 0 1.9 ± 1.24 55.20 ± 17.98 10 10 10 F 25,000 1, 1, 2, 2, 1, 0, 1, 0.5, 1, 1 1.0 ± 0.60 76.20 ± 26.18 PA 24 h 5 5 4 M 8,000 8.6, 4.6, 7.5, 7.5 7.1 ± 1.71* 66.00 ± 42.70 (18.75) 5 5 4 F 6,000 1, 1, 2, 2 1.5 ± 0.58 46.00 ± 12.98* 48 h 11 11 10 M 17,000 3, 2.5, 2.5, 2, 3, 1, 1, 1, 3, 1 2.0 ± 0.91 53.82 ± 22.71 10 10 10 F 14,000 1.5, 2.5, 1, 3, 1, 0, 4.2, 1, 1 1.7 ± 1.18 60.38 ± 24.24 72 h 5 4 4 M 5,000 2, 1, 4, 4 2.3 ± 1.99 61.50 ± 20.61 5 5 5 F 5,000 2, 2, 1, 1, 1 1.4 ± 0.55 52.60 ± 12.78 4 d 6 6 6 M 6,000 0, 3, 1, 0, 1, 5 1.7 ± 1.97 75.33 ± 18.99 5 5 5 F 5,000 4, 1, 1, 3, 4 2.6 ± 1.52* 73.20 ± 22.95 7 d 6 6 4 M 4,000 1, 0, 1, 0 0.5 ± 0.58 87.80 ± 61.11 5 5 4 F 4,000 0, 1, 0, 0 0.3 ± 0.50 56.40 ± 12.99 14 d 6 6 5 M 5,000 4, 4, 2, 1, 1 2.4 ± 1.52 55.20 ± 30.24 5 5 4 F 4,000 2, 1, 1, 2 1.5 ± 0.58 43.40 ± 28.17 21 d 6 6 5 M 5,000 0, 0, 1, 0, 0 0.2 ± 0.45 61.17 ± 15.00 5 5 5 F 5,000 2, 0, 0, 0, 1, 0 0.6 ± 0.89 53.25 ± 2.99 PA 24 h 5 4 4 M 8,000 3.5, 7.5, 1.5, 6.5 4.7 ± 2.92* 41.80 ± 8.66 (37.50) 5 5 5 F 5,000 6, 6, 2, 2, 7 4.6 ± 2.41* 57.80 ± 32.97 48 h 12 12 10 M 14,000 5.5, 4, 7, 7, 10, 6, 4, 10, 7, 11 7.2 ± 2.47* 46.60 ± 23.86 11 11 11 F 15,000 2.5, 5, 6, 6.5, 6.5, 7, 12, 4, 5, 5, 1 5.5 ± 2.81* 50.50 ± 13.16 72 h 5 4 4 M 7,000 4.5, 3.5, 4, 2 3.5 ± 1.27 38.00 ± 10.12 5 5 5 F 7,000 3, 1, 4, 1.5, 5 2.9 ± 1.67* 45.70 ± 5.86* 4 d 7 6 6 M 6,000 3, 2, 3, 2, 3, 3 2.7 ± 0.52 99.00 ± 25.18* 6 6 6 F 5,000 2, 1, 6, 0, 0, 1 1.7 ± 2.25 93.80 ± 12.00 7 d 7 6 5 M 5,000 1, 0, 2, 5, 6 2.8 ± 2.59 29.00 ± 1.73* 6 6 4 F 4,000 1, 1, 1, 2 1.3 ± 0.50 37.00 ± 9.86* 14 d 7 6 5 M 5,000 0, 1, 3, 1, 2 1.4 ± 1.14 63.40 ± 19.76 6 6 5 F 5,000 1, 4, 3, 2, 1 2.2 ± 1.30 49.20 ± 19.03 21 d 7 6 5 M 5,000 2, 0, 0, 0, 0 0.4 ± 0.89 63.50 ± 15.72 6 6 6 F 6,000 0, 0, 0, 0, 1, 0 0.2 ± 0.41 47.80 ± 7.86* P. Ccontrol 24 h 5 5 5 M 5,000 9, 10, 9, 5, 12 9.0 ± 2.55* 5 5 5 F 9,000 10, 9, 9, 9.5, 10 9.5 ± 0.50* 48 h 5 5 5 F 5,000 23, 35, 24, 26, 29 27.5 ± 4.83* 46.20 ± 12.40 5 5 5 F 5,000 13, 19, 22, 12, 21 17.4 ± 4.62* 37.40 ± 13.26*