The role of microRNAs in enteroviral infections

Wu, Jing; Shen, Li; Chen, Jianguo; Xu, Huaxi; Mao, Lingxiang

doi:10.1016/j.bjid.2015.06.011

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Brazilian Journal of Infectious Diseases

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REVIEW ARTICLES • Braz J Infect Dis 19 (5) • Sep-Oct 2015 • https://doi.org/10.1016/j.bjid.2015.06.011 copy

The role of microRNAs in enteroviral infections

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

The genus Enterovirus, a member of thePicornavirus family, are RNA viruses that can cause poliomyelitis, hand-food-mouth disease, viral meningitis or meningoencephalitis, viral myocarditis and so on. MicroRNAs are a class of highly conserved, small noncoding RNAs recognized as important regulators of gene expression. Recent studies found that MicroRNAs play a significant role in the infection ofEnterovirus, such as enterovirus 71, coxsackievirus B3 and other Enterovirus. Enteroviral infection can alter the expression of cellular MicroRNAs, and cellular MicroRNAs can modulate viral pathogenesis and replication by regulating the expression level of viral or host's genes. Herein, this review summarizes the role of MicroRNAs in enteroviral infection.

Keywords:
MicroRNAs; Enterovirus; Infection

miRNAs	Function	Target	Ref.
miR-296-5p	Repression of viral replication	EV71 VP3 and VP1-coding region	37
miR-23b	Repression of viral replication	EV71 3' UTR	38
miR373 and miR542-5p	Repression of viral replication	EV71 5' UTR	39
miRNA-548	Enhancement of replication of EV71 and VSV	IFN-?1	41
miR-146a	Enhancement of viral pathogenesis	IRAK1 and TRAF6	42
miR-526a	Repression of viral replication	CYLD	43
miR-146a and miR-370	Enhancement of EV71-induced cell apoptosis	SOS1and GADD45ß	44
miR-141	Enhancement of EV propagation	eIF4E	45
miR-27a	Repression of viral replication	EGFR	46
miR-1246	Contribution to the neurological pathogenesis	DLG3	47

miRNA	Function	Target	Ref.
miR-146a, miR-21, miR-374, miR-29a*, miR-23a	Regulation of pathogenesis of CVB3-Induced VMC	Unknown	48
miR-342-5p	Repression of CVB3 replication	CVB3 2C-coding region	49
miR-10a*	Enhancement of viral replication	CVB3 3D-coding region	50
MiR-203	Enhancement of viral replication	ZFP-148	51
MiR-155	Enhancement of myocardial inflammation response	PU.1	53
miR-126	Promotion of viral replication	SPRED1, LRP6, and WRCH1	55
miR-1	Interference of cardiac function	Cx43	56
miR-21	Alleviation of CVB3-induced myocarditis	PDCD4	57
miR-21 and miR-146b	Regulation of viral pathogenesis	ROP?t	58
miR-21	Enhancement of viral pathogenesis	YOD1 and VCL	59
miR-21	Enhancement of viral pathogenesis	SPRY1	60

miRNA	Verified functions of the miRNA	Verified targets	Ref.
miR-342-5p	Repression of viral replication	CVB3 2C-coding region	38
miR-10a*	Enhancement of viral replication	CVB3 3D-coding region	39
MiR-203	Enhancement of viral replication	ZFP-148	40
MiR-155	Enhancement of myocardial inflammation response	PU.1	42
miR-126	Promotion of viral replication	SPRED1, LRP6, and WRCH1 genes	44
miR-1	Involved in viral myocarditis	Cx43	45
miR-21	Alleviation of CVB3-induced myocarditis	PDCD4	46
miR-21 and miR-124b	Regulation of viral pathogenesis	ROP?t	47
miR-21	Enhancement of viral pathogenesis	YOD1 and VCL	48
miR-21	Enhancement of viral pathogenesis	SPRY1	49

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[1] *Corresponding author at: Department of Clinical Laboratory, Zhenjiang Center for Disease Control and Prevention, Zhenjiang 212003, Jiangsu Province, China. E-mail address: maolingxiang@aliyun.com (L. Mao).