Sahana M. Srinivas, G.C. Marlursiddappa Pradeep, 2018. India1414 Srinivas S.M., Pradeep G.C. Congenital chikungunya infection presenting with extensive dystrophic calcinosis cutis. Indian J Dermatol Venereol Leprol. 2020;86:693-6.
|
1 |
Male |
11 days old fever, poor feeding, presumed sepsis, hyperpigmented macules on face and trunk, multiple small necrotic ulcers |
Supportive measures and physiotherapy |
Extensive dystrophic calcifications, atrophic scars and no deformities |
Shen et al., 2021 China and Myanmar1515 Shen J.-.Y., Li M., Xie L., Mao J.-.R., Zhou H.-.N., Wang P.-.G., et al. Perinatal Vertical Transmission of Chikungunya Virus in Ruili, a Town on the Border between China and Myanmar. Virol Sin. 2021;36:145-8.
|
3 |
2 males and 1 female |
Disseminated maculopapular rash, fever, drowsiness, arthralgia |
Antibiotics, antypretic. The female baby received antiviral treatment (IFNB-1a 800,000 IU bid) |
They progressed favorably and was discharged asymptomatic |
Fajardo et al., 2021. Brazil1616 Fajardo T.C.G., Gazeta R.E., Catalan D.T., Mello A.S., Silva ACBd, Bertozzi A.P.A.P., et al. Neonatal consequences of maternal exposure to the chikungunya virus: case reports. Medicine (Baltimore). 2021;100:e25695.
|
2 |
Females |
No symptoms in the first weeks of life. Developmental delay observed from 83 days of life. |
Clinical monitoring of neurodevelopment |
Neurocognitive delay up to 3 years of age |
Sreekanth et al., 2022. India1717 Sreekanth R., Venugopal L., Arunkrishnan B., Chaturvedi S., Sundaram S. Neonatal chikungunya encephalitis. Case report. Trop Doct. 2022;52:199-201.
|
1 |
Female |
Six-day old late onset sepsis, seizures, cranial hemorrhage, maculopapular rash, perioral hyperpigmenation |
Phenobarbital, fresh frozen plasma, red blood cell transfusion, IVIG 1 g/Kg on the 7th and 9th days of admission |
On follow up at three months, neurological examination was normal |
Faustino et al., 2022. Brazil1818 Faustino R., Carvalho F.R., Medeiros T., Familiar-Macedo D., Vianna R.A.O., Leite P.E.C., et al. Pro-inflammatory profile of children exposed to maternal chikungunya virus infection during the intrauterine period: a one-year follow-up study. Viruses. 2022;14:1881.
|
33 |
57.6 % male |
Fever (79 %), myalgia (100 %), arthralgia (100 %) One presented neurodevelopment delay and one presented pos natal sepsis |
Not described |
At 3-months only one child presented neurological alterations |
Torres et al., 2022. Brazil1919 Torres M.C., Di Maio F., Brown D., Spyer M., Nastouli E., Brasil P., et al. In depth viral diversity analysis in atypical neurological and neonatal chikungunya infections in Rio de Janeiro, Brazil. Viruses. 2022;14:2006.
|
3 |
3 females |
Fever, jaundice, thrombocytopenia, apnea, seizures, maculopapular rash |
Antibiotics |
One baby evolved with altered brain image on magnetic resonance |
Sagay, et al. 2024. Nigeria2020 Sagay A.S., Hsieh S.-.C., Dai Y.-.C., Chang C.A., Ogwuche J., Ige O.O., et al. Chikungunya virus antepartum transmission and abnormal infant outcomes in a cohort of pregnant women in Nigeria. Int J Infect Dis. 2024;139:92-100.
|
26 |
Not described |
Not described |
Not described |
Three stillbirths, two multiple congenital anomalies, one polydactyly with sepsis and jaundice, and one preterm |