(Nkenfou, Nemes E, Mekue L, Grifoni A, Dambaya B, 2015)2525 Nemes E, Mekue L, et al. Human leucocyte antigen class I diversity among human immunodeficiency virus exposed negative and positive children in Cameroon. J AIDS Clin Res. 2015;06.
|
Cohort |
28 = EU 34 = INF |
HLA-B *44 |
Cameroon |
Associated with resistance to MTCT of HIV |
(Adland et al., 2015)1010 Adland E, Paioni P, Thobakgale C, et al. Discordant impact of HLA on viral replicative capacity and disease progression in pediatric and adult HIV infection. PLoS Pathog. 2015;11:1-26.
|
Cohort |
47 = TR 84 = INF |
HLA-B *45:01 HLA-B *18:01 HLA-B *58:02 |
Kimberley, South Africa. |
Viral replicative capacity was higher in children born to mothers expressing any of these alleles that increase risk of disease. |
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HLA-B *57 HLA-B *58:01 HLA-B *81:01 |
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A modest decrease in viral replicative capacity in children expressing these alleles. |
(Paximadis et al., 2011)3939 Paximadis M, Minevich G, Winchester R, et al. KIR-HLA and maternal-infant HIV-1 transmission in sub-Saharan Africa. PLoS ONE. 2011;6.
|
Cases and controls |
150 = NT 150 = EU 72 = INF 74 = TR |
Homozygous for HLA-B1
|
Johannesburg, South Africa |
Greater representation in IP than in EU. |
|
|
|
HLA-B *08:01 |
|
Smaller representation in INF than in EU. |
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|
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HLA-B *14:02 |
|
Greater representation in TR than in NT. |
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|
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HLA-B *42:01 |
|
Smaller representation in TR than in NT. |
(Arnaiz-Villena et al., 2009)2424 Arnaiz-Villena A, Martín-Villa JM, Amador JTR, et al. Risk of vertical HIV transmission combines the "B35-Cw4 disadvantage" and the "pattern of inheritance" theories of progression. Curr HIV Res. 2009;7:314-9.
|
Cases and controls |
63 = INF 57 = EU 31 = TR 36 = NT 175 = Controls |
HLA-B *35 |
Spain |
Consistent association with allele expression and development of AIDS in children. |
(Schneidewind et al., 2009)22 Levy JA. In: Levy JA, editor. HIV and the pathogenesis of AIDS, vol. 1, 3rd ed. Address Editorial; 2007, 680 p.
|
Cohort |
13 = TR 13 = INF |
HLA-B *57 |
Jamaica Barbados Haiti |
HLA-B expression confers a consistent benefit on viral control during childhood that is independent of parental inheritance (mothers or fathers). |
(Thobakgale et al., 2009)1111 Thobakgale CF, Prendergast A, Crawford H, et al. Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection. J Virol. 2009;83:10234-44.
|
Cohort |
61 = TR 61 = INF 236 = NT |
HLA-B *81:01 |
Durban, South Africa |
Slow progression of disease in INF, particularly when these protective HLA alleles were not shared with the mother. |
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HLA-B *58:01 |
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HLA-B *57 |
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|
(Winchester et al., 2004)1212 Winchester R, Pitt J, Charurat M, et al. Mother-to-child transmission of HIV-1: strong association with certain maternal HLA-B alleles independent of viral load implicates innate immune mechanisms. J Acquir Immune Defic Syndr. 2004;36:659-70.
|
Cases and controls |
163 = NT 163 = EU 83 = INF 83 = TR |
HLA-B *35:01 HLA-B *35:03 |
Prospective Multicentric Cohort WITS |
These alleles expression was more frequent among TR than in NT. Increased risk of transmission was found mainly among cases with low viral loads. |
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HLA-B *44:02 |
|
Increased transmission rates among African-American and Hispanic mothers. |
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HLA-B *14:02 |
|
HLA-B*14:02 expression was associated with increased MTCT rate. |
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|
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HLA-B *13:02 |
|
HLA-B *13:02 expression was associated with increased MTCT. |
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|
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HLA-B *50:01 |
|
This allele expression was predominant among Hispanic mothers, and was associated with increased transmission in this ethnic group. |
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HLA-B *49:01 HLA-B *53:01 |
|
Lower risk of vertical transmission of HIV-1 in mothers with high viral loads. |
(Kuhn et al., 2004)2222 Kuhn L, Abrams EJ, Palumbo P, et al. Maternal versus paternal inheritance of HLA class I alleles among HIV-infected children: consequences for clinical disease progression. Aids. 2004;18:1281-9.
|
Cohort |
59 = INF 59 = TR |
Homozygous for HLA-B1
|
New York |
Patients expressing this allele were three times more likely to develop AIDS or death in children. |
|
|
|
HLA-B *27 HLA-B *57 |
|
These alleles expression was associated with lower risk of AIDS or death when they were inherited from the father. |
(Farquhar et al., 2004)2626 Farquhar C, Rowland-Jones S, Mbori-Ngacha D, et al. Human leukocyte antigen (HLA) B*18 and protection against mother-to-child HIV type 1 transmission. AIDS Res Hum Retroviruses. 2004;20:692-7.
|
Cohort |
76 = INF 357 = EU |
HLA B *18 |
Kenia, Nairobi |
The allele expression was protective against early acquisition of HIV-1. No infants expressing the allele have acquired HIV-1 after one month of birth, suggesting that they may protect against late infection through breastfeeding. |