Tripanosoma cruzi
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Epimastigote (strain Dm28c) |
LD50 < 3.1 μM - 72 h |
4646 Jorqueira A, Gouvea RM, Ferreira VF, da Silva MN, de Souza MC, Zuma AA, et al. Oxyrane derivative of α-lapachone is potent growth inhibitor of Trypanosoma cruzi epimastigote forms. Parasitol Res. 2006;99:429–33.
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IC50 = 1.3 μM - 72h |
4747 Ferreira VF, Jorqueira A, Souza AM, da Silva MN, de Souza MC, Gouvea RM, et al. Trypanocidal agents with low cytotoxicity to mammalian cell line: a comparison of the theoretical and biological features of lapachone derivatives. Bioorg Med Chem. 2006;14:5459–66.
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Growth inhibition (100%) - 72 h |
4848 Bourguignon SC, Cavalcanti DF, de Souza AM, Castro HC, Rodrigues CR, Albuquerque MG, et al. Trypanosoma cruzi: insights into naphthoquinone effects on growth and proteinase activity. Exp Parasitol. 2011;127:160–6.
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Epimastigote (strain Y) |
IC50 = 0.05 μM - 72 h |
3939 Carneiro PF, do Nascimento SB, Pinto AV, Pinto MCFR, Lechuga GC, Santos DO, et al. New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms. Bioorg Med Chem Lett. 2012;20:4995–5000.
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Tripomastigote (strain Y) |
Growth inhibition (97%) - 72h |
4949 Bourguignon SC, Castro HC, Santos DO, Alves CR, Ferreira VF, Gama IL, et al. Trypanosoma cruzi: in vitro activity of Epoxy-alpha-Lap, a derivative of alpha-lapachone, on trypomastigote and amastigote forms. Exp Parasitol. 2009;122:91–6.
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Tripomastigote (strain Colombiana) |
Growth inhibition (84%) - 72 h |
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Intracellular amastigote (strain Y) |
Human macrophages:
Growth inhibition (85.6%) – 72 h
VERO Cell:
Growth inhibition (96.4%) – 72 h
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Intracellular amastigote (strain Colombian) |
Human macrophages:
Growth inhibition (71.9%) – 72 h
VERO Cell:
Growth inhibition (95.0%) – 72 h
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Leishmania (Leishmania) amazonensis (strain MHOM/BR/73/LTB0016) |
Promastigote |
<b>IC50:</b> |
3131 Souza-Silva F, do Nascimento SB, Bourguignon SC, Pereira BA, Carneiro PF, da Silva WS, et al. Evidence for leishmanicidal activity of the naphthoquinone derivative epoxy-α-lapachone. Exp Parasitol. 2014;147:81–4.
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L. (L.) braziliensis: 37.0 ± 0.4 μM – 24 h |
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Leishmania (Viannia) braziliensis (strain MCAN/BR/1998/R619)
L. (L.) amazonensis: 37.0 ± 0.4 μM – 24 h
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Intracellular amastigote |
Human macrophages - IE:
L. (L.) braziliensis: 21.0 ± 2
L. (L.) amazonensis: 6.0 ± 0.8
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Plasmodium falciparum
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Erythrocytic form(strain 3D7) |
IC50 = 3.71 μM - 48 h |
3737 Carneiro PF, Pinto MCRF, Marra RKF, da Silva FC, Resende JALC, Rocha E, Silva LF, et al. Synthesis and antimalarial activity of quinones and structurally-related oxirane derivatives. Eur J Med Chem. 2016;108:134–40.
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