Cysteine-aspartic proteases (Caspase) |
Breast cancer |
Apoptosis induction |
(6363. Levine AJ. p53: 800 million years of evolution and 40 years of discovery. Nat Rev Cancer 2020; 20: 471-480, doi: 10.1038/s41568-020-0262-1. https://doi.org/10.1038/s41568-020-0262-...
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Bladder cancer |
Apoptosis induction, Anti-proliferation |
(6767. Kim SO, Cha HJ, Park C, Lee H, Hong SH, Jeong SJ, et al. Cordycepin induces apoptosis in human bladder cancer T24 cells through ROS-dependent inhibition of the PI3K/Akt signaling pathway. Biosci Trends 2019; 13: 324-333, doi: 10.5582/bst.2019.01214. https://doi.org/10.5582/bst.2019.01214...
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|
Brain cancer |
Apoptosis induction Cell cycle arrest |
(6868. Chaicharoenaudomrung N, Jaroonwitchawan T, Noisa P. Cordycepin induces apoptotic cell death of human brain cancer through the modulation of autophagy. Toxicol in Vitro 2018; 46: 113-121, doi: 10.1016/j.tiv.2017.10.002. https://doi.org/10.1016/j.tiv.2017.10.00...
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|
Liver cancer |
Apoptosis induction |
(8181. Shao LW, Huang LH, Yan S, Jin JD, Ren SY. Cordycepin induces apoptosis in human liver cancer HepG2 cells through extrinsic and intrinsic signaling pathways. Oncol Lett 2016; 12: 995-1000, doi: 10.3892/ol.2016.4706. https://doi.org/10.3892/ol.2016.4706...
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|
Lung cancer |
Apoptosis induction, Anti-proliferation, Anti-metastasis |
(8282. Tao X, Ning Y, Zhao X, Pan T. The effects of cordycepin on the cell proliferation, migration and apoptosis in human lung cancer cell lines A549 and NCI-H460. J Pharm Pharmacol 2016; 68: 901-911, doi: 10.1111/jphp.12544. https://doi.org/10.1111/jphp.12544...
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|
Prostate cancer |
Apoptosis induction |
(8383. Kazuya K, Takumi S, Ryosuke M, Takumi N, Koichiro O, Mana A, et al. Cordyceps militaris extract and the main component, Cordycepin, modulate the functions of prostate cancer cells partially through the adenosine A1 receptor. Nat Prod Commun 2022; 17: 1934578x221130859, doi: 10.1177/1934578x221130859. https://doi.org/10.1177/1934578x22113085...
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|
Leukemia |
Apoptosis induction |
(8484. Liang SM, Lu YJ, Ko BS, Jan YJ, Shyue SK, Yet SF, et al. Cordycepin disrupts leukemia association with mesenchymal stromal cells and eliminates leukemia stem cell activity. Sci Rep 2017; 7: 43930, doi: 10.1038/srep43930. https://doi.org/10.1038/srep43930...
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Jun NH2-terminal kinases (JNK) |
Colon cancer |
Cell cycle arrest |
(2222. Khuntawee W, Amornloetwattana R, Vongsangnak W, Namdee K, Yata T, Karttunen M, et al. In silico and in vitro design of cordycepin encapsulation in liposomes for colon cancer treatment. RSC Adv 2021; 11: 8475-8484, doi: 10.1039/D1RA00038A. https://doi.org/10.1039/D1RA00038A...
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Oral Cancer |
Apoptosis induction |
(3636. Tung KL, Wu SZ, Yang CC, Chyang HY, Chang CS, Wang YH, et al. Cordycepin induces apoptosis through JNK-mediated caspase activation in human OEC-M1 oral cancer cells. Evid Based Complement Alternat Med 2022; 2022: 1842363, doi: 10.1155/2022/1842363. https://doi.org/10.1155/2022/1842363...
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|
Bladder cancer |
Cell cycle arrest |
(8686. Oh SS, Lee KW, Madhi H, Jeong JW, Park S, Kim M, et al. Cordycepin resensitizes T24R2 cisplatin-resistant human bladder cancer cells to cisplatin by inactivating Ets-1 dependent MDR1 transcription. Int J Mol Sci 2020; 21: 1710, doi: 10.3390/ijms21051710. https://doi.org/10.3390/ijms21051710...
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|
Lung cancer |
Apoptosis induction, Anti-proliferation, Anti-metastasis |
(5656. Joo JC, Hwang JH, Jo E, Kim YR, Kim DJ, Lee KB, et al. Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinoma. Oncotarget 2017; 8: 12211-12224, doi: 10.18632/oncotarget.14661. https://doi.org/10.18632/oncotarget.1466...
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Nuclear factor-κB (NF-κB) |
Ovarian cancer |
Apoptosis induction |
(2323. Cui ZY, Park SJ, Jo E, Hwang IH, Lee KB, Kim SW, et al. Cordycepin induces apoptosis of human ovarian cancer cells by inhibiting CCL5-mediated Akt/NF-κB signaling pathway. Cell Death Discov 2018; 4: 62, doi: 10.1038/s41420-018-0063-4. https://doi.org/10.1038/s41420-018-0063-...
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|
Lung cancer |
Apoptosis induction, Anti-proliferation |
(3232. Zhang C, Zhong Q, Zhang XF, Hu DX, He XM, Li Ql, et al. Effects of cordycepin on proliferation, apoptosis and NF-κB signaling pathway in A549 cells [in Chinese]. Zhong Yao Cai 2015; 38: 786-789.) |
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Renal cancer |
Apoptosis induction |
(3737. Hwang IH, Oh SY, Jang HJ, Jo E, Joo JC, Lee KB, et al. Cordycepin promotes apoptosis in renal carcinoma cells by activating the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression. PloS One 2017; 13: e0191535, doi: 10.1371/journal.pone.0186489. https://doi.org/10.1371/journal.pone.018...
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