Koenigsberg et al. 2012 (4040. Koenigsberg HW, Yuan P, Diaz GA, Guerreri S, Dorantes C, Mayson S, et al. Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients. Psychiatry Res 2012; 199: 92-97, doi: 10.1016/j.psychres.2012.04.026. https://doi.org/10.1016/j.psychres.2012....
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Analyze BDNF levels in patients with BPD. |
Analysis of BDNF platelet levels in 24 patients with BPD (33% females/age: 37.9 (9.2)), compared to 18 healthy controls (38% females, age: 29.9 (7.4)). |
Decreased BDNF level in platelets of male patients with BPD (P<0.01). |
Perroud et al. 2013 (4141. Perroud N, Salzmann A, Prada P, Nicastro R, Hoeppli ME, Furrer S, et al. Response to psychotherapy in borderline personality disorder and methylation status of the BDNF gene. Transl Psychiatry 2013; 3: e207, doi: 10.1038/tp.2012.140. https://doi.org/10.1038/tp.2012.140...
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Investigate methylation status of exons I and IV in BPD patients and BDNF levels. |
Blood analysis of 115 patients with BPD (93.91% females/age: 30.36 (9.19)) and compared to 52 controls (46.15% females/age: 40.65 (12.04)). |
Higher BDNF level in plasma of patients with BPD (P<0.01). |
Kahl et al.2005 (4949. Kahl KG, Rudolf S, Stoeckelhuber BM, Dibbelt L, Gehl HB, Markhof K, et al. Bone mineral density, markers of bone turnover, and cytokines in young women with Borderline personality disorder with and without comorbid major depressive disorder. Am J Psychiatry 2005; 162: 168-174, doi: 10.1176/appi.ajp.162.1.168. https://doi.org/10.1176/appi.ajp.162.1.1...
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Investigate bone density and immune markers in women with BPD. |
Measurement of immune markers in blood of 16 women with BPD (age: 25.9 (5.0)), 12 women with BPD and depression during their lifetime (age: 31.8 (6.5)), and 10 women with BPD and depression currently facing the pathology (age: 24.2 (5.9)) compared to 20 healthy women (age: 26.1 (5.1)). |
Higher levels of TNF-α and IL-6 in patients with BPD and current depression (P<0.05). |
Kahl et al. 2006 (5050. Kahl KG, Bens S, Ziegler K, Rudolf S, Dibbelt L, Kordon A, et al. Cortisol, the cortisol-dehydroepiandrosterone ratio, and pro-inflammatory cytokines in patients with current major depressive disorder comorbid with Borderline personality disorder. Biol Psychiatry 2006; 59: 667-671, doi: 10.1016/j.biopsych.2005.08.001. https://doi.org/10.1016/j.biopsych.2005....
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Examine plasma cortisol profile, cytokines and cortisol/DHEA ratio in patients with BPD and depression. |
Serum level analysis of cortisol, DHEA, TNF-α, IL-6, IL1β in 12 women with BPD and depression (age: 25.6 (3.9)), compared to 12 healthy women (age: 26.3 (5.1)). |
Higher levels of TNF-α and IL-6 in patients with BPD and depression (P<0.05). |
Lee et al. 2020 (6666. Lee RJ, Gozal D, Coccaro EF, Fanning J. Narcissistic and Borderline personality disorders: relationship with oxidative stress. J Pers Disord 2020; 34: 6-24, doi: 10.1521/pedi.2020.34.supp.6. https://doi.org/10.1521/pedi.2020.34.sup...
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Investigate if individuals with personality disorders had changes in 8-OH-DG concentration. |
Measurement of 8-OH-DG blood levels in 98 individuals with mental disorders: 43 with BPD (68.3% females/age: 36.33 (8.64), 29 with mental disorders other than personality disorders (65.5% females/age: 35.76 (6.26)) compared to 68 healthy controls (55% females/age: 32 (9.08)). |
Higher levels of 8-OH-DG in whole blood of patients with BPD (P<0.01). |
MacDowell et al. 2020 (6767. MacDowell KS, Marsá MD, Buenache E, Villatoro JML, Moreno B, Leza JC, et al. Inflammatory and antioxidant pathway dysfunction in borderline personality disorder. Psychiatry Res 2020; 284: 112782, doi: 10.1016/j.psychres.2020.112782. https://doi.org/10.1016/j.psychres.2020....
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Investigate changes in inflammatory and oxidative responses in patients with BPD. |
Measurement of serum levels of TBARS, nitrites, and antioxidant enzymes and investigation of intracellular components involved withinflammation and oxidation (IκBα, NFκB, iNOS, COX2, Keap1, NQO1, and HO1) in 49 patients with BPD (87.8% females/age: 29.8) and 33 healthy controls (93.8% females/age: 30.5)). |
Decreased levels of antioxidant enzymes (CAT, GPx, and SOD) and IκBα in serum in patients with BPD. Increase of inflammatory factors (NFκB, iNOS, COX2, Keap1, NQO1) in peripheral blood mononuclear cells in those patients (P<0.05). |