Moos, 2000 (1313. Moos V, Rudwaleit M, Herzog V, Hohlig K, Sieper J, Muller B. Association of genotypes affecting the expression of interleukin-1beta or interleukin-1 receptor antagonist with osteoarthritis. Arthritis Rheum 2000; 43: 2417–2422, doi: 10.1002/1529-0131(200011)43:11<2417::AID-ANR7>3.0.CO;2-R. https://doi.org/10.1002/1529-0131(200011...
) |
HB |
Caucasian |
Knee/Hip |
36 |
166 |
18 |
74 |
1 |
0 |
0.005 |
7 |
Romero, 2002 (1717. Oregon-Romero E, Munoz-Valle JF, Martin-Marquez BT. -308 tumor necrosis factor-alpha promoter polymorphism in patients with rheumatoid arthritis and osteoarthritis in the west of Mexico: preliminary results. Rev Vaccimonitor (Vacunologiay Temasafines) 2002; 11: 52–58.) |
HB |
Caucasian |
Knee |
28 |
28 |
3 |
0 |
0 |
0 |
N/A |
7 |
Sezgin, 2008 (1111. Sezgin M, Barlas IO, Ankarali HC, Altintas ZM, Turkmen E, Gokdogan T, et al. Tumour necrosis factor alpha -308G/A gene polymorphism: lack of association with knee osteoarthritis in a Turkish population. Clin Exp Rheumatol 2008; 26: 763–768.) |
HB |
Caucasian |
Knee |
121 |
72 |
26 |
12 |
4 |
0 |
0.481 |
6 |
Han, 2012 (1414. Han L, Song JH, Yoon JH, Park YG, Lee SW, Choi YJ, et al. TNF-alpha and TNF-beta polymorphisms are associated with susceptibility to osteoarthritis in a Korean population. Korean J Pathol 2012; 6: 30–37, doi: 10.4132/KoreanJPathol.2012.46.1.30. https://doi.org/10.4132/KoreanJPathol.20...
) |
PB |
Asian |
Knee |
79 |
258 |
188 |
33 |
34 |
0 |
0.305 |
6 |
Valle, 2012 (1818. Valle AM, Shang Q, Lu FH. The association between tumor necrosis factor-alpha -308G/A gene polymorphism and the risk of OA. Chin Clini Rehab 2012; 65: 66–68.) |
PB |
Caucasian |
Knee |
44 |
93 |
6 |
7 |
0 |
0 |
0.717 |
5 |
Ji, 2013 (1919. Ji B, Shi J, Cheng X, Zhou J, Zhou Q, Cao C, et al. Association analysis of two candidate polymorphisms in the tumour necrosis factor-alpha gene with osteoarthritis in a Chinese population. Intl Orthop 2013; 37: 2061–2063, doi: 10.1007/s00264-013-1931-4. https://doi.org/10.1007/s00264-013-1931-...
) |
PB |
Asian |
Knee |
143 |
253 |
50 |
50 |
7 |
2 |
0.782 |
6 |
Cheng, 2013 (2020. Cheng X, Cao C, Ji B. Association of tumor necrosis factor-alpha-308 polymorphism with osteoarthritis in a Chinese population. Chinese Journal of Orthopaedic Trauma 2013; 15: 607–609.) |
PB |
Asian |
Knee |
143 |
253 |
50 |
49 |
7 |
3 |
0.716 |
7 |
Hamalainen, 2014 (1515. Hamalainen S, Solovieva S, Vehmas T, Leino-Arjas P, Hirvonen A. Variations in the TNFalpha gene and their interactions with the IL4R and IL10 genes in relation to hand osteoarthritis. BMC Musculoskelet Disord 2014; 15: 311, doi: 10.1186/1471-2474-15-311. https://doi.org/10.1186/1471-2474-15-311...
) |
PB |
Caucasian |
Hand |
231 |
578 |
82 |
173 |
7 |
13 |
0.989 |
8 |
Abdel, 2017 (1616. Abdel Galil SM, Ezzeldin N, Fawzy F, El-Boshy M. The single-nucleotide polymorphism (SNP) of tumor necrosis factor alpha -308G/A gene is associated with early-onset primary knee osteoarthritis in an Egyptian female population. Clin Rheumatol 2017; 36: 2525–2530, doi: 10.1007/s10067-017-3727-1. https://doi.org/10.1007/s10067-017-3727-...
) |
PB |
Caucasian |
Knee |
180 |
115 |
25 |
82 |
5 |
13 |
0.749 |
7 |
This study |
HB |
Asian |
Knee |
120 |
142 |
96 |
140 |
33 |
19 |
0.043 |
6 |