Epigenetic modification
|
|
|
Promoter hypermethylation |
lung, head and neck squamous cell carcinomas, renal cell, bladder, prostate, melanomas, colorectal, clear cell sarcoma of the kidney |
2626. Arab K, Park YJ, Lindroth AM, Schäfer A, Oakes C, Weichenhan D, et al. Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A. Mol Cell 2014; 55: 604–614, doi: 10.1016/j.molcel.2014.06.031. https://doi.org/10.1016/j.molcel.2014.06...
,6363. Smith LT, Lin M, Brena RM, Lang JC, Schuller DE, Otterson GA, et al. Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer. Proc Natl Acad Sci USA 2006; 103: 982–987, doi: 10.1073/pnas.0510171102. https://doi.org/10.1073/pnas.0510171102...
,6868. Dai Y, Duan H, Duan C, Zhou R, He Y, Tu Q, et al. Down-regulation of TCF21 by hypermethylation induces cell proliferation, migration and invasion in colorectal cancer. Biochem Biophys Res Commun 2016; 469: 430–436, doi: 10.1016/j.bbrc.2015.09.109. https://doi.org/10.1016/j.bbrc.2015.09.1...
69. Lu W, Yang C, Du P, Zhang JL, Zhang JC. Expression tendency and prognostic value of TCF21 in hepatocellular carcinoma. Artif Cells Nanomed Biotechnol 2019; 47: 1466–1470, doi: 10.1080/21691401.2019.1601102. https://doi.org/10.1080/21691401.2019.16...
,7070. Tessema M, Willink R, Do K, Yu YY, Yu W, Machida EO, et al. Promoter methylation of genes in and around the candidate lung cancer susceptibility locus 6q23-25. Cancer Res 2008; 68: 1707–1714, doi: 10.1158/0008-5472.CAN-07-6325. https://doi.org/10.1158/0008-5472.CAN-07...
,7474. Costa VL, Henrique R, Danielsen SA, Eknaes M, Patrício P, Morais A, et al. TCF21 and PCDH17 methylation: an innovative panel of biomarkers for a simultaneous detection of urological cancers. Epigenetics 2011; 6: 1120–1130, doi: 10.4161/epi.6.9.16376. https://doi.org/10.4161/epi.6.9.16376...
,7676. Gooskens SL, Gadd S, Auvil JMG, Gerhard DS, Khan J, Patidar R, et al. TCF21 hypermethylation in genetically quiescent clear cell sarcoma of the kidney. Oncotarget 2015; 6: 15828–15841, doi: 10.18632/oncotarget.4682. https://doi.org/10.18632/oncotarget.4682...
|
rs12190287 polymorphism |
breast, osteosarcoma |
8181. Gao X, Yang J, Wang M, Zhang J. TCF21 genetic polymorphisms and breast cancer risk in Chinese women. Oncotarget 2016; 7: 55757–55764, doi: 10.18632/oncotarget.9825. https://doi.org/10.18632/oncotarget.9825...
,8282. Jiang Z, Zhang W, Chen Z, Shao J, Chen L, Wang Z. Transcription factor 21 (TCF21) rs12190287 polymorphism is associated with osteosarcoma risk and outcomes in East Chinese population. Med Sci Monit 2017; 23: 3185–3191, doi: 10.12659/MSM.905595. https://doi.org/10.12659/MSM.905595...
|
Clinical biomarker
|
|
|
Prognostic factor |
lung adenocarcinoma, clear cell renal cell carcinoma, adult ACTs, metastatic melanoma, colorectal, esophageal squamous cell carcinoma |
1818. Arab K, Smith LT, Gast A, Weichenhan D, Huang JPH, Claus R, et al. Epigenetic deregulation of TCF21 inhibits metastasis suppressor KISS1 in metastatic melanoma. Carcinogenesis 2011; 32: 1467–1473, doi: 10.1093/carcin/bgr138. https://doi.org/10.1093/carcin/bgr138...
,6666. Passaia BS, Dias MH, Kremer JL, Antonini SRR, de Almeida MQ, Fragoso MCBV, et al. TCF21/POD-1, a transcriptional regulator of SF-1/NR5A1, as a potential prognosis marker in adult and pediatric adrenocortical tumors. Front Endocrinol (Lausanne) 2018; 9: 38, doi: 10.3389/fendo.2018.00038. https://doi.org/10.3389/fendo.2018.00038...
,7070. Tessema M, Willink R, Do K, Yu YY, Yu W, Machida EO, et al. Promoter methylation of genes in and around the candidate lung cancer susceptibility locus 6q23-25. Cancer Res 2008; 68: 1707–1714, doi: 10.1158/0008-5472.CAN-07-6325. https://doi.org/10.1158/0008-5472.CAN-07...
,7575. Ye YW, Jiang ZM, Li WH, Li ZS, Han YH, Sun L, et al. Down-regulation of TCF21 is associated with poor survival in clear cell renal cell carcinoma. Neoplasma 2012; 59: 599–605, doi: 10.4149/neo_2012_076. https://doi.org/10.4149/neo_2012_076...
,8989. Dai Y, Duan H, Duan C, Zhu H, Zhou R, Pei H, et al. TCF21 functions as a tumor suppressor in colorectal cancer through inactivation of PI3K/AKT signaling. Onco Targets Ther 2017; 10: 1603–1611, doi: 10.2147/OTT.S118151. https://doi.org/10.2147/OTT.S118151...
,9090. Chen Y, Zhang C, Chen J, Zhang B, Zhang H, Yang X, et al. Expression of transcription factor 21 (TCF21) and upregulation its level inhibits invasion and metastasis in esophageal squamous cell carcinoma. Med Sci Monit 2018 24: 4128–4136, doi: 10.12659/MSM.909138. https://doi.org/10.12659/MSM.909138...
|
Diagnostic factor |
bladder, prostate, renal, pediatric ACTs |
6666. Passaia BS, Dias MH, Kremer JL, Antonini SRR, de Almeida MQ, Fragoso MCBV, et al. TCF21/POD-1, a transcriptional regulator of SF-1/NR5A1, as a potential prognosis marker in adult and pediatric adrenocortical tumors. Front Endocrinol (Lausanne) 2018; 9: 38, doi: 10.3389/fendo.2018.00038. https://doi.org/10.3389/fendo.2018.00038...
,7474. Costa VL, Henrique R, Danielsen SA, Eknaes M, Patrício P, Morais A, et al. TCF21 and PCDH17 methylation: an innovative panel of biomarkers for a simultaneous detection of urological cancers. Epigenetics 2011; 6: 1120–1130, doi: 10.4161/epi.6.9.16376. https://doi.org/10.4161/epi.6.9.16376...
|
Tumor mass size |
breast |
7878. Wang J, Gao X, Wang M, Zhang J. Clinicopathological significance and biological role of TCF21 mRNA in breast cancer. Tumor Biol 2015; 36: 8679–8683, doi: 10.1007/s13277-015-3476-1. https://doi.org/10.1007/s13277-015-3476-...
|
Lymphoid metastases |
breast, colorectal |
7878. Wang J, Gao X, Wang M, Zhang J. Clinicopathological significance and biological role of TCF21 mRNA in breast cancer. Tumor Biol 2015; 36: 8679–8683, doi: 10.1007/s13277-015-3476-1. https://doi.org/10.1007/s13277-015-3476-...
|
Biological effect
|
|
|
Reduction of tumor growth |
gastric |
6767. Yang Z, Li DM, Xie Q, Dai DQ. Protein expression and promoter methylation of the candidate biomarker TCF21 in gastric cancer. J Cancer Res Clin Oncol 2014; 141: 211–220, doi: 10.1007/s00432-014-1809-x. https://doi.org/10.1007/s00432-014-1809-...
|
Cell death by apoptosis |
NSCLC |
7272. Chen B, Zeng C, Ye Y, Wu D, Mu Z, Liu J, et al. Promoter methylation of TCF21 may repress autophagy in the progression of lung cancer. J Cell Commu Signal 2018; 12: 423–432, doi: 10.1007/s12079-017-0418-2. https://doi.org/10.1007/s12079-017-0418-...
|
Decreased cell viability |
NSCLC |
7272. Chen B, Zeng C, Ye Y, Wu D, Mu Z, Liu J, et al. Promoter methylation of TCF21 may repress autophagy in the progression of lung cancer. J Cell Commu Signal 2018; 12: 423–432, doi: 10.1007/s12079-017-0418-2. https://doi.org/10.1007/s12079-017-0418-...
|
Apoptosis reduction |
breast |
7979. Li PW, Wang HY, Xu LL. Effect of TCF21 on proliferation, migration and vascular production of breast cancer cells [in Chinese]. Zhonghua Bing Li Xue Za Zhi 2019; 48: 307–311, doi: 10.3760/cma.j.issn.0529-5807.2019.04.009. https://doi.org/10.3760/cma.j.issn.0529-...
|
Inhibition of cell invasion |
NSCLC, breast, colorectal, gastric, esophageal squamous cell carcinoma |
6767. Yang Z, Li DM, Xie Q, Dai DQ. Protein expression and promoter methylation of the candidate biomarker TCF21 in gastric cancer. J Cancer Res Clin Oncol 2014; 141: 211–220, doi: 10.1007/s00432-014-1809-x. https://doi.org/10.1007/s00432-014-1809-...
,6868. Dai Y, Duan H, Duan C, Zhou R, He Y, Tu Q, et al. Down-regulation of TCF21 by hypermethylation induces cell proliferation, migration and invasion in colorectal cancer. Biochem Biophys Res Commun 2016; 469: 430–436, doi: 10.1016/j.bbrc.2015.09.109. https://doi.org/10.1016/j.bbrc.2015.09.1...
,7272. Chen B, Zeng C, Ye Y, Wu D, Mu Z, Liu J, et al. Promoter methylation of TCF21 may repress autophagy in the progression of lung cancer. J Cell Commu Signal 2018; 12: 423–432, doi: 10.1007/s12079-017-0418-2. https://doi.org/10.1007/s12079-017-0418-...
,7979. Li PW, Wang HY, Xu LL. Effect of TCF21 on proliferation, migration and vascular production of breast cancer cells [in Chinese]. Zhonghua Bing Li Xue Za Zhi 2019; 48: 307–311, doi: 10.3760/cma.j.issn.0529-5807.2019.04.009. https://doi.org/10.3760/cma.j.issn.0529-...
,8989. Dai Y, Duan H, Duan C, Zhu H, Zhou R, Pei H, et al. TCF21 functions as a tumor suppressor in colorectal cancer through inactivation of PI3K/AKT signaling. Onco Targets Ther 2017; 10: 1603–1611, doi: 10.2147/OTT.S118151. https://doi.org/10.2147/OTT.S118151...
,9090. Chen Y, Zhang C, Chen J, Zhang B, Zhang H, Yang X, et al. Expression of transcription factor 21 (TCF21) and upregulation its level inhibits invasion and metastasis in esophageal squamous cell carcinoma. Med Sci Monit 2018 24: 4128–4136, doi: 10.12659/MSM.909138. https://doi.org/10.12659/MSM.909138...
|
Inhibition of cell migration |
renal, breast, melanomas, colorectal, gastric, esophageal squamous cell carcinoma |
1818. Arab K, Smith LT, Gast A, Weichenhan D, Huang JPH, Claus R, et al. Epigenetic deregulation of TCF21 inhibits metastasis suppressor KISS1 in metastatic melanoma. Carcinogenesis 2011; 32: 1467–1473, doi: 10.1093/carcin/bgr138. https://doi.org/10.1093/carcin/bgr138...
,6464. Gooskens SL, Klasson TD, Gremmels H, Logister I, Pieters R, Perlman EJ, et al. TCF21 hypermethylation regulates renal tumor cell clonogenic proliferation and migration. Mol Oncol 2018; 12: 166–179, doi: 10.1002/1878-0261.12149. https://doi.org/10.1002/1878-0261.12149...
,6767. Yang Z, Li DM, Xie Q, Dai DQ. Protein expression and promoter methylation of the candidate biomarker TCF21 in gastric cancer. J Cancer Res Clin Oncol 2014; 141: 211–220, doi: 10.1007/s00432-014-1809-x. https://doi.org/10.1007/s00432-014-1809-...
,6868. Dai Y, Duan H, Duan C, Zhou R, He Y, Tu Q, et al. Down-regulation of TCF21 by hypermethylation induces cell proliferation, migration and invasion in colorectal cancer. Biochem Biophys Res Commun 2016; 469: 430–436, doi: 10.1016/j.bbrc.2015.09.109. https://doi.org/10.1016/j.bbrc.2015.09.1...
,7979. Li PW, Wang HY, Xu LL. Effect of TCF21 on proliferation, migration and vascular production of breast cancer cells [in Chinese]. Zhonghua Bing Li Xue Za Zhi 2019; 48: 307–311, doi: 10.3760/cma.j.issn.0529-5807.2019.04.009. https://doi.org/10.3760/cma.j.issn.0529-...
,8989. Dai Y, Duan H, Duan C, Zhu H, Zhou R, Pei H, et al. TCF21 functions as a tumor suppressor in colorectal cancer through inactivation of PI3K/AKT signaling. Onco Targets Ther 2017; 10: 1603–1611, doi: 10.2147/OTT.S118151. https://doi.org/10.2147/OTT.S118151...
,9090. Chen Y, Zhang C, Chen J, Zhang B, Zhang H, Yang X, et al. Expression of transcription factor 21 (TCF21) and upregulation its level inhibits invasion and metastasis in esophageal squamous cell carcinoma. Med Sci Monit 2018 24: 4128–4136, doi: 10.12659/MSM.909138. https://doi.org/10.12659/MSM.909138...
|
Inhibition of cell proliferation |
breast, colorectal, gastric, esophageal squamous cell carcinoma |
6767. Yang Z, Li DM, Xie Q, Dai DQ. Protein expression and promoter methylation of the candidate biomarker TCF21 in gastric cancer. J Cancer Res Clin Oncol 2014; 141: 211–220, doi: 10.1007/s00432-014-1809-x. https://doi.org/10.1007/s00432-014-1809-...
,6868. Dai Y, Duan H, Duan C, Zhou R, He Y, Tu Q, et al. Down-regulation of TCF21 by hypermethylation induces cell proliferation, migration and invasion in colorectal cancer. Biochem Biophys Res Commun 2016; 469: 430–436, doi: 10.1016/j.bbrc.2015.09.109. https://doi.org/10.1016/j.bbrc.2015.09.1...
,7979. Li PW, Wang HY, Xu LL. Effect of TCF21 on proliferation, migration and vascular production of breast cancer cells [in Chinese]. Zhonghua Bing Li Xue Za Zhi 2019; 48: 307–311, doi: 10.3760/cma.j.issn.0529-5807.2019.04.009. https://doi.org/10.3760/cma.j.issn.0529-...
,8989. Dai Y, Duan H, Duan C, Zhu H, Zhou R, Pei H, et al. TCF21 functions as a tumor suppressor in colorectal cancer through inactivation of PI3K/AKT signaling. Onco Targets Ther 2017; 10: 1603–1611, doi: 10.2147/OTT.S118151. https://doi.org/10.2147/OTT.S118151...
,9090. Chen Y, Zhang C, Chen J, Zhang B, Zhang H, Yang X, et al. Expression of transcription factor 21 (TCF21) and upregulation its level inhibits invasion and metastasis in esophageal squamous cell carcinoma. Med Sci Monit 2018 24: 4128–4136, doi: 10.12659/MSM.909138. https://doi.org/10.12659/MSM.909138...
|
Angiogenesis inhibition |
breast |
7979. Li PW, Wang HY, Xu LL. Effect of TCF21 on proliferation, migration and vascular production of breast cancer cells [in Chinese]. Zhonghua Bing Li Xue Za Zhi 2019; 48: 307–311, doi: 10.3760/cma.j.issn.0529-5807.2019.04.009. https://doi.org/10.3760/cma.j.issn.0529-...
|