TLR3
|
rs3775291 [A/G] |
Chr 4 |
Transition Substitution |
AA genotype promotes increased CHIKV infection susceptibility. |
(1313. Bucardo F, Reyes Y, Morales M, Briceão R, González F, Lundkvist Å, et al. Association of genetic polymorphisms in DC-SIGN, toll-like receptor 3, and tumor necrosis factor α genes and the Lewis-negative phenotype with Chikungunya infection and disease in Nicaragua. J Infect Dis 2021; 223: 278-286, doi: 10.1093/infdis/jiaa364. https://doi.org/10.1093/infdis/jiaa364...
) |
|
rs3775290 [T/C] |
|
Transition Substitution |
TT genotype increases the risk of arboviruses coinfection. Increases the risk of Chikungunya infection. |
(6868. Sengupta S, Mukherjee S, Bhattacharya N, Tripathi A. Differential genotypic signatures of Toll-like receptor polymorphisms among dengue-chikungunya mono-and co-infected Eastern Indian patients. Eur J Clin Microbiol Infect Dis 2021; 1-13, doi: 10.1007/s10096-020-04125-x. https://doi.org/10.1007/s10096-020-04125...
) |
TLR7
|
rs3853839 [C/G] |
Chr.X |
Transversion Substitution |
GC genotype is associated with increased risk of CHIKV infection. Increases the risk of fever and rash. |
(1111. Dutta SK, Tripathi A. Association of toll-like receptor polymorphisms with susceptibility to Chikungunya virus infection. Virology 2017; 511: 207-213, doi: 10.1016/j.virol.2017.08.009. https://doi.org/10.1016/j.virol.2017.08....
,6868. Sengupta S, Mukherjee S, Bhattacharya N, Tripathi A. Differential genotypic signatures of Toll-like receptor polymorphisms among dengue-chikungunya mono-and co-infected Eastern Indian patients. Eur J Clin Microbiol Infect Dis 2021; 1-13, doi: 10.1007/s10096-020-04125-x. https://doi.org/10.1007/s10096-020-04125...
) |
|
rs179010 [T/C] |
|
Transversion Substitution |
Increases the risk of fever and rash. |
(1111. Dutta SK, Tripathi A. Association of toll-like receptor polymorphisms with susceptibility to Chikungunya virus infection. Virology 2017; 511: 207-213, doi: 10.1016/j.virol.2017.08.009. https://doi.org/10.1016/j.virol.2017.08....
) |
|
rs574880 [G/T] |
|
|
|
(1111. Dutta SK, Tripathi A. Association of toll-like receptor polymorphisms with susceptibility to Chikungunya virus infection. Virology 2017; 511: 207-213, doi: 10.1016/j.virol.2017.08.009. https://doi.org/10.1016/j.virol.2017.08....
) |
TLR8
|
rs3764880 [A/G] |
Chr.X |
Transversion Substitution |
AG genotype is associated with susceptibility to CHIKV infection. |
(6868. Sengupta S, Mukherjee S, Bhattacharya N, Tripathi A. Differential genotypic signatures of Toll-like receptor polymorphisms among dengue-chikungunya mono-and co-infected Eastern Indian patients. Eur J Clin Microbiol Infect Dis 2021; 1-13, doi: 10.1007/s10096-020-04125-x. https://doi.org/10.1007/s10096-020-04125...
) |
|
rs3764879 [G/C] |
|
|
Association with increased risk of CHIKV infection. |
(1111. Dutta SK, Tripathi A. Association of toll-like receptor polymorphisms with susceptibility to Chikungunya virus infection. Virology 2017; 511: 207-213, doi: 10.1016/j.virol.2017.08.009. https://doi.org/10.1016/j.virol.2017.08....
,6868. Sengupta S, Mukherjee S, Bhattacharya N, Tripathi A. Differential genotypic signatures of Toll-like receptor polymorphisms among dengue-chikungunya mono-and co-infected Eastern Indian patients. Eur J Clin Microbiol Infect Dis 2021; 1-13, doi: 10.1007/s10096-020-04125-x. https://doi.org/10.1007/s10096-020-04125...
) |
HLA II
|
DQB1*03: 03/ DRB1*11 |
Chr.6 |
Insertion/Deletion (Indels) |
Protection against CHIKV infection. |
(7777. Chaaithanya IK, Muruganandam N, Anwesh M, Rajesh R, Ghosal SR, Kartick C, et al. HLA class II allele polymorphism in an outbreak of Chikungunya fever in middle Andaman, India. Immunology 2013; 140: 202-210, doi: 10.1111/imm.12128. https://doi.org/10.1111/imm.12128...
,7878. Thanapati S, Hande A, Das R, Gurav Y, Tripathy AS. Association of human leukocyte antigen class II allele and haplotypes in Chikungunya viral infection in a western Indian population. Trans R Soc Trop Med Hyg 2014; 108: 277-282, doi: 10.1093/trstmh/tru030. https://doi.org/10.1093/trstmh/tru030...
) |
-DQB1 -DRB1
|
DQB1*03DRB1*4 |
|
|
Susceptibility to CHIKV infection. |
(7878. Thanapati S, Hande A, Das R, Gurav Y, Tripathy AS. Association of human leukocyte antigen class II allele and haplotypes in Chikungunya viral infection in a western Indian population. Trans R Soc Trop Med Hyg 2014; 108: 277-282, doi: 10.1093/trstmh/tru030. https://doi.org/10.1093/trstmh/tru030...
) |
TNF
|
rs1800629 [A/G] |
Chr.6 |
Transition Substitution |
Associated with decreased persistent joint pain in patients with Chikungunya disease. |
(1313. Bucardo F, Reyes Y, Morales M, Briceão R, González F, Lundkvist Å, et al. Association of genetic polymorphisms in DC-SIGN, toll-like receptor 3, and tumor necrosis factor α genes and the Lewis-negative phenotype with Chikungunya infection and disease in Nicaragua. J Infect Dis 2021; 223: 278-286, doi: 10.1093/infdis/jiaa364. https://doi.org/10.1093/infdis/jiaa364...
) |
IL1RN
|
*1/* |
Chr.2 |
Tandem Repeat |
Association with increased risk of CHIKV infection. |
(8282. Tripathy AS, Ganu MA, Sonam L, Alagarasu K, Walimbe AM, Thanapati S, et al. Association of IL1RN VNTR polymorphism with Chikungunya infection: a study from Western India. J Med Virol 2019; 91: 1901-1908, doi: 10.1002/jmv.25546. https://doi.org/10.1002/jmv.25546...
) |
|
*2 |
|
|
Protection against chronic Chikungunya. |
(8282. Tripathy AS, Ganu MA, Sonam L, Alagarasu K, Walimbe AM, Thanapati S, et al. Association of IL1RN VNTR polymorphism with Chikungunya infection: a study from Western India. J Med Virol 2019; 91: 1901-1908, doi: 10.1002/jmv.25546. https://doi.org/10.1002/jmv.25546...
) |
CD209
|
rs4804803 [A /G] |
Chr.19 |
Transition Substitution |
Promotes susceptibility to CHIKV infection. |
(22. Chaaithanya IK, Muruganandam N, Surya P, Anwesh M, Alagarasu K, Vijayachari P. Association of oligoadenylate synthetase gene cluster and DC-SIGN (CD209) gene polymorphisms with clinical symptoms in Chikungunya virus infection. DNA Cell Biol 2016; 35: 44-50, doi: 10.1089/dna.2015.2819. https://doi.org/10.1089/dna.2015.2819...
,1313. Bucardo F, Reyes Y, Morales M, Briceão R, González F, Lundkvist Å, et al. Association of genetic polymorphisms in DC-SIGN, toll-like receptor 3, and tumor necrosis factor α genes and the Lewis-negative phenotype with Chikungunya infection and disease in Nicaragua. J Infect Dis 2021; 223: 278-286, doi: 10.1093/infdis/jiaa364. https://doi.org/10.1093/infdis/jiaa364...
) |
OAS3
|
rs2285932 [C/T] |
Chr.12 |
Transition Substitution |
Associated with a reduced risk of chills. |
(22. Chaaithanya IK, Muruganandam N, Surya P, Anwesh M, Alagarasu K, Vijayachari P. Association of oligoadenylate synthetase gene cluster and DC-SIGN (CD209) gene polymorphisms with clinical symptoms in Chikungunya virus infection. DNA Cell Biol 2016; 35: 44-50, doi: 10.1089/dna.2015.2819. https://doi.org/10.1089/dna.2015.2819...
) |
OAS1
|
rs1131434 [G/G] |
|
Transition Substitution |
Associated with reduced risk of edema. |
(22. Chaaithanya IK, Muruganandam N, Surya P, Anwesh M, Alagarasu K, Vijayachari P. Association of oligoadenylate synthetase gene cluster and DC-SIGN (CD209) gene polymorphisms with clinical symptoms in Chikungunya virus infection. DNA Cell Biol 2016; 35: 44-50, doi: 10.1089/dna.2015.2819. https://doi.org/10.1089/dna.2015.2819...
) |
OAS2
|
rs1732778 [G/A]rs15895 [G/A] |
|
Transition Substitution |
Associations with symptoms such as edema, fever, chills, and reduced conjunctival redness. |
(22. Chaaithanya IK, Muruganandam N, Surya P, Anwesh M, Alagarasu K, Vijayachari P. Association of oligoadenylate synthetase gene cluster and DC-SIGN (CD209) gene polymorphisms with clinical symptoms in Chikungunya virus infection. DNA Cell Biol 2016; 35: 44-50, doi: 10.1089/dna.2015.2819. https://doi.org/10.1089/dna.2015.2819...
) |
CRP
|
rs3091244 [T/C] |
Chr.1 |
Transition Substitution |
CT genotype confers protection against CHIKV infection. Patients with CC genotype present higher viral load for CHIKV. |
(9090. Sengupta S, Bhattacharya N, Tripathi A. Association of C-reactive protein polymorphisms with serum-CRP concentration and viral load among dengue-chikungunya mono/co-infected patients. Antiviral Res 2022; 197: 105225, doi: 10.1016/j.antiviral.2021.105225. https://doi.org/10.1016/j.antiviral.2021...
) |
|
rs3093059 [T/C]rs3091244 [T/C] |
|
|
Genotypes CT and TT are associated with protection against arthralgia produced by CHIKV. |
(8787. Sengupta S, Bhattacharya N, Tripathi A. Increased CRP, anti-CCP antibody, IL-2R, COMP levels in prognosis of post-chikungunya chronic arthritis and protective role of their specific genotypes against arthritic manifestation. Virus Res 2022; 23: 198998, doi: 10.1016/j.virusres.2022.198998. https://doi.org/10.1016/j.virusres.2022....
) |