FXTAS |
FMR1; FMR4
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Sequestration of RNA binding protein; antisense transcript |
Tassone et al. 2004 5858. Tassone F, Iwahashi C, Hagerman PJ. FMR1 RNA within the intranuclear inclusions of fragile X-associated tremor/ataxia syndrome (FXTAS). RNA Biol 2004; 1: 103–105, doi: 10.4161/rna.1.2.1035. https://doi.org/10.4161/rna.1.2.1035...
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DM1 |
DMPK
|
Sequestration of RNA binding protein; antisense transcript |
Rau et al. 2011 6666. Rau F, Freyermuth F, Fugier C, Villemin J. P, Fischer M. C, Jost, B, et al. Misregulation of miR-1 processing is associated with heart defects in myotonic dystrophy. Nature Struct Molec Biol 2011, 18, 840–845, doi: 10.1038/nsmb.2067. https://doi.org/10.1038/nsmb.2067...
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SCA1 |
ATXN1
|
Altered miRNA pathway |
Galka-Marciniak et al. 2012 5656. Galka-Marciniak P, Urbanek MO, Krzyzosiak WJ. Triplet repeats in transcripts: structural insights into RNA toxicity. Biol Chem 2012; 393: 1299–1315, doi: 10.1515/hsz-2012-0218. https://doi.org/10.1515/hsz-2012-0218...
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SCA3 |
ATXN3
|
An auxiliary toxic long CAG repeat RNA; altered miRNA pathway |
Galka-Marciniak et al. 2012 5656. Galka-Marciniak P, Urbanek MO, Krzyzosiak WJ. Triplet repeats in transcripts: structural insights into RNA toxicity. Biol Chem 2012; 393: 1299–1315, doi: 10.1515/hsz-2012-0218. https://doi.org/10.1515/hsz-2012-0218...
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SCA7 |
ATXN7
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Antisense transcript repress sense ataxin-7 |
Tan et al. 2014 6363. Tan JY, Vance KW, Varela MA, Sirey T, Watson LM, Curtis HJ, et al. Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7. Nat Struct Mol Biol 2014; 21: 955–961, doi: 10.1038/nsmb.2902. https://doi.org/10.1038/nsmb.2902...
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SCA8 |
ATXN8OS; ATXN8
|
Sequestration of RNA binding protein; antisense transcript |
Daughters et al. 2009 6161. Daughters RS, Tuttle DL, Gao W, Ikeda Y, Moseley ML, Ebner TJ, et al. RNA gain-of-function in spinocerebellar ataxia type 8. PLoS Genet 2009; 5: e1000600, doi: 10.1371/journal.pgen.1000600. https://doi.org/10.1371/journal.pgen.100...
; Moseley et al. 2006 6262. Moseley ML, Zu T, Ikeda Y, Gao W, Mosemiller AK, Daughters RS, et al. Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8. Nat Genet 2006; 38: 758–769, doi: 10.1038/ng1827. https://doi.org/10.1038/ng1827...
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HDL2 |
JPH3
|
Antisense transcript; polyQ toxicity |
Wojciechowska and Krzyzosiak, 2011 55. Wojciechowska M, Krzyzosiak WJ. Cellular toxicity of expanded RNA repeats: focus on RNA foci. Hum Mol Genet 2011; 20: 3811–3821, doi: 10.1093/hmg/ddr299. https://doi.org/10.1093/hmg/ddr299...
|
MTLE |
P2X7
|
Down-regulation by miR-22 |
Jimenez-Mateos et al. 2015 33. Jimenez-Mateos EM, Arribas-Blazquez M, Sanz-Rodriguez A, Concannon C, Olivos-Ore LA, Reschke CR, et al. microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus. Sci Rep 2015; 5: 17486, doi: 10.1038/srep17486. https://doi.org/10.1038/srep17486...
|
HD |
HTT
|
An auxiliary toxic long CAG repeat RNA; altered miRNA pathway |
Wojciechowska and Krzyzosiak, 2011 55. Wojciechowska M, Krzyzosiak WJ. Cellular toxicity of expanded RNA repeats: focus on RNA foci. Hum Mol Genet 2011; 20: 3811–3821, doi: 10.1093/hmg/ddr299. https://doi.org/10.1093/hmg/ddr299...
|
MTLE |
Genes involved with inflammation |
Up-regulation of miR-146a expression |
Aronica et al. 2010 3737. Aronica E, Fluiter K, Iyer A, Zurolo E, Vreijling J, van Vliet EA, et al. Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy. Euro J Neurosci 2010; 31: 1100–1107, doi: 10.1111/j.1460-9568.2010.07122.x. https://doi.org/10.1111/j.1460-9568.2010...
|
ALS |
SOD1 and others |
An artificial microRNA may extend survival and delays paralysis; Up regulation of miR-206. |
Stoica et al. 2016 7979. Stoica L, Todeasa SH, Toro Cabrera G, Salameh JS, ElMallah MK, Mueller C, et al. Adno associated virus delivered artificial microRNA extends survival and delays paralysis in an amyotrophic lateral sclerosis mouse model. Ann Neurol 2016; 79: 687–700, doi: 10.1002/ana.24618. https://doi.org/10.1002/ana.24618...
; Takahashi et al. 2015 8181. Takahashi I, Hama Y, Matsushima M, Hirotani M, Kano T, Hohzen H, et al. Identification of plasma microRNAs as a biomarker of sporadic amyotrophic lateral sclerosis. Mol Brain 2015; 8; 67, doi: 10.1186/s13041-015-0161-7. https://doi.org/10.1186/s13041-015-0161-...
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Cortical dysplasia |
Lis1
|
Dysregulation of miR-139-5p |
Huang et al. 2014 9090. Huang Y, Jiang J, Zheng G, Chen J, Lu H, Guo H, et al. miR-139-5p modulates cortical neuronal migration by targeting Lis1 in a rat model of focal cortical dysplasia. Int J Mol Med 2014; 33: 1407–1414, doi: 10.3892/ijmm.2014.1703. https://doi.org/10.3892/ijmm.2014.1703...
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Pain |
Inflammation, neural processing |
Dysregulation of miR-1, -16, and -206 |
Kusuda et al. 2011 8686. Kusuda R, Cadetti F, Ravanelli MI, Sousa TA, Zanon S, De Lucca FL, et al. Differential expression of microRNAs in mouse pain models. Mol Pain 2011; 7: 17, doi: 10.1186/1744-8069-7-17. https://doi.org/10.1186/1744-8069-7-17...
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