Westin1414 Hesser H, Gustafsson T, Lundén C, Henrikson O, Fattahi K, Johnsson E, et al. A randomized controlled trial of Internet-delivered cognitive behavior therapy and acceptance and commitment therapy in the treatmen of tinnitus. J Consult Clin Psychol. 2012;80:649–61.
|
2016 |
Germany |
RCT |
62 |
62 |
47.81 (12.26) |
47.51 (14.07) |
59.7 |
59.7 |
C |
D |
①②③④ |
Cima2323 Li J, Jin J, Xi S, Zhu Q, Chen Y,Huang M, et al. Clinical efficacy of cognitive behavioral therapy for chronic subjective tinnitus. Am J Otolaryngol. 2019;40:253–6.
|
2012 |
Britain |
RCT |
247 |
245 |
54.63 (12.02) |
53.74 (11.05) |
61 |
65 |
C |
D |
①② |
Li2424 Chung H-K, Tsai C-H, Lin Y-C, Chen J-M, Tsou Y-A, Wang C-Y, et al. Effectiveness of theta-burst repetitive transcranial magnetic stimulation for treating chronic tinnitus. Audiol Neurootol. 2012;17:112–20.
|
2019 |
China |
RCT |
50 |
50 |
42.66 (3.72) |
43.81 (4.12) |
56 |
62 |
C |
S |
① |
Hesser1515 Beukes EW, Andersson G, Allen PM, Manchaiah V, Baguley DM. Effectiveness of guided internet-based cognitive behavioral therapy vs face-to-face clinical care for treatment of tinnitus: a randomized clinical trial. JAMA Otolaryngol Head Neck Surg. 2018;144:1126–33.
|
2012 |
Germany |
RCT |
32/35 |
32 |
48.8 (13.4)/50.1 (16.4) |
48.4 (14.2) |
43.8/42.9 |
43.4 |
C |
A/D |
①③④ |
Beukes1616 LandgrebeM, Hajak G, Wolf S, Padberg F,Klupp PFallgatter AJ, et al. 1-Hz rTMS in the treatment of tinnitus: a sham-controlled, randomized multicenter trial. Brain Stimul. 2017;10:1112–20.
|
2018 |
Britain |
RCT |
46 |
46 |
50.65 (12.19) |
55.26 (11.62) |
63 |
57 |
C |
D |
①④ |
Chung2525 Hoekstra CE, Versnel H, Neggers SF, Niesten ME, van Zanten GA. Bilateral low-frequency repetitive transcranial magnetic stimulation of the auditory cortex in tinnitus patients is not effective: a randomised controlled trial. Audiol Neurootol. 2013;18:362–73.
|
2012 |
America |
RCT |
10 |
12 |
/ |
/ |
/ |
/ |
T |
P |
①② |
Landgrebe1717 Henry JA, Stewart BJ, Griest S, Kaelin C, Zaugg TL, Carlson K. Multisite randomized controlled trial to compare two methods of tinnitus intervention to two control conditions. Ear Hear. 2016;37:e346–59.
|
2017 |
Germany |
RCT |
71 |
75 |
48.1 (12.5) |
49.9(13.2) |
76 |
68 |
T |
P |
①② |
Hoekstra2626 Rossi S, De Capua A, Ulivelli M, Bartalini S, Falzarano V, Filippone G, et al. Effects of repetitive transcranial magnetic stimulation on chronic tinnitus: a randomised, crossover, double blind, placebo controlled study. J Neurol Neurosurg Psychiatry. 2007;78:857–63.
|
2013 |
NZ |
RCT |
26 |
24 |
50 (12) |
55 (12) |
100 |
63 |
T |
P |
①②⑥ |
Rossi2727 Pal N, Maire R, Stephan MA, Herrmann FR, Benninger DH. Transcranial direct current stimulation for the treatment of chronic tinnitus: a randomized controlled study. Brain Stimul. 2015;8:1101–7.
|
2007 |
Italy |
RCT |
22 |
20 |
/ |
/ |
/ |
/ |
T |
P |
①②⑥ |
Pal2828 Lee SK, Chung H, Chung JH, Yeo SG, Park MS, Byun JY. Effectiveness of transcutaneous electrical stimulation for chronic tinnitus. Acta Otolaryngol. 2014;134:159–67.
|
2015 |
NZ |
RCT |
21 |
21 |
48.0 (9.9) |
51.6 (12.2) |
57.1 |
57.1 |
E |
P |
①⑤⑥ |
Forogh2121 Malinvaud D, Londero A, Niarra R, Peignard P, Warusfel O, Viaud-Delmon I, et al. Auditory and visual 3D virtual reality therapy as a new treatment for chronic subjective tinnitus: results of a randomized controlled trial. Hear Res. 2016;333:127–35.
|
2019 |
Ireland |
RCT |
11 |
11 |
49.81 (4.14) |
46.63 (5.26) |
36.4 |
36.4 |
E |
P |
①⑤⑥ |
Tutar2020 Forogh B, Mirshaki Z, Raissi GR, Shirazi A, Mansoori K, Ahadi T. Repeated sessions of transcranial direct current stimulation for treatment of chronic subjective tinnitus: a pilot randomized controlled trial. Neurol Sci. 2016;37:253–9.
|
2020 |
Turkey |
RCT |
20 |
20 |
/ |
/ |
/ |
/ |
E |
P |
① |
Lee2929 Chen J, Zhong P Meng Z, Pan F,Qi L, He T, et al. Investigation on chronic tinnitus efficacy of combination of non-repetitive preferred music and educationa counseling: a preliminary study. Eur Arch Otorhinolaryngol. 2021;278:2745–52.
|
2014 |
Korea |
RCT |
45 |
20 |
46.6 (13.9) |
46.6 (13.9) |
42.2 |
28 |
E |
P |
①⑤⑥ |
Henry1818 Westin VZ, Schulin M, Hesse H, Karlsson M, Noe RZ, Olofsson U, et al. Acceptance and commitment therapy versus tinnitus retraining therapy in the treatment of tinnitus: a randomised controlled trial. Behav Res Ther. 2011;49:737–47.
|
2016 |
America |
RCT |
42/34 |
39/33 |
62.4 (9.8)/60.1 (10.1) |
62.7 (10.6)/61.2 (8.8) |
95.2/97.1 |
100/97 |
R/D |
S/P |
① |
Westin1919 Tutar B, Atar S, Berkiten G, Üstün O, Kumral TL, Uyar Y. The effect of transcutaneous electrical nerve stimulation (TENS) on chronic subjective tinnitus. Am J Otolaryngol. 2020;41:102326.
|
2011 |
Sweden |
RCT |
20 |
20/22 |
53.5 (12.84) |
48.9 (14.5)/49.5 (11.86) |
64 |
40/36 |
R |
A/AP |
①③④ |
Chen3030 Anders M, Dvorakova J, Rathova L, Havrankova P, Pelcova P, Vaneckova M, et al. Efficacy of repetitive transcranial magnetic stimulation for the treatment of refractory chronic tinnitus: a randomized, placebo controlled study. Neuro Endocrinol Lett. 2010;31:238–49.
|
2012 |
China |
RCT |
30 |
30 |
37 (20.50) |
45 (18.25) |
36.7 |
50 |
S |
D |
①⑤ |
Malinvaud2222 Cima RF, Maes IH, JooreMA, Scheyen DJWM, El Refaie A, Baguley DM, et al. Specialised treatment based on cognitive behaviour therapy versus usual care for tinnitus: a randomised controlled trial. Lancet. 2012;379:1951–9.
|
2016 |
France |
RCT |
55 |
61 |
49.14(12.11) |
52.2 (12.64) |
65.45 |
80.33 |
C |
V |
①③⑤ |
McKenna3333 Stein A, Wunderlich R, Lau P Engell A, Wollbrink A, Shaykevich A, et al. Clinical trial on tonal tinnitus with tailor-made notched music training. BMC Neurol. 2016;16:38.
|
2017 |
America |
RCT |
45 |
44 |
53 (14) |
47 (17) |
75.5 |
36.4 |
C |
D |
①③⑤ |
Weise3535 Yakunina N, Nam EC. Direct and transcutaneous vagus nerve stimulation for treatment of tinnitus: a scoping review. Front Neurosci. 2021;15:680590.
|
2008 |
Germany |
RCT |
52 |
59 |
49.46 (11.83) |
52.93 (11.92) |
55.8 |
55.9 |
C |
P |
①⑤⑥ |
Argstatter3232 McKenna L, Marks EM, Hallsworth CA, Schaette R. Mindfulness-based cognitive therapy as a treatment for chronic tinnitus: a randomized controlled trial. Psychother Psychosom. 2017;86:351–61.
|
2015 |
Germany |
RCT |
146 |
144 |
45.1 (12.4) |
53.2 (12.0) |
71.2 |
65.3 |
S |
D |
① |
Stein3434 Weise C, Heinecke K, Rief W. Biofeedback-based behavioral treatment for chronic tinnitus: results of a randomized controlled trial. J Consult Clin Psychol. 2008;76:1046–57.
|
2016 |
Germany |
RCT |
50 |
50 |
47.68 (9.94) |
47.13 (11.70) |
66 |
68 |
S |
P |
①⑤ |
Anders3131 Argstatter H, Grapp M, Hutter E, Plinkert PK, Bolay HV. The effectiveness of neuro-music therapy according to the Heidelberg model compared to a single session of educational counseling as treatment for tinnitus: a controlled trial. J Psychosom Res. 2015;78:285–92.
|
2010 |
Czech Republic |
RCT |
20 |
22 |
27-66 |
20-69 |
/ |
/ |
S |
D |
|