Hashimoto's thyroiditis - an independent risk factor for papillary carcinoma

The aim of our study was to determine the prevalence of thyroid carcinoma and Hashimoto's thyroiditis coexistence in histopathologic material of thyroidectomized patients.

Methods:

In a retrospective study, the clinicohistopathologic data of 2117 patients (1738 females/379 males), who underwent total or partial thyroidectomy for thyroid gland disorder at a single institution from the 1st of January 2005 to the 31st of December 2014 were analyzed.

Results:

Thyroid carcinoma was detected in 318 cases (15%) and microcarcinoma (thyroid cancer ≤10 mm in diameter) was found in permanent sections in 169 cases (8%). Hashimoto's thyroiditis was detected in 318 (15%) patients. Hashimoto's thyroiditis was significantly more often associated with thyroid carcinoma and microcarcinoma compare to benign condition (p = 0.048, p = 0.00014, respectively). Coexistence of Hashimoto's thyroiditis and thyroid carcinoma/thyroid microcarcinoma did not affect tumor size (p = 0.251, p = 0.098, respectively), or tumor multifocality (p = 0.831, p = 0.957, respectively). Bilateral thyroid microcarcinoma was significantly more often detected when Hashimoto's thyroiditis was also diagnosed (p = 0.041), but presence of Hashimoto's thyroiditis did not affect bilateral occurrence of thyroid carcinoma (p = 0.731).

Conclusion:

Hashimoto's thyroiditis is associated with significantly increased risk of developing thyroid carcinoma, especially thyroid microcarcinoma.

KEYWORDS
Thyroid cancer; Microcarcinoma; Hashimoto's thyroiditis

	Benign	Thyroid carcinoma	Microcarcinoma	p-value
N	1630 (77%)	318 (15%)	169 (8%)	NA
Male	277 (17%)	60 (19%)	42 (24%)	0.122
Female	1348 (83%)	261 (81%)	129 (76%)	0.122
Age	47.2 ± 19.9	36.1 ± 14.7	54.5 ± 17.8	0.025
Multifocality	NA	38 (12%)	49 (29%)	0.015
Bilaterality	NA	32 (10%)	34 (20%)	0.047
PTC	NA	197 (62%)	159 (94%)	0.005
FVPTC	NA	74 (23%)	7 (4%)	0.044
FTC	NA	25 (8%)	3 (2%)	0.034
Others	NA	22 (7%)	0	0.008
HT+	163 (10%)	57 (18%)	98 (58%)	0.001

	HT+			HT-
	FNAC	Definitive histology		FNAC	Definitive histology
		Benign	Malignant		Benign	Malignant
ND/UNS	6%	0%	13%	6%	7%	5%
Benign	43%	60%	20%	48%	59%	12%
AUS/FLUS	20%	25%	13%	18%	18%	15%
FN/SFN	11%	10%	13%	13%	14%	10%
SFM	11%	5%	20%	7%	2%	25%
Malignant	9%	0%	21%	8%	0%	33%

Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Sede da Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico Facial, Av. Indianópolia, 1287, 04063-002 São Paulo/SP Brasil, Tel.: (0xx11) 5053-7500, Fax: (0xx11) 5053-7512 - São Paulo - SP - Brazil
E-mail: revista@aborlccf.org.br

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[1] * Corresponding author. E-mail:b.uhliarova@gmail.com (B. Uhliarova).

Brasil

Brasil

Hashimoto's thyroiditis - an independent risk factor for papillary carcinoma☆ ☆ Please cite this article as: Uhliarova B, Hajtman A. Hashimoto's thyroiditis - an independent risk factor for papillary carcinoma. Braz J Otorhinolaryngol. 2018;84:729-35.

Abstract

Introduction:

Objective:

Methods:

Results:

Conclusion:

Hashimoto's thyroiditis - an independent risk factor for papillary carcinoma^☆ ☆ Please cite this article as: Uhliarova B, Hajtman A. Hashimoto's thyroiditis - an independent risk factor for papillary carcinoma. Braz J Otorhinolaryngol. 2018;84:729-35.