Auditory evoked potentials in a newborn Wistar rat model of hyperbilirubinemia

Gökdogan, Çagil; Genç, Aydan; Gülbahar, Özlem; Gökdogan, Ozan; Helvaci, Ayse; Bezgin, Selin Üstün; Memis, Leyla

doi:10.1016/j.bjorl.2015.10.008

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Brazilian Journal of Otorhinolaryngology

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ORIGINAL ARTICLES • Braz. j. otorhinolaryngol. 82 (2) • Mar-Apr 2016 • https://doi.org/10.1016/j.bjorl.2015.10.008 copy

Auditory evoked potentials in a newborn Wistar rat model of hyperbilirubinemia ^{^☆} ☆ Please cite this article as: Gökdogan Ç, Genç A, Gülbahar Ö, Gökdogan O, Helvaci A, Bezgin SÜ, et al. Auditory evoked potentials in a newborn Wistar rat model of hyperbilirubinemia. Braz J Otorhinolaryngol. 2016;82: 144-50. ^{^☆☆} ☆☆ Institution: Gazi University Hospital Department of Audiology, Ankara, Turkey.

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

INTRODUCTION:

Hyperbilirubinemia is a common health problem in newborns. Its effects can be different according to the level and duration of the hyperbilirubinemia. The toxic effect of bilirubin on the auditory system can be seen as a sensory neural hearing loss or auditory neuropathy spectrum disorder (ANSD).

OBJECTIVE:

The purpose of our study was to determine the effects of toxic bilirubin level on the auditory system by using Auditory Brainstem Response audiometry.

METHODS:

Rats are used as animal models due to their low cost and easy attainability. Auditory Brainstem Response was used for auditory assessment. In this study, three groups were established: experimental, control and placebo groups.

RESULTS:

In the experimental group, which consists of rats with hyperbilirubinemia, sensory neural hearing loss was found bilaterally in 4 rats (66.67%) and unilaterally in 2 rats (16.67%) and auditory neuropathy spectrum disorder was found unilaterally in 1 rat (8.33%). Auditory Brainstem Response thresholds were significantly elevated compared to control and placebo groups (p < 0.05).

CONCLUSION:

Hyperbilirubinemia of newborn rats may result both in sensory neural hearing loss and auditory neuropathy spectrum disorder.

Keywords:
Hyperbilirubinemia; Wistar rats; Sensorineural hearing loss; Auditory evoked potentials

Rats	Groups	TcB1	TcB2	TcB3	TcB4	STB	ABR right	ABR left
1	Experiment	0.01	0.89	0.72	0.56	0.61	30	40
2		0.01	0.86	0.62	0.4	0.23	30	30
3		0.02	0.92	0.7	0.2	0.15	10	10
4		0.01	0.96	0.69	0.5	0.58	NR	NR
5		0.03	0.72	0.4	0.28	0.23	20	30
6		0.02	0.9	0.74	0.62	0.69	40	50
1	Placebo	0.01	0.03	0.02	0.38	0.46	20	0
2		0.01	0.02	0.04	0.4	0.43	NR	NR
3		0.02	0.05	0.04	0.28	0.33	20	20
4		0.02	0.02	0.05	0.22	0.3	-10	0
5		0.01	0.05	0.03	0.38	0.44	10	10
6		0.01	0.02	0.04	0.3	0.42	10	10
1	Control	0.03	0.03	0.04	0.06	0.08	NR	NR
2		0.01	0.01	0.03	0.15	0.17	20	10
3		0.01	0.01	0.02	0.1	0.17	10	20
4		0.01	0.01	0.02	0.02	0.03	10	20
5		0.02	0.02	0.04	0.09	0.15	10	10
6		0.01	0.01	0.03	0.1	0.17	10	0

	Group	Mean	SD	Median	Min–max
Right ear	Control	12.00	4.47	10	10–20
ABR threshold	Placebo	10.00	12.25	10	-10–20
	Experiment	26.00	11.40	30	10–40
Left ear	Control	12.00	8.37	10	10–20
ABR threshold	Placebo	8.00	8.37	10	0–20
	Experiment	32.00	14.83	30	10–50

Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Sede da Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico Facial, Av. Indianópolia, 1287, 04063-002 São Paulo/SP Brasil, Tel.: (0xx11) 5053-7500, Fax: (0xx11) 5053-7512 - São Paulo - SP - Brazil
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[1] * Corresponding author. E-mail:cagilgokdogan@gmail.com (Ç. Gökdŏgan).