Kim et al., 20111010 Kim DW, Khalmuratova R, Hur D, Jeon SY, Kim SW, Shin HW, et al. Staphylococcus aureus enterotoxin B contributes to induction of nasal polypoid lesions in an allergic rhinosinusitis murine model. Am J Rhinol Allergy. 2011;25, e-255-261. (Model A) |
15 |
SEB: 5ng (IN)
OVA: IP: 25 μg and IN: 3%
|
103 |
0–4 |
150 |
Kim et al., 20111010 Kim DW, Khalmuratova R, Hur D, Jeon SY, Kim SW, Shin HW, et al. Staphylococcus aureus enterotoxin B contributes to induction of nasal polypoid lesions in an allergic rhinosinusitis murine model. Am J Rhinol Allergy. 2011;25, e-255-261. (Model B) |
15 |
SEB: 500ng (IN)
OVA: IP: 25 μg and IN: 3%
|
103 |
0–3 |
80 |
Kim et al., 20133939 Hong SL, Zhang YL, Kim SW, Kim DW, Cho SH, Chang YS, et al. Interleukin-17A-induced inflammation does not influence the development of nasal polyps in murine model. Int Forum Allergy Rhinol. 2015;5:363–70. (Model C) |
20 |
SEB: 10ng (IN)
OVA: IP: 25 μg and IN: 3%
|
103 |
1-4 |
100–200 |
Lee et al., 2014[47] (Model C) |
8 |
SEB: 10ng (IN)
OVA: IP: 25 μg and IN: 3%
|
103 |
3 |
50 |
Hong et al., 20154141 Kim DW, Eun KM, Jin HR, Cho SH, Kim DK. Prolonged allergen exposure is associated with increased thymic stromal lymphopoietin expression and Th2-skewing in mouse models of chronic rhinosinusitis. Laryngoscope. 2016;126:E265–272. (Model C) |
15 |
SEB: 10ng (IN)
OVA: IP: 25 μg and IN: 3%
|
103 |
1-2 |
60–100 |
Shin et al. 20154040 Chang DY, Joo YH, Kim SJ, Kim JH, Jung MH, Kim DW, et al. Therapeutic effects of intranasal cyclosporine for eosinophilic rhinosinusitis with nasal polyps in a mouse model. Am J Rhinol Allergy. 2015;29:e29–32. (Model C) |
10 |
SEB: 10ng (IN)
OVA: IP: 25 μg and IN: 3%
|
103 |
3-4 |
40–60 |
Chang et al., 20154242 Lee M, Kim DW, Khalmuratova R, Shin SH, Kim YM, Han DH, et al. The IFN-γ-p38, ERK kinase axis exacerbates neutrophilic chronic rhinosinusitis by inducing the epithelial-to-mesenchymal transition. Mucosal Immunol. 2019;12:601–11. (Model C) |
10 |
SEB: 10ng
OVA: IP: 25 μg and IN: 3%
|
103 |
1-3 |
40 –70 |
Kim et al., 20164343 Choi MR, Xu J, Lee S, Yeon SH, Park SK, Rha KS, et al. Chloroquine treatment suppresses mucosal inflammation in a mouse model of eosinophilic chronic rhinosinusitis. Allergy Asthma Immunol Res. 2020;12:994–1011. (Model C) |
11 |
SEB: 10ng
OVA: IP: 25 μg and IN: 3%
|
103 |
2-4 |
50 |
Kim et al., 20164343 Choi MR, Xu J, Lee S, Yeon SH, Park SK, Rha KS, et al. Chloroquine treatment suppresses mucosal inflammation in a mouse model of eosinophilic chronic rhinosinusitis. Allergy Asthma Immunol Res. 2020;12:994–1011. (Model D) |
8 |
SEB: 10ng
OVA: IP: 25 μg and IN: 3%
|
186 |
8–12 |
150 |
Lee et al., 20171414 Lee M, Park CG, Huh BK, Kim SN, Lee SH, Khalmuratova R, et al. Sinonasal delivery of resveratrol via mucoadhesive nanostruc-tured microparticles in a nasal polyp mouse model. Sci Rep. 2017;7:40249. (Model C) |
7 |
SEB: 10ng
OVA: IP: 25 μg and IN: 3%
|
103 |
4 - 8 |
150
|
Choi et al., 20204545 Wee JH, Ko YK, Khalmuratova R, Shin HW, Kim DW, Rhee CS. Effect of lipopolysaccharide and polyinosinic:polycytidylic acid in a murine model of nasal polyp. Sci Rep. 2021;11:1021. (Model C) |
20 |
SEB: 10ng
OVA: IP: 25 μg and IN: 3%
|
103 |
5 –20 |
40–70 |
Joo et al., 20214646 Lee K Il, Kim DW, Kim EH, Kim JH, Samivel R, Kwon JE, et al. Cigarette smoke promotes eosinophilic inflammation, airway remodeling, and nasal polyps in a murine polyp model. Am J Rhinol Allergy. 2014;28:208–14. (Model C) |
10 |
SEB: 10ng
OVA: IP: 25 μg and IN: 3%
|
103 |
2–4 |
80–150 |
Wee et al., 20213838 Shin HW, Kim DK, Park MH, Eun KM, Lee M, So D, et al. IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2015;135:1476–85.e7. (Model C) |
10 |
SEB: 10ng
OVA: IP: 25 μg and IN: 3%
|
103 |
1 - 5 |
20–30 |