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Original articles • Braz. j. otorhinolaryngol. 86 (5) • Sep-Oct 2020 • https://doi.org/10.1016/j.bjorl.2019.04.002   copy

In vivo and in vitro study of co-expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma☆ ☆ Please cite this article as: Ye Q, Li J, Wang X, Zhang X, Lin J, Huo Y, et al. In vivo and in vitro study of co-expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma. Braz J Otorhinolaryngol. 2019. https://doi.org/10.1016/j.bjorl.2019.04.002

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Abstract

Introduction:

Nasopharyngeal carcinoma, an epithelial-derived malignant tumor which because of its anatomical location and atypical early symptoms, when diagnosed invasion and metastasis often have occurred. This requires a better understanding of the development mechanism, identifying diagnostic markers, and developing new treatment strategies.

Objective:

To study the relationship of LMP1 and Cripto-1 in nasopharyngeal carcinoma.

Methods:

The expression of LMP1 and Cripto-1 in specimens obtained from nasopharyngeal carcinoma patients (n = 42) and nasopharyngitis patients (n = 22) were examined. The expression of LMP1 and Cripto-1 in LMP1-negative and LMP1-positive (CNE1-LMP1) cells were also examined.

Results:

The expression of LMP1 and Cripto-1 was significantly higher in nasopharyngeal carcinoma than in nasopharyngitis (p < 0.05). Their expression in nasopharyngeal carcinoma with metastasis were significantly higher than that without metastasis (p < 0.05), which was correlated with TNM staging (p < 0.05). High Cripto-1 expression and high proliferation rate were seen in CNE1-LMP1 cells.

Conclusions:

The expression of LMP1 and Cripto-1 in nasopharyngeal carcinoma is positively related. Their co-expression might contribute to the proliferation and metastasis of nasopharyngeal carcinoma.

KEYWORDS
Nasopharyngeal carcinoma; LMP1; Cripto-1; Metastasis

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