Joachims et al., 20032727 Joachims HZ, Segal J, Golz A, Netzer A, Goldenberg D. Antioxidants in treatment of idiopathic sudden hearing loss. Otol Neurotol. 2003;24:572-5.
|
Sudden hearing loss (<7 days) |
Group C: prednisone (1 mg/kg/day); magnesium sulfate intravenous (4 g/day); carbogen through mask (95% O2 + 5% CO2) - 30 min/4 × /day |
Vitamin E |
Grupo S - 400 mg (2 × /day) |
|
Pure-tone and vocal audiometry. |
Group C - 45.45% (n = 15) showed the result |
Improvement of 75% or more in the recovery rate |
Vitamin E was found as being beneficial in the treatment of sudden hearing loss |
|
Group C - improved N: 15 Total N: 33 |
Group S: intervention of group C + Vitamin E (400 mg 2 × /day). |
Group S - 78.78% (n = 26) showed the result |
Group S - improved N: 26 Total N: 33 |
|
Kharkeli et al., 20072828 Kharkeli E, Kevanishvili Z, Maglakelidze T, Davitashvili O, Schacht J. Does Vitamin E prevent gentamicin-induced ototoxicity?. Georgian Med News. 2007;:14-7.
|
Induced by ototoxic substances. |
Experimental group - 80 mg gentamicin (3×/day) + Vitamin E (2800 mg/day in three doses: 1200 mg, 800 mg, 800 mg) |
[1,0]Vitamin E |
[1,0]2800 mg/day in three doses: 1200 mg; 800 mg; 800 mg) |
[1,0]7 days |
[1,0]Pre- and post-pure-tone audiometry |
[1,0]Auditory thresholds increased in a similar number of patients from both groups, but with no statistical difference |
The analyzed criteria showed no statistical difference |
[1,0]Vitamin E is not clinically effective against gentamicin-induced ototoxicity. However, due to the limited number of subjects, the conclusion should be considered delicate |
Control group Improved N: 26 Total N: 29 |
Control group - 80 mg gentamicin (3×/day) + placebo (peanut oil, gelatin, glycerin and sorbitol) |
Experimental group Improved N: 20 Total N: 23 |
Polanski and Cruz, 20132626 Polanski JF, Cruz OL. Evaluation of antioxidant treatment in presbyacusis: prospective, placebo-controlled, double-blind, randomised trial. J Laryngol Otol. 2013;127:134-41.
|
Presbycusis. |
Group 1 - ginkgo biloba (120 mg/day) |
Ginkgo biloba; α-lipoic acid + Vitamin C; Vitamin E. |
Ginkgo biloba (120 mg/day); α-lipoic acid (60 mg/day) + Vitamin C (600 mg/day); Vitamin E (400 mg/day) |
6 months |
Pre- and post-pure-tone and vocal audiometry |
There were differences in the audiological thresholds: 500 Hz, 1000 Hz and 8000 Hz, being greater for group 4 when compared to group 2 |
The results before and after treatment were not significantly different in any treatment group |
The results did not show a statistically significant difference of the effects of antioxidant substances on the auditory thresholds of this population during the 6-month study period |
Group 2 - α-lipoic acid (60 mg/day) + vitamin C (600 mg/day) |
Group 3 - papaverine hydrochloride (100 mg/day) + vitamin E (400 mg/day) |
Group 4 - placebo. |
Doosti et al., 20142424 Doosti A, Lofti Y, Moosavi A, Bakhshi E, Talasaz AH. Distortion product otoacoustic emission (DPOAE) as an appropriate tool in assessment of otoprotective effects of antioxidants in noise-induced hearing loss (NIHL). Indian J Otolaryngol Head Neck Surg. 2014;66:325-9.
|
Noise-induced hearing loss. |
Control group - no intervention |
Ginseng |
Ginseng group - 200 mg/day |
14 days (2 weeks) |
Distortion product otoacoustic emissions - DPOAE (1, 2, 4 and 6 kHz) |
NAC and ginseng groups showed the result; additionally, the NAC group showed better amplitude of DPOAE than the ginseng group |
Reduced DPOAE amplitude at high frequencies (4 and 6 kHz) in both ears |
The generalization of the results found in relation to the protective effects of these interventions requires assays with different doses and in a larger population |
NAC group - NAC 1200 mg/day |
Control group N improved: Total N: 16 |
Ginseng group- 200 mg/day. |
NAC group N improved: Total N: 16 |
Ginseng group N improved: Total N: 16 |
Doosti et al., 20142525 Doosti A, Lofti Y, Moosavi A, Bakhshi E, Talasaz AH, Hoozard A. Comparison of the effects of N-acetyl-cysteine and ginseng in prevention of noise induced hearing loss in male textile workers. Noise Health. 2014;16:223-7.
|
Noise-induced hearing loss |
Control group - no intervention; |
Ginseng |
Group G - ginseng 200 mg/day |
14 days (2 weeks) |
Pre- and post-pure-tone audiometry and high-frequency audiometry |
Groups N and G showed the result |
Reduced the temporary change in auditory threshold (4, 6 and 16 kHz) |
NAC and ginseng showed to have preventive effects of NIHL. This beneficial effect was most often seen in Group N |
Group N - NAC 1200 mg/day |
Group N showed greater reduction |
Control group Improved N: Total N: 16 |
Group G -ginseng 200 mg/day. |
Group NAC Improved N: Total N: 16 |
Ginseng group Improved N: Total N: 16 |