1 |
Zhang1313 Zhang M, Chia C, Stanley C, Phyland DJ, Paddle PM. Diagnostic utility of salivary pepsin as compared with 24-hour dual pH/impedance probe in laryngopharyngeal reflux. Otolaryngol Head Neck Surg. 2021;164:375–80.
|
2020 |
Australia |
Adult |
26/4 |
OC |
PH monitoring |
16/75 |
2 |
Bozzani1616 Bozzani A, Grattagliano I, Pellegatta G, Furnari M, Galeone C, Savarino V, et al. Usefulness of pep-test for laryngo-pharyngeal reflux: a pilot study in primary care. Korean J Fam Med. 2020;41:250–5.
|
2020 |
Italy |
Adult |
76/59 |
HC and OC |
Symptoms |
25 |
3 |
Klimara1515 Klimara MJ, Johnston N, Samuels TL. Correlation of salivary and nasal lavage pepsin with MII-pH testing. Laryngoscope. 2020;130:961–6.
|
2019 |
USA |
Adult |
19/7 |
OC |
PH monitoring and symptoms, signs |
/ |
4 |
Weitzendorfer1414 Weitzendorfer M, Antoniou SA, Schredl P, Witzel K, Weitzendorfer IC, Majerus A, et al. Pepsin and oropharyngeal pH monitoring to diagnose patients with laryngopharyngeal reflux. Laryngoscope. 2020;130:1780–6.
|
2019 |
Austria |
Adult |
41/29 |
OC |
PH monitoring and symptoms, signs |
16/50/100/150/216 |
5 |
Barona-Lleo1717 Barona-Lleo L, Barona-De Guzman R, Krstulovic C. The diagnostic usefullness of the salivary pepsin test in symptomatic laryngopharyngeal reflux. J Voice. 2019;33: 923–8.
|
2018 |
Spain |
Adult |
180/41 |
HC |
Symptoms |
/ |
6 |
Fortunato1818 Fortunato JE, D’Agostino RB Jr, Lively MO. Pepsin in saliva as a biomarker for oropharyngeal reflux compared with 24-hour esophageal impedance/pH monitoring in pediatric patients. Neurogastroenterol Motil. 2017;29.
|
2017 |
USA |
Paediatric |
20/113 |
HC and OC |
PH monitoring |
5/7/10/30/50 |
7 |
Dy 1919 Dy F, Amirault J, Mitchell PD, Rosen R. Salivary pepsin lacks sensitivity as a diagnostic tool to evaluate extraesophageal reflux disease. J Pediatr. 2016;177:53–8.
|
2016 |
USA |
Paediatric |
24/26 |
OC |
PH monitoring |
74 |
8 |
Yadlapati2020 Yadlapati R, Adkins C, Jaiyeola DM, Lidder AK, Gawron AJ, Tan BK, et al. Abilities of oropharyngeal pH tests and salivary pepsin analysis to discriminate between asymptomatic volunteers and subjects with symptoms of laryngeal irritation. Clin Gastroenterol Hepatol. 2016;14:535–42, e2.
|
2016 |
USA |
Adult |
15/18 |
HC |
Symptoms |
16 |
9 |
Hayat2121 Hayat JO, Gabieta-Somnez S, Yazaki E, Kang JY, Woodcock A, Dettmar P, et al. Pepsin in saliva for the diagnosis of gastrooesophageal reflux disease. Gut. 2015;64:373–80.
|
2015 |
UK |
Adult |
84/114 |
HC and OC |
PH monitoring and symptoms |
16/50/100/150/210 |
10 |
Ocak2222 Ocak E, Kubat G, Yorulmaz ˙I. Immunoserologic pepsin detection in the saliva as a non-invasive rapid diagnostic test for laryngopharyngeal reflux. Balkan Med J. 2015;32:46–50.
|
2015 |
USA |
Adult |
18/2 |
OC |
PH monitoring |
16 |
11 |
Spyridoulias(a)2323 Spyridoulias A, Lillie S, Vyas A, Fowler SJ. Detecting laryngopharyngeal reflux in patients with upper airways symptoms: symptoms, signs or salivary pepsin? Respir Med. 2015;109:963–9.
|
2015 |
UK |
Adult |
68/10 |
OC |
Symptoms |
16 |
11 |
Spyridoulias(b)2323 Spyridoulias A, Lillie S, Vyas A, Fowler SJ. Detecting laryngopharyngeal reflux in patients with upper airways symptoms: symptoms, signs or salivary pepsin? Respir Med. 2015;109:963–9.
|
2015 |
UK |
Adult |
40/38 |
OC |
Signs |
16 |
12 |
Hayat2424 Hayat JO, Yazaki E, Moore AT, Hicklin L, Dettmar P, Kang JY, et al. Objective detection of esophagopharyngeal reflux in patients with hoarseness and endoscopic signs of laryngeal inflammation. J Clin Gastroenterol. 2014;48:318–27.
|
2014 |
UK |
Adult |
21/10 |
HC |
Symptoms |
25 |
13 |
Saritas2525 Saritas Yuksel E, Hong SK, Strugala V, Slaughter JC, Goutte M, Garrett CG, et al. Rapid salivary pepsin test: blinded assessment of test performance in gastroesophageal reflux disease. Laryngoscope. 2012;122:1312–6.
|
2012 |
UK |
Adult |
22/25 |
OC |
PH monitoring |
50 |
14 |
Kim2626 Kim TH, Lee KJ, Yeo M, Kim DK, Cho SW. Pepsin detection in the sputum/saliva for the diagnosis of gastroesophageal reflux disease in patients with clinically suspected atypical gastroesophageal reflux disease symptoms. Digestion. 2008;77:201–6.
|
2008 |
Korea |
Adult |
9/39 |
HC and OC |
PH monitoring |
/ |
15 |
Printza2727 Printza A, Speletas M, Triaridis S, Wilson J. Is pepsin detected in the saliva of patients who experience pharyngeal reflux? Hippokratia. 2007;11:145–9.
|
2007 |
Greece |
Adult |
9/2 |
HC |
Symptoms and signs |
/ |
16 |
Potluri2828 Potluri S, Friedenberg F, Parkman HP, Chang A, MacNeal R, Manus C, et al. Comparison of a salivary/sputum pepsin assay with 24-hour esophageal pH monitoring for detection of gastric reflux into the proximal esophagus, oropharynx, and lung. Dig Dis Sci. 2003;48:1813–7.
|
2003 |
USA |
Adult |
3/13 |
OC |
PH monitoring |
/ |