Sematonyte et al., 20182525 Semantonyte J, Bajouriene I, Satkauskiene B. Effect of intranasal phototherapy on quality-of-life of patients with allergic rhinitis. In: Abstracts from the European Academy of Allergy and Clinical Immunology Congress, 26-30 May 2018, Munich, Germany. Clin Transl Allergy. 2018;73 Suppl 105:3-859.
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15 |
UV-A (25%), UV-B (5%) laser, visible light (70%), 310-600 nm |
To investigate the effect of endonasal phototherapy on the quality of life of patients with perennial AR. |
Endonasal phototherapy can relieve nasal symptoms and improve quality of life of patients with moderate/severe AR. |
Prospective |
High |
Bella et al., 20171313 Bella Z, Kiricsi Á, Viharosné ÉDR, Dallos A, Perényi Á, Kiss M, et al. Rhinophototherapy in persistent allergic rhinitis. Eur Arch Otorhinolaryngol. 2017;274:1543-50.
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25 |
UV-A (25%), UV-B (5%) laser, visible light (70%), 310-600 nm |
To evaluate whether endonasal phototherapy is safe and effective in the treatment of perennial AR. |
Endonasal phototherapy is an effective and safe treatment in perennial AR. |
Prospective, randomized, double-blind, placebo controlled |
High |
Alyasin et al., 20161010 Alyasin S, Nabavizadeh SH, Houshmand H, Esmaeilzadeh H, Jelodar S, Amin R. Short time efficiency of rhinophototherapy in management of patients with allergic rhinitis resistant to medical therapy. Iran J Allergy Asthma Immunol. 2016;15:317-27.
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62 |
UV-A (25%), UV-B (5%) laser, visible light (70%), 310-600 nm |
Treat AR with phototherapy in patients who are unresponsive to treatment with antihistamines or in those whose work contraindicates the use of the drug, or who do not use medication. |
Endonasal phototherapy was an effective treatment in patients with AR. However, a grounding study is still recommended. |
Prospective, randomized and blind |
High |
Lee et al., 20132626 Lee HM, Park MS, Park IH, Lee SH, Lee SK, Kim KS, et al. A comparative pilot study of symptom improvement before and after phototherapy in Korean patients with perennial allergic rhinitis. Photochem Photobiol. 2013;89:751-7.
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42 |
LED 650 nm |
To evaluate the safety and efficacy of low energy phototherapy in patients with perennial AR. |
Phototherapy is effective for the treatment of perennial AR and is a therapeutic option in the treatment management without the use of steroids, of immune-mediated diseases of the nasal mucosa |
Open clinical study |
High |
Albu and Baschir, 20132020 Albu S, Baschir S. Intranasal phototherapy versus azelastine in the treatment of seasonal allergic rhinitis. Auris Nasus Larynx. 2013;40:447-51.
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77 |
UV-A (25%), UV-B (5%) laser, visible light (70%), 310-600 nm |
To compare the effectiveness of rhinophototherapy and azelastine hydrochloride for the treatment of seasonal AR. |
Both rhinophototherapy and azelastine hydrochloride are capable of significantly improving TNSS. |
Randomized, prospective |
Medium |
Yildirim; Apuhan e Kocoglu, 20132727 Yildirim YS, Apuhan T, Koçoˇglu E. Effects of intranasal phototherapy on nasal microbial flora in patients with allergic rhinitis. Iran J Allergy Asthma Immunol. 2013;12:281-6.
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31 |
UV-A (25%), UV-B (5%) laser, visible light (70%), 310-600 nm |
To evaluate the effect of endonasal phototherapy on the microbial flora in a patient with AR. |
Endonasal phototherapy does not change the aerobic microbial flora of the nasal mucosa in patients with perennial AR. |
Prospective, self-compared and blind. |
High |
Garaczi et al., 20111212 Garaczi E, Boros-Gyevi M, Bella Z, Csoma Z, Kemény L, Koreck A. Intranasal phototherapy is more effective than fexofenadine hydrochloride in the treatment of seasonal allergic rhinitis: Results of a pilot study. Photochem Photobiol. 2011;87:474-7.
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|
UV-A (25%), UV-B (5%) laser, visible light (70%), 310-600 nm |
To compare the efficacy between endonasal phototherapy and fexofenadine hydrochloride, in the treatment of seasonal AR. |
Endonasal phototherapy is more effective than fexofenadine hydrochloride in reducing clinical symptoms of seasonal AR. |
Randomized prospective, |
High |
Bremher and Schön, 20112828 Brehmer D, Schön MP. Endonasal phototherapy significantly alleviates symptoms of allergic rhinitis, but has a limited impact on the nasal mucosal immune cells. Eur Arch Otorhinolaryngol. 2011;268:393-9.
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10 |
UV-A (25%), UV-B (5%) laser, visible light (70%), 310-600 nm |
To correlate clinical symptom scores with possible changes in Langerhans cells of the nasal mucosa induced by ultraviolet irradiation |
The irradiation effect was positive, however, no effect was observed on Langerhans cells or other cells of the nasal mucosa immune system. |
Open clinical study |
High |
Cingi et al., 20101414 Cingi C, Cakli H, Yaz A, Songu M, Bal C. Phototherapy for allergic rhinitis: a prospective, randomized, single-blind, placebocontrolled study. Ther Adv Respir Dis. 2010;4:209-13.
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79 |
UV-A (25%), UV-B (5%) laser, visible light (70%), 310-600 nm |
To investigate the effectiveness of phototherapy treatment in patients with AR using TNSS. |
Phototherapy can be an effective modality in the treatment of AR, especially when the drugs used are contraindicated and/or show insufficient efficacy |
Prospective, randomized, blind, placebo-controlled |
Medium |
Csoma et al., 200644 Csoma Z, Koreck A, Ignacz F, Bor Z, Szabo G, Bodai L, et al. PUVA treatment of the nasal cavity improves the clinical symptoms of allergic rhinitis and inhibits the immediate-type hypersensitivity reaction in the skin. J Photochem Photobiol B. 2006;83:21-6.
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13 |
PUVA laser 305-440 nm |
To investigate the efficacy of endonasal PUVA light in the treatment of AR and its effect on skin testing. |
Phototherapy plus UV-A is also an effective modality in the treatment of AR. |
Open clinical study |
Medium |
Koreck et al., 200522 Koreck AI, Csoma Z, Bodai L, Ignacz F, Kenderessy AS, Kadocsa E, et al. Rhinophototherapy: a new therapeutic tool for the management of allergic rhinitis. J Allergy Clin Immunol. 2005;115:541-7.
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49 |
UV-A (25%), UV-B (5%) laser, visible light (70%), 310-600 nm |
To assess whether phototherapy, using a combination of UV-B, UV-A and visible light, is effective in the treatment of AR. |
Phototherapy is an effective modality for the treatment of AR and immune-mediated diseases of the mucous membranes. |
Randomized, double blind |
Low |
Csoma et al., 200411 Csoma Z, Ignacz F, Bor Z, Szabo G, Bodai L, Dobozy A, et al. Intranasal irradiation with the xenon chloride ultraviolet B laser improves allergic rhinitis. J Photochem Photobiol B. 2004;75:137-44.
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15 |
XeCL laser UV-B 308 nm |
To investigate the clinical efficacy of UV-B irradiation in AR. |
It suggests that the XeCL UV-B laser may be a new therapeutic tool in AR. |
Open clinical study |
High |