Combinations
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NSAIDs + Diuretics |
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X |
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NSAIDS + Meperidine ou Pentazocine |
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X |
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NSAIDS + Piroxicam, Ketorola or Mefenamic acid |
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X |
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NSAIDS + ACEi |
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X |
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NSAIDS + SSRI |
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X |
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NSAIDS + Warfarin |
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X |
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X |
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X |
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Amitriptyline + Chlordiazepoxide |
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X |
X |
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X
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Amitriptyline + Perphenazine |
X
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X
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X
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X
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Anticholinergic + Antipsychotics |
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X |
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X |
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Cimetidine + Warfarin |
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X |
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Clidinium + Chlordiazepoxide |
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X |
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X
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Corazepato + Acepromazine |
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X |
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Desclorfeniramina + Betamethasone |
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X |
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SSRI + MAOI |
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X |
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Methyldopa + Hydrochlorothiazide |
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X |
X |
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Dose limits, frequency and duration of treatment
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Acetylsalicylic acid ≥150mg/dia (dose) |
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X |
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Pain relievers containing codeine |
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X |
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Antibiotics prescribed for the first crisis of bronchitis |
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X |
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Gastrointestinal antispasmodics |
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X |
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1st generation antihistamines (duration) |
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X |
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Antipsychotic drugs (dose, duration) |
X
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X |
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Antipsychotics for nonpsychotic diagnoses |
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X |
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Barbiturates (duration) |
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X |
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Benzodiazepines (dose, duration) |
X
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X |
X |
X |
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H2 blockers (dose. frequency and duration) |
X
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Decongestants (duration) |
X
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Digoxin (dose) |
X
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Iron supplements (dose and frequency) |
X
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Thiazides (dose) |
X
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X |
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Three or more psychotropic drugs (duration) |
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X |
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Interaction Pathology
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Adenoma of the prostate, glaucoma and urinary retention X
anticholinergic |
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X |
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Angina in patients with a history of asthma, COPD or heart failure X
β-blockers |
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X |
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Anorexia and malnutrition X central nervous system stimulants |
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X |
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Conductive cardiac abnormalities X tricyclic antidepressant |
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X |
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Arrhythmias X tricyclic antidepressants |
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X |
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No history of coronary symptoms, cerebral or peripheral vascular
occlusive or event X Acetylsalicylic acid |
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X |
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Chronic constipation without concomitant use of laxatives X opioids for
more than 2 weeks |
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X |
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Constipation X tricyclic antidepressant |
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X |
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Seizures X clozapine, chlorpromazine, thioridazine and thiothixene |
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X |
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Dementia X anticholinergics, trihexafenidil, tropatepina, biperiden,
neuroleptics (except risperidone and olanzapine) and benzodiazepines |
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X |
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Depression X active metabolites with tricyclic antidepressant (eg
amitriptyline or imipramine) |
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X |
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Depression X long-acting benzodiazepines and sympatholytic agents |
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X |
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Depression X methylphenidate |
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X |
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X |
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Clotting disorders X NSAIDs, dipyridamole, ticlopidine and
clopidogrel |
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X |
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Diabetes mellitus and frequent hypoglycemia X β-blockers |
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X |
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Diabetes X corticoids |
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X |
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Diarrhea or gastroenteritis of unknown cause severe X diphenoxylate,
loperamide or codeine |
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X |
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X |
X |
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Parkinson’s Disease X Metoclopramide, conventional antipsychotics,
tacrine |
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X |
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Raynaud’s DiseaseX prolonged use of β-adrenergic blocker |
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X |
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Moderate pain X long-term use of potent opioids as a first treatment
option |
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X |
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COPD X beta blockers and benzodiazepines long-term |
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X |
X |
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X |
X |
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COPD X theophylline |
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X |
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Muscle spasms X cyclobenzaprine or methocarbamol |
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X |
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Stress X benzodiazepínios beta-blockers and long acting |
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X |
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Atrial fibrillation X disopyramide |
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X |
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Drop X thiazide diuretic |
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X |
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X |
X |
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Drop X indomethacin |
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X |
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Benign prostatic hyperplasia, glaucoma or cardiac arrest X tricyclic
antidepressant |
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X |
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X |
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Moderate to severe hypertension X NSAIDS |
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X |
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X |
X |
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Hypertension X phenylpropanolamine, pseudoephedrine and
amphetamines |
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X |
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Hypertension X reserpine |
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X |
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Postural hypotension X tricyclic antidepressants |
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X |
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Postural hypotension X chlorpromazine |
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X |
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Urinary incontinence X urapidil and prazosin |
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X |
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Insomnia X decongestants, theophylline, methylphenidate, MAOI,
amphetamine |
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X |
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Insomnia X prolonged use of triazolam |
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X |
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Heart failure X NSAIDS |
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X |
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X |
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Heart failure X β-adrenergic blocker |
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X |
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X |
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Heart failure X Calcium channel blockers |
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X |
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X |
X |
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Heart failure X drugscom disopyramide and high sodium |
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X |
X |
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Chronic renal failure X NSAIDS |
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X |
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X |
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Obesity X olanzapine |
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X |
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Chronic constipation X calcium channel blockers, anticholinergics, and
tricyclic antidepressants |
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X |
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X |
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Chronic osteoarthritis X phenylbutazone |
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X |
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Moderate osteoarthritis X NSAIDS |
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X |
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X |
X |
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Osteoarthritis or rheumatoid arthritis X long-term corticosteroids |
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X |
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Parkinson X long-term neuroleptic |
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X |
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Cognitive impairment X anticholinergic or antispasmodic |
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X |
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Cognitive impairment X tricyclic antidepressant |
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X |
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Cognitive impairment X antimuscarinic |
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X |
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Cognitive impairment X barbiturates, anticholinergics, antispasmodics,
muscle relaxants and CNS stimulants |
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X |
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Cognitive impairment X niacin or pentoxifylline |
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X |
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Cognitive impairment X Prolonged use of opioids |
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X |
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Renal damage X digoxin > 0,125 mg/dia |
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X |
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Prevention of myocardial X dipyridamole |
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X |
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X |
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Chronic prostatism X antimuscarinic |
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X |
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Prostatism or history of urinary retention X tricyclic
antidepressant |
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X |
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Urinary retention X anticholinergics, antihistamines, GI
antispasmodics, muscle relaxants, oxybutynin, flavoxate, antidepressants,
and tolterodine |
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X |
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Syncope or falls X short-acting benzodiazepines or tricyclic
antidepressants or intermediate |
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X |
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Syndrome of inappropriate secretion of the hormone antidiuretic /
hyponatremia X SSRI |
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X |
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Tendency to fall X benzodiazepines, neuroleptics, vasodilators and
long-term opioid |
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X |
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Maintenance therapy of moderate to severe COPD X corticoids |
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X |
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Dizziness X bupropion |
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X |
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Treatment of gout when there is no contraindication to allopurinol X
prolonged use of NSAIDS or colchicine |
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X |
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Peptic ulcer without H2 antagonist or proton pump inhibitor X
acetylsalicylic acid |
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X |
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Peptic ulcer X proton pump inhibitor in the highest therapeutic dose
for more than 8 weeks |
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X |
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UlcerX NSAIDS |
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X |
X |
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X |
X |
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Questionable efficacy
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Benzodiazepines |
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X |
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Drugs that act in the gastrointestinal tract with anticholinergic
properties |
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X |
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Cerebral vasodilator |
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X |
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