In vivo
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Upregulating PPAR-α protein |
Chan et al., 2018Chan JKW, Bittner S, Bittner A, Atwal S, Shen WJ, Inayathullah M, et al. Nordihydroguaiaretic acid, a lignan from Larrea tridentata (creosote bush), protects against american lifestyle-induced obesity syndrome diet- induced metabolic dysfunction in mice. J Pharmacol Exp Ther. 2018;365(2):281-90.
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In vitro
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Inhibition of lipoxygenase |
Bibikova et al., 2017Bibikova MV, Spiridonova NA, Korystova AF, Kublik LN, Levitman MK, Shaposhnikova VV, et al. Lipoxygenase inhibitors nordihydroguaiaretic acid and fungus Lecanicillum lecanii extract induce death of lymphoid leukemia cells. Bull Exp Biol Med. 2017;163(3):330-3.
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In vivo
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Spermatogenesis and antioxidant |
Abbas, Badran, Disi, 2018Abbas MA, Badran D, Disi A. Effect of nordihydroguaiaretic acid on spermatogenesis and fertility in rats. Andrologia. 2018;50(3)1-9.
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In vitro
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Inhibition of viral replication |
Merino-Ramos et al., 2017Merino-Ramos T, Jiménez ON, Saiz JC, Martín-Acebes MA. Antiviral activity of nordihydroguaiaretic acid and its derivative tetra-O-methyl nordihydroguaiaretic acid against West Nile virus and Zika virus. Antimicrob Agents Chemother. 2017;61(8):e00376-17.
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In vivo
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Anti-anaphylactic action |
Bergren,Valentine, 2016Bergren DR, Valentine JL. Anti-anaphylactic action of nordihydroguaiaretic acid in antigen sensitized guinea pigs. Respir Physiol Neurobiol. 2016;234:26-31.
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In vitro
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GLUT-1 Inhibitor |
Leon et al., 2016Leon D, Parada D, Vargas-Uribe M, Perez AA, Ojeda L, Zambrano A, et al. Effect of nordihydroguaiaretic acid on cell viability and glucose transport in human leukemic cell lines. FEBS Open Bio. 2016;6(10):1000-07.
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In vivo/In vitro
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Chemopreventive potential / Synergism |
Kimura, Huang, 2016Kimura K, Huang RCC. Tetra-O-methyl nordihydroguaiaretic acidbroadlysuppressescancermetabolismandsynergistically induces strong anticancer activity in combination with etoposide, rapamycin and ucn-01. Plos One. 2016;11(2):1-28.
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In vivo/In vitro
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Synergism with antibiotics |
Cunningham-Oakes et al., 2015Cunningham-Oakes E, Soren O, Moussa C, Rathor G, Liu Y, Coates A, et al. Nordihydroguaiaretic acid enhances the activities of aminoglycosides against methicillin- sensitive and resistant Staphylococcus aureus in vitro and in vivo. Front Microbiol. 2015;6:1-8.
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In vitro
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Melanogenesis in human melanoma cells |
Takekoshi, Nagata, Kitatani, 2014Takekoshi S, Nagata H, Kitatani K. Stimulation of melanogenesis by nordihydroguaiaretic acid in human melanoma cells. Acta Histochem Cytochem. 2014;47(5):203-10.
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In vitro
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Inhibition of the G1 phase of the cell cycle |
Gao et al., 2011Gao P, Zhai F, Guan L, Zheng J. Nordihydroguaiaretic acid inhibits growth of cervical cancer SiHa cells by up- regulating p21. Oncol Lett. 2011;2(1):123-28.
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Cui et al., 2008Cui Y, Lu C, Liu L, Sun D, Yao N, Tan S, et al. Reactivation of methylation-silenced tumor suppressor gene p16INK4a by nordihydroguaiaretic acid and its implication in G1 cell cycle arrest. Life Sci. 2008;82(5-6):247-255.
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