Firmino et al., 2015Firmino PYM, Vasconcelos TO, Ferreira CC, Moreira LM, Romero NR, Dias LA, et al. Cardiovascular risk rate in hypertensive patients attended in primary health care units: The influence of pharmaceutical care. Braz J Pharm Sci . 2015;51(3):617-28.
|
Fortaleza, CE |
Public |
RCTc
|
Medication therapy management |
Patients (26/30) |
Hypd/CADe
|
Clinical |
DRPf
|
Mourão et al., 2013Mourão AOM, Ferreira WR, Martins MAP, Reis AMM, Carrillo MRG, Guimarães AG, et al. Pharmaceutical care program for type 2 diabetes patients in Brazil: A randomised controlled trial. Int J Clin Pharm . 2013;35(1):79-86.
|
Ouro Preto, MG |
Public |
RCT |
Medication therapy management |
Patients (50/50) |
DM2g
|
Clinical |
Medication used profile |
Obreli-Neto et al., 2011aObreli-Neto PR, Guidoni CM, Baldoni A de O, Pilger D, Cruciol-Souza JM, Gaeti-Franco WP, et al. Effect of a 36-Month Pharmaceutical Care Program on Coronary Heart Disease Risk in Elderly Diabetic and Hypertensive Patients. J Pharm Pharm Sci. 2011a;14(2):249-63., 2011bObreli-Neto PR, Guidoni CM, Baldoni A de O, Pilger D, Cruciol-Souza J, Gaeti-Franco WP, et al. Effect of a 36-month pharmaceutical care program on pharmacotherapy adherence in elderly diabetic and hypertensive patients. Int J Clin Pharm . 2011b;33(4):642-9., 2015Obreli-Neto PR, Marusic S, Guidoni CM, Baldoni A de O, Renovato RD, Pilger D, et al. Economic evaluation of a Pharmaceutical Care Program for elderly diabetic and hypertensive patients in primary health care: a 36-month randomized controlled clinical trial. J Manag Care Spec Pharm. 2015;21(1):66-75.
|
Salto Grande, SP |
Public |
RCT |
Medication therapy management |
Patients (97/97) |
Elderly - DM2, hyp |
Clinical, economic |
Adherence |
Plaster et al., 2012Plaster CP, Melo DT, Boldt V, Cassaro KO dos S, Lessa FCR, Boëchat GAP, et al. Reduction of cardiovascular risk in patients with metabolic syndrome in a community health center after a pharmaceutical care program of pharmacotherapy follow-up. Braz J Pharm Sci . 2012;48(3):435-46.
|
Vila Velha, ES |
Public |
RCT |
Medication therapy management |
Patients (38/36) |
Metabolic syndrome |
Clinical |
Adherence |
Aguiar et al., 2012Aguiar PM, Balisa-Rocha BJ, Brito GC, Lyra DP. Pharmaceutical care program for elderly patients with uncontrolled hypertension. J Am Pharm Assoc. 2012;52(4):515-8.
|
Aracaju, SE |
Public |
Quasi-experimental |
Medication therapy management |
Patients (35) (pilot study) |
Elderly, hyp |
Clinical |
DRP, adherence |
Aguiar, Balisa-Rocha, Lyra Junior, 2013Aguiar PM, Balisa-Rocha BJ, Lyra-Júnior DP. Avaliação de indicadores de estrutura e processo de um serviço de Atenção Farmacêutica na Farmácia Popular do Brasil: um estudo piloto. Rev Ciências Farm Básica Apl. 2013;34(3):401-10.
|
Aracaju, SE |
Public |
Descriptive-evaluative |
Medication therapy management |
Pharmacists (2) and patients (69) (pilot study) |
No restriction |
Humanistic (satisfaction, patients) |
Infra-structure, follow-up process, counselling, use of EBPh, communication skills (pharmacists) |
Andrade et al., 2009Andrade TU, Burini DM, Mello M de O, Bersácula N dos S, Saliba RAD, Bravim FT, et al. Evaluation of the satisfaction level of patients attended by a Pharmaceutical Care Program in a Private Communitarian Pharmacy in Vitória (ES, Brazil). Brazilian J Pharm Sci. 2009;45(2):349-55.
|
Vitória, ES |
Private |
Cross-sectional |
Medication therapy management |
Patients (50/41) |
No restriction |
Humanistic (satisfaction) |
NA* |
Balisa-Rocha et al., 2012Aguiar PM, Balisa-Rocha BJ, Brito GC, Lyra DP. Pharmaceutical care program for elderly patients with uncontrolled hypertension. J Am Pharm Assoc. 2012;52(4):515-8.
|
Aracaju, SE |
Public |
Quasi-experimental |
Medication therapy management |
Patients (34) (pilot study) |
Elderly, DM2 |
Clinical, humanistic (QoL i) |
Medication use profile, DRP |
Brito et al., 2009 |
Aracaju, SE |
Public |
Quasi-experimental |
Medication therapy management |
Patients (30) |
Elderly |
NA |
Medication use profile |
Brune, Ferreira, Ferrari, 2014 |
Pontal do Araguaia, MT |
Public |
Quasi-experimental |
Medication therapy management |
Patients (25) |
Hyp |
Clinical |
DRP |
Cazarim et al., 2016Cazarim M, Freitas O, Penaforte T, Achcar A, Pereira L. Impact assessment of pharmaceutical care in the management of hypertension and coronary risk factors after discharge. PLoS One. 2016;11(6):2006-8., 2017Cazarim M, Nunes AA, Pereira LRL. Cost-consequence analysis of Pharmaceutical Care program for systemic arterial hypertension in the public health system in Brazil. Braz J Pharm Sci. 2017;53(3):1-10., 2018Cazarim M, Pereira L. Cost-effectiveness analysis of pharmaceutical care for hypertensive patients from the perspective of the public health system in Brazil. PLoS One . 2018;13(3):1-16.
|
Ribeirão Preto, SP |
Public |
Quasi-experimental |
Medication therapy management |
Patients (104) |
Hyp/CAD |
Clinical, humanistic (QoL), economic |
Adherence |
Correr et al., 2009a, 2009b, 2011 |
Curitiba, Paranaguá, Colombo, Campo Largo, PR |
Private |
Quasi-experimental |
Medication therapy management |
Patients (50/46) |
DM2 |
Clinical, economic, humanistic (satisfaction, QoL) |
Medication use profile |
Foppa et al., 2016 |
Florianópolis, SC |
Public |
Quasi-experimental |
Medication therapy management |
Patients (51) |
Parkinson’s |
Clinical, humanistic (QoL) |
Adherence, DRP |
Garabeli et al., 2016Garabeli AA, Daher JB, Wiens A, Lenzi L, Pontarolo R. Quality of life perception of type 1 diabetic patients treated with insulin analogs and receiving medication review with follow-up in a public health care service from ponta Grossa-PR, Brazil. Braz J Pharm Sci . 2016;52(4):669-78.
|
Ponta Grossa, PR |
Public |
Cross-sectional |
Medication therapy management |
Patients (110) |
DM1 |
Clinical, humanistic (QoL) |
NA |
Loureiro et al., 2012 |
Fortaleza, CE |
Public |
Quasi-experimental |
Medication therapy management |
Patients (45) |
HIV/AIDS |
Clinical, humanistic (QoL) |
DRP, medication use profile |
Lyra Junior et al., 2007Lyra Jr DP, Kheir N, Abriata JP, da Rocha CE, dos Santos CB, Pelá IR. Impact of Pharmaceutical Care interventions in the identification and resolution of drug-related problems and on quality of life in a group of elderly outpatients in Ribeirão Preto (SP), Brazil. Ther Clin Risk Manag. 2007;3(6):989-98.
|
Ribeirão Preto, SP |
Public |
Quasi-experimental |
Medication therapy management |
Patients (30) |
Elderly |
Humanistic (QoL) |
DRP |
Marques et al., 2009 |
Alfenas, MG |
Public |
Quasi-experimental |
Medication therapy management |
Patients (74) |
No restriction |
NA |
Medication use profile, DRP |
Melo et al., 2017Melo DO, Molino CGC, Ribeiro E, Romano-Lieber NS. Capacitação e intervenções de técnicos de farmácia na dispensaçãvo de medicamentos em atenção primária à saúde. Cienc Saude Coletiva . 2017b;22(1):261-8.; Melo, Castro, 2017Melo DO, Castro LLC. Pharmacist’s contribution to the promotion of access and rational use of essential medicines in SUS. Cienc Saude Coletiva. 2017a;22(1):235-44.
|
São Paulo, SP |
Public |
Cross-sectional |
Medication therapy management, dispensing |
Pharmacist (1) and assistants (4) |
No restriction |
NA |
Counselling, follow-up process, components of dispensing |
Mendonça et al., 2016Mendonça SM, Melo AC, Pereira GC, dos Santos D, Grossi EB, Sousa M, et al. Clinical outcomes of medication therapy management services in primary health care. Braz J Pharm Sci . 2016;52(3):365-73.
|
Divinópolis, MG |
Public |
Descriptive (retrospective) |
Medication therapy management |
Patients (92) |
No restriction |
Clinical |
DRP, medication use profile |
Silva, Bazotte, 2011Silva G, Bazotte RB. Development and evaluation of a Pharmaceutical Care Program to reduce modifiable risk of chronic complications in Brazilian type 2 diabetic patients. Lat Am J Pharm . 2011;30(1):154-60.
|
Maringá, PR |
Private |
Quasi-experimental |
Medication therapy management |
Patients (51) |
DM2 |
Clinical |
NA |
Silva et al., 2013 |
Recife, PE |
Public |
Quasi-experimental |
Medication therapy management |
Patients (14) (pilot study) |
Elderly - dysj
|
Clinical |
Medication use profile, DRP, adherence |
Souza et al., 2009 |
Recife, PE |
Public |
Quasi-experimental |
Medication therapy management |
Patients (10) (pilot study) |
Hyp |
Clinical |
Medication use profile; DRP |
Detoni et al., 2017Detoni KB, Oliveira I V, Nascimento MMG, Caux TR, Alves MR, Ramalho-De-Oliveira D. Impact of a medication therapy management service on the clinical status of patients with chronic obstructive pulmonary disease. Int J Clin Pharm . 2017;39(1):95-103.
|
1 city, MG |
Public |
Cohort |
Medication therapy management |
Patients (83) |
COPDk
|
Clinical |
NA |
Santos et al., 2019 |
Lagoa Santa, MG |
Public |
Cross-sectional (phase I), quasi-experimental (phase II) |
Medication therapy management |
Patients (1,057) |
No restriction |
Clinical |
DRP, medication use profile |
Scarabelin et al., 2019Scarabelin A, Santana Dosea A, Aguiar PM, Storpirtis S. Pharmacist-patient communication in prostate cancer as a strategy to humanize health care: a qualitative study. J Patient Exp. 2019;6(2):150-6.
|
São Paulo, SP |
Public |
Qualitative |
Medication therapy management |
Patients (10) |
Prostate cancer |
NA |
Communication with the pharmacist, medication use profile |
Gomes et al., 2020Gomes LO, Teixeira MR, Rosa JA da, Foppa AA, Rover MRM, Farias MR. The benefits of a public pharmacist service in chronic hepattis C treatment: the real-life results of sofosbuvir-based therapy. Res Soc Adm Pharm. 2020;16(1):48-53.
|
Florianópolis, SC |
Public |
Cohort |
Medication therapy management |
Patients (240) |
Chronic hepatitis C (treatment with sofosbuvir) |
Clinical, humanistic (satisfaction) |
Medication use profile (with identification of adverse reactions and cure rate) |
Afonso et al., 2017 |
Igaratinga, MG |
Public |
Descriptive |
Dispensing |
Patients (198) |
No restriction |
Humanistic (satisfaction) |
NA |
Baldon et al., 2006 |
Curitiba, PR |
Private |
Cross-sectional |
Dispensing |
Pharmacists (101) |
Pregnancy |
NA |
Knowledge, therapeutic choice, use of EBP |
Bastos, Caetano, 2010 |
4 cities, RJ |
Private |
Qualitative |
Dispensing |
Pharmacists (15) |
No restriction |
Humanistic (perception, satisfaction) |
NA |
Bonadiman et al., 2018 |
8 cities, ES |
Public |
Descriptive (quantitative)
|
Dispensing |
Pharmacists (11) and patients (294) |
No restriction |
Humanistic (satisfaction, patients) |
Knowledge (pharmacists) |
Cassaro et al., 2016 |
9 cities, ES |
Public |
Cross-sectional |
Dispensing |
Patients (408) |
No restriction |
Humanistic (satisfaction)
|
NA |
Ferreira et al., 2016, 2018 |
Goiânia, GO |
Public |
Quasi-experimental |
Dispensing |
Patients (104) and pharmacists (2) |
No restriction |
Humanistic (satisfaction) |
Knowledge about treatment and adherence (patients), use of EPB, dispensing process, human resources (pharmacists) |
Lima et al., 2017Lima MG, Álvares J, Guerra Junior AA, Costa EA, Guibu IA, Soeiro OM, et al. Indicators related to the rational use of medicines and its associated factors. Rev Saude Publica . 2017;51(suppl 2):23S.; Soeiro et al., 2017Soeiro OM, Tavares NUL, Nascimento JM do, Guerra AA, Costa EA, Acurcio F de A, et al. Patient satisfaction with pharmaceutical services in Brazilian primary health care. Rev Saude Publica . 2017;51( suppl 2):21s.; Araújo et al., 2017Araújo P, Costa E, Guerra Junior A, Acurcio F, Guibu I, Álvares J, et al. Pharmaceutical care in Brazil’s primary health care. Rev Saude Publica. 2017;51:1s-11s.
|
PNAUMl (all Brazilian regions) |
Public |
Cross-sectional |
Clinical pharmacy services (dispensing, health education, drug therapy follow-up) |
Pharmacists (285) and patients (8,803) |
No restriction |
Humanistic (satisfaction) |
Infrastructure,. human resources, counselling, knowledge |
Luz et al., 2017 |
Divinópolis, MG |
Public |
Mixed (qualitative/ quantitative) |
Dispensing |
Pharmacists (4) and patients (69) |
No restriction |
Humanistic (satisfaction) |
Dispensing process, counselling, knowledge |
Obreli-Neto et al., 2013 |
Ourinhos, Assis, SP |
Private |
Cross-sectional |
Dispensing |
Pharmacists (41) |
OCm
|
NA |
Counselling, communication skills, dispensing process |
Oliveira et al., 2016 |
São Paulo, SP |
Public |
Cross-sectional |
Dispensing |
Pharmacists (4) |
No restriction |
NA |
Dispensing process, counselling |
Piccoli, Brito, Castilho, 2017 |
Niterói, RJ |
Public |
Cross-sectional |
Dispensing |
Pharmacists (6) and patients (154) |
HIV/AIDS |
NA |
Knowledge, dispensing process, counselling |
Volpato et al., 2005 |
Joinville, SC |
Private |
Cross-sectional |
Dispensing |
Pharmacists (70) and assistants (37) |
Sinusitis |
NA |
Counselling, dispensing process, therapeutic choice |
Zanella, Aguiar, Storpirtis, 2015 |
São Paulo, SP |
Public |
Cross-sectional |
Dispensing |
Pharmacists (7) and assistant (1) |
Mental disorders |
NA |
Dispensing process, counselling |
Ajalla, Castro, 2003Ajalla M, Castro L. Contribuição para melhoria da prática farmacêutica no atendimento de pacientes com queixas referentes a doenças sexualmente transmissíveis, em Campo Grande-MS. Rev Ciências Farm. 2003;24(2):121-30.
|
Campo Grande, MS |
Private |
Quasi-experimental |
Minor ailment management |
Pharmacists and assistants (185) |
STDn
|
NA |
Counselling, therapeutic choice |
Cadore et al., 1999Cadore L, Marc C, Berti C, Peukert C, Machado A. Pharmacy distribution of advice, symptomatic treatment and antimicrobial drugs to patients with cough. Braz J Infect Dis. 1999;3(5):180-3.
|
Porto Alegre, RS |
Private |
Cross-sectional |
Minor ailment management |
Pharmacists (20) and assistants (94) |
Cough |
NA |
Counselling, therapeutic choice |
Coulibaly et al., 2017 |
Alto Solimões, AM |
Private |
Qualitative |
Minor ailment management |
Pharmacists and assistants (11) |
Urethritis |
NA |
Counselling, therapeutic choice |
Galato et al., 2011Galato D, Alano GM, Trauthman SC, França TF. Pharmacy practice simulations: performance of senior pharmacy students at a University in southern Brazil. Pharm Pract. 2011;9(3):136-40.
|
SC |
Private |
Cross-sectional |
Minor ailment management |
Pharmacists (291) |
No restriction |
NA |
Counselling, therapeutic choice, knowledge |
Halila et al., 2015Halila GC, Junior EH, Otuki MF, Correr CJ. The practice of OTC counseling by community pharmacists in Parana, Brazil. Pharm Pract . 2015;13(4):1-8.; Hipólito Júnior et al., 2017Hipólito Júnior E, Halila GC, Christini W, Reis T, Guimarães MM, Guanaes LD, et al. Quality indicators of pharmacists’ services in community pharmacies in Paraná State, Brazil. Braz J Pharm Sci . 2017;53(1):1-9.
|
PR |
Private |
Cross-sectional |
Minor ailment management, pharmacy procedures# |
Pharmacists (533) |
No restriction |
NA |
Counselling, knowledge, infrastructure, use of EBP, identification of pharmacy procedures#, payment for PS |
Lima et al., 1989 |
Porto Alegre, RS |
Private |
Cross-sectional |
Minor ailment management |
Pharmacists (20) and assistants (20) |
Diarrhoea |
NA |
Knowledge, counselling, therapeutic choice |
Mesquita et al., 2013Mesquita AR, Sá DAB de O, Santos APAL, Neto A de A, Lyra-Júnior DP. Assessment of pharmacist’s recommendation of non-prescription medicines in Brazil: a simulated patient study. Int J Clin Pharm . 2013;35(4):647-55.
|
Aracaju, SE |
Private |
Cross-sectional |
Minor ailment management |
Pharmacists (25) |
Headache; diarrhoea |
NA |
Counselling, therapeutic choice, use of EBP, communication skills |
Naves et al., 2008 |
Brasília-DF, Taguatinga, GO |
Private |
Quasi-experimental |
Minor ailment management |
Pharmacists and assistants (78) |
STD |
NA |
Counselling, therapeutic choice, knowledge |
Neto, Galato, 2011Galato D, Alano GM, Trauthman SC, França TF. Pharmacy practice simulations: performance of senior pharmacy students at a University in southern Brazil. Pharm Pract. 2011;9(3):136-40. |
Tubarão, SC |
Private |
Qualitative |
Minor ailment management |
Pharmacists and assistants (20) |
STD |
NA |
Knowledge, counselling, therapeutic choice |
Rocha et al., 2014Rocha C, Bispo M, Alcantara T, Brito G, Vieira M, Lyra D. What do Brazilian community pharmacists know about self-medication for minor illnesses? A pilot study in the northeast of Brazil. J Appl Pharm Sci. 2014;4(5):12-20.
|
Aracaju, SE |
Private |
Mixed (qualitative/ quantitative)
|
Minor ailment management |
Pharmacists (35) (pilot study) |
No restriction |
NA |
Knowledge, use of EBP, counselling |
Rocha et al., 2015Rocha C, Bispo M, dos Santos A, Mesquita A, Brito G, Lyra D. Assessment of community pharmacists’ counseling practices with simulated patients who have minor illness. Simul Healthc J Soc Simul Healthc. 2015;10(4):227-38.
|
Aracaju, SE |
Private |
Cross-sectional |
Minor ailment management |
Pharmacists (40) |
Sinusitis; pregnancy |
NA |
Counselling, therapeutic choice, use of EPB, communication skills |
Santos et al., 2013Santos A, Mesquita A, Oliveira K, Lyra D. Assessment of community pharmacists´ counselling skills on headache management by using the simulated patient approach: a pilot study. Pharm Pract . 2013;11(1):3-7.
|
Aracaju, SE |
Private |
Cross-sectional |
Minor ailment management |
Pharmacists (24) |
Headache |
NA |
Counselling, therapeutic choice |
Gerenutti, Martinez, Bergamaschi, 2017Gerenutti M, Martinez AMV, Bergamaschi CC. The effectiveness of a pharmaceutical care model on adherence to antiretroviral therapy: A same-based cohort study in Brazil. Adv Pharm Bull. 2017;7(3):469-72.
|
Socoraba, SP |
Public |
Cohort |
Medication review |
Patients (130/229) |
HIV/AIDS |
Clinical |
Adherence |
Rigoni et al., 2015 |
Tubarão, SC |
Public |
Quasi-experimental |
Medication review |
Patients (40) |
Hyp |
Clinical, humanistic (satisfaction) |
Adherence, medication use profile |
Zatta, Perassolo, 2017 |
Novo Hamburgo, RS |
Private |
Quasi-experimental |
Medication review |
Patients (18) |
DM2 |
Clinical |
Adherence |
Dosea et al., 2017Dosea AS, Brito GC, Santos LM, Marques TC, Balisa-Rocha B, Pimentel D, et al. Establishment, implementation, and consolidation of clinical pharmacy services in community pharmacies: perceptions of a group of pharmacists. Qual Health Res. 2017;27(3):363-73.
|
3 cities, SE |
Public |
Qualitative |
Clinical pharmacy services (medication dispensing, medication review, medication therapy management, pharmacy procedures#) |
Pharmacists (11) |
No restriction |
NA |
Barriers and facilitators for implementation of the services |
Franceschet, Farias, 2005Franceschet I, Farias MR. Investigação do perfil dos farmacêuticos e das atividades desenvolvidas em farmácias do setor privado no município de Florianópolis, Santa Catarina, Brasil. Acta Farm Bonaer. 2005;24(4):590-7.
|
Florianópolis, SC |
Private |
Cross-sectional |
Clinical pharmacy services (dispensing, counselling) |
Pharmacists (90) |
No restriction |
NA |
Infra-structure, human resources use of EBP, counselling, dispensing process |
França Filho et al., 2008França Filho JB, Correr CJ, Rossignoli P, Melchiors AC, Fernández-Llimós F, Pontarolo R. Perfil dos farmacêuticos e farmácias em Santa Catarina: indicadores de estrutura e processo. Rev Bras Ciências Farm. 2008;44(1):105-13.
|
SC |
Private |
Cross-sectional |
Clinical pharmacy services, pharmacy procedures# |
Pharmacists (228) |
No restriction |
Humanistic (satisfaction) |
Infrastructure, human resources, knowledge of EBP |
Reis et al., 2015Reis TM, Rocha KSS, Barros IMC, Santos LMC, Paixão FP, Almeida FHO, et al. Pharmacists’ Skills in Conducting Clinical Services in Community Pharmacies in Urban Areas of Northeast Brazil. Lat Am J Pharm. 2015;34(4):725-31.
|
Aracaju, SE |
Private |
Cross-sectional |
Clinical pharmacy services (counselling, dispensing, medication therapy management) |
Pharmacists (39) |
No restriction |
NA |
Use of EBP, counselling, therapeutic choice, knowledge |
Santos Júnior et al., 2020Santos Júnior GA, Silva ROS, Onozato T, Silvestre CC, Rocha KSS, Araújo EM, et al. Implementation of clinical pharmacy services using problematization with Maguerez Arc: a quasi-experimental before-after study. J Eval Clin Pract . 2020;27(2):391-403.
|
Recife, PE |
Public |
Quasi-experimental |
Clinical pharmacy services (health education, dispensing, medication review, medication therapy management) |
Pharmacists (23) and patients (842 - medication therapy management) |
No restriction |
Clinical (patients) |
Physical structure and resources, knowledge (pharmacists), work process (i.e., systematisation, counselling, number and type of interventions, collaboration with healthcare team), DRP, medication use profile |
Aquino et al., 2019 |
Divinópolis, MG |
Public |
Quasi-experimental |
Clinical pharmacy services (intervention to pharmacotherapeutic empowerment) |
Patients (47) |
DM2 |
Clinical |
Adherence, self-care, self-efficacy, DRP |
Santos, Silva, Tavares, 2018 |
Itaim Paulista, SP |
Public |
Descriptive (retrospective) |
Clinical pharmacy services (consultation, health education) |
Patients (1,080) |
No restriction |
Clinical |
DRP, number of interventions |