Author and location |
Intervention duration |
Population |
Dose |
Type of associated treatment |
Intervention |
Outcomes |
He et al., 2011
17. He ZY, Shi CB, Wen H, Li FL, Wang BL, Wang J. Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. Cancer Invest. 2011;29(3):208-13.
USA
|
10, 20 and 30 days (depending on preoperative period) |
71 adult patients with colorectal CA |
Capsules with 360 mg curcumin 3x/day (1.08g/day curcumin) |
Radiotherapy or chemotherapy or combination of both |
Curcumin vs. control |
Body weight, TNF-α, P-53 protein expression, pro-apoptotic gene levels, and apoptosis death repressor and inducer proteins. |
Hejazi et al., 2016
18. Hejazi J, Rastmanesh R, Taleban FA, Molana SH, Hejazi E, Ehtejab G, et al. Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study. Nutr Cancer. 2016;68(1):77-85.
Iran
|
One week before start of radiotherapy until its conclusion (2 years) |
45 patients with prostate CA without metastasis. |
Capsules of 500 mg of BCM95, Biocurcumin 6x/day (3g/day of curcumin) |
Radiation therapy with 74 Gy dose |
Curcumin vs. Control with rice bran |
Body weight, PSA levels, SOD, catalase, GPx. |
Panahi et al., 2014
26. Panahi Y, Saadat A, Beiraghdar F, Sahebkar A. Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors: a randomized double-blind placebo-controlled trial. Phytother Res. 2014;28(10):1461-7.
Iran
|
8 weeks |
80 patients diagnosed with solid tumors |
3x 300 mg Meriva capsules per day (180 mg/day curcumin) |
Chemotherapy specific for each CA type |
Curcumin vs. control |
IL-6, IL-8, calcitonin gene, TNF-α, MCP-1, TGFβ, CRP and quality of life evaluation using the University of Washington scale (UW-QoL). |
Ryan et al., 2013
30. Ryan JL, Heckler CE, Ling M, Katz A, Williams JP, Pentland AP, et al. Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients. Radiat Res. 2013;180(1):34-43.
USA
|
During radiotherapy treatment (16-33 sessions) |
35 adult patients with breast CA |
4x 500 mg capsules of C3 Complex® 3x/day (2g/day of curcumin) |
Radiation therapy with a dose of 42.6-50.4 Gy, not associated with surgical or chemotherapy treatment |
Curcumin vs. Dicalcium phosphate control |
Severity score of RDS dermatitis and digital image of skin alterations and application of two self-report questionnaires: SI and SF-MPQ. |
Thomas et al., 2014
37. Thomas R, Williams M, Sharma H, Chaudry A, Bellamy P. A double-blind, placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer--the U.K. NCRN Pomi-T study. Prostate Cancer Prostatic Dis. 2014;17(2):180-6.
United Kingdom
|
6 months |
199 men with prostate cancer |
1 capsule with: powder of broccoli 100 mg, turmeric powder 100 mg, pomegranate 100 mg and green tea extract 100 mg, 3x/day (300 mg/day of curcumin) |
No information |
Curcumin, Broccoli, Pomegranate and Green Tea vs. Control containing the same volume and anti-caking agent, with 10 mg of watercress extract |
Serum levels of PSA |
Van Die et al., 2017
39. Van Die MDV, Williams SG, Emery J, Bone KM, Taylor JM, Lusk E, et al. A Placebo-Controlled Double-Blinded Randomized Pilot Study of Combination Phytotherapy in Biochemically Recurrent Prostate Cancer. Prostate . 2017;77(7):765-775.
Australia
|
12 weeks |
20 adult patients with prostate CA |
2 capsules, 2x/day of curcumin (400 mg/d); resveratrol (120 mg/d); green tea (400 mg/d); broccoli (8g/d). |
Surgery, radiotherapy or both |
Curcumin, Resveratrol, Green Tea and Broccoli vs. Control containing oats |
Serum levels of PSA |