Development of a mouse computational model for MCNPx based on Digimouse<b><sup>(r)</sup></b> images and dosimetric assays

Mendes, Bruno Melo; Almeida, Iassudara Garcia de; Trindade, Bruno Machado; Fonseca, Telma Cristina Ferreira; Campos, Tarcísio Passos Ribeiro de

doi:10.1590/s2175-97902017000116092

Bruno Melo Mendes

Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN), Belo Horizonte, MG, Brasil

Departamento de Engenharia Nuclear, DEN, Programa de Pós-Graduação em Ciências e Técnicas Nucleares, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, MG, Brasil

Iassudara Garcia de Almeida

Departamento de Engenharia Nuclear, DEN, Programa de Pós-Graduação em Ciências e Técnicas Nucleares, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, MG, Brasil

Bruno Machado Trindade

Departamento de Engenharia Nuclear, DEN, Programa de Pós-Graduação em Ciências e Técnicas Nucleares, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, MG, Brasil

Telma Cristina Ferreira Fonseca

Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN), Belo Horizonte, MG, Brasil

Tarcísio Passos Ribeiro de Campos

Departamento de Engenharia Nuclear, DEN, Programa de Pós-Graduação em Ciências e Técnicas Nucleares, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, MG, Brasil

*Correspondence: B. M. Mendes. Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN). Av. Antônio Carlos, 6627, Pampulha - 31270-901 Belo Horizonte, MG, Brazil. E-mail: bmm@cdtn.br or bmelom@yahoo.com.br

Study	Animal Weight (g)	Mouse Strain/sex	Voxel Dim. (mm³)	Matrix	Segment. Data	Phantom type	Tissue Composition and Density
DM_BRA^a	28	Nude/♂	0.25 x 0.25 x 0.50	152 x 396 x 42	CT/Cryos	voxel	ICRP (2009)
Xie, Zaidi (2013)^a	21 - 35^d	C57BL/6/♂	0.20 x 0.20 x 0.20	200 x 200 x 512	MR	voxel	-
Mauxion et al. (2013MAUXION, T.; BARBET, J.; SUHARD, J.; POUGET, J.P.; POIROT, M.; BARDIÈS, M. Improved realism of hybrid mouse models may not be sufficient to generate reference dosimetric data. Med. Phys., v.40, n.5, p.1-13, 2013.)^b	30	C57BL/6/♂	0.625 x 0.625 x 0.625 0.20 x 0.20 x 0.20	42 x 160 x 41 -	MR	voxel	Cristy, Eckerman, (1987CRISTY, M.; ECKERMAN, K.F. Specific absorbed fractions of energy at various ages from internal photon sources. I. Methods. Oak Ridge: Oak Ridge National Laboratory, 1987. 100 p.)
Zhang et al. (2012ZHANG, X; XIE, X; CHENG, J; NING, J; YUAN, Y; PAN, J; YANG, G. Organ dose conversion coefficients based on a voxel mouse model and MCNP code for external photon irradiation. Radiat. Prot. Dosim., v.148, n.1, p.9-19, 2012.)^a	28	Nude/♂	0.20 x 0.20 x 0.20	190 x 496 x 100	CT/Cryos	voxel	ICRU (1991)
Larsson et al. (2011LARSSON, E.; LJUNGBERG, M.; STRAND, S.E.; JÖNSSON, B.A. Monte Carlo calculations of absorbed doses in tumors using a modified MOBY mouse phantom for pre-clinical dosimetry studies. Acta Oncol., v.50, n.6, p.973-980, 2011.)^b	22, 28, 34	C57BL/6/♂	0.22 x 0.22 x 0.22 0.23 x 0.23 x 0.23 0.25 x 0.25 x 0.25	160 x 160 x 432	MR	voxel	ICRP (1974)
Mohammadi, Kinase (2011bMOHAMMADI, A.; KINASE, S. Influence of voxel size on specific absorbed fractions and S-values in a mouse voxel phantom. Radiat. Prot. Dosim., v.143, n.2/4, p.258-263, 2011b.)^a	28	Nude/♂	0.10 x 0.10 x 0.10 0.40 x 0.40 x 0.40	380 x 992 x 208 95 x 248 x 52	CT/Cryos	voxel	Cristy, Eckerman, (1987CRISTY, M.; ECKERMAN, K.F. Specific absorbed fractions of energy at various ages from internal photon sources. I. Methods. Oak Ridge: Oak Ridge National Laboratory, 1987. 100 p.)
Keenan et al. (2010KEENAN, M.A.; STABIN, M.G.; SEGARS, W.P.; FERNALD, M.J. RADAR realistic animal model series for dose assessment. J. Nucl. Med., v.51, n.3, p.471-476, 2010.)^b	25, 30, 35	C57BL/6/♂	0.625 x 0.625 x 0.625	-	MR	voxel	Cristy, Eckerman, (1987CRISTY, M.; ECKERMAN, K.F. Specific absorbed fractions of energy at various ages from internal photon sources. I. Methods. Oak Ridge: Oak Ridge National Laboratory, 1987. 100 p.)
Boutaleb (2009BOUTALEB, S.; POUGET, J.-P.; HINDORF, C.; PÈLEGRIN, A.; BARBET, J.; KOTZKI, P.-O.; BARDIÈS, M. Impact of mouse model on preclinical dosimetry in targeted radionuclide therapy. Proc. IEEE, v.97, p.2076-2085, 2009.)^a	28	Nude/♂	0.2 x 0.2 x 0.2	190 x 496 x 104	CT/Cryos	voxel	ICRU (1989)
Taschereau, Chatziioannou (2007TASCHEREAU, R.; CHATZIIOANNOU, A.F. Monte Carlo simulations of absorbed dose in a mouse phantom from 18-fluorine compounds. Med. Phys., v.34, n.3, p.1026-1036, 2007.)^b	33	C57BL/6/♂	0.40 x 0.40 x 0.40	80 x 80 x 270	MR	voxel	ICRU (1991)
Larsson et al. (2007LARSSON, E.; STRAND, S.E.; LJUNGBERG, M.; JÖNSSON, B.A. Mouse S-factors based on Monte Carlo simulations in the anatomical realistic moby phantom for internal dosimetry. Cancer Biother. Radio, v.22, n.3, p.38-442, 2007.)^b	33	C57BL/6/♂	0.25 x 0.25 x 0.25	128 x 128 x 432	MR	voxel	ICRP (1974)
Bitar et al. (2007BITAR, A.; LISBONA, A.; BARDIÈS, M. S-factor calculations for mouse models using Monte-Carlo simulations. Q. J. Nucl. Med. Mol. Imaging, v.51, n.4, p.343-351, 2007.)	30	Nude/♀	0.22 x 0.22 x 0.20	-	Cryos	voxel	ICRU (1989)
Stabin et al. (2006STABIN, M.G.; PETERSON, T.E.; HOLBURN, G.E.; EMMONS, M.A. Voxel-based mouse and rat models for internal dose calculations. J. Nucl. Med., v.47, n.4, p.655-659, 2006.)	27	Transgenic/♂	0.20 x 0.20 x 0.20	256 x 256 x 256	CT	voxel	-
Segars et al. (2004SEGARS, W.P.; TSUI, B.M.W.; FREY, E.C.; JOHNSON, G.A.; BERR, S.S. Development of a 4D digital mouse phantom for molecular imaging research. Mol. Imaging Biol., v.6, p.149-159, 2004.)^b	33	C57BL/6/♂	variable	Variable	MR	NURBS	-
Hindorf, Ljungberg, Strand (2004HINDORF, C.; LJUNGBERG, M.; STRAND, S.E. Evaluation of parameters influencing S values in mouse dosimetry. J. Nucl. Med., v.45, p.1960-1965, 2004.)^c	24	-	0.39 x 0.39 x 0.39	64 x 64 x 166	-	voxel	Cristy, Eckerman, (1987CRISTY, M.; ECKERMAN, K.F. Specific absorbed fractions of energy at various ages from internal photon sources. I. Methods. Oak Ridge: Oak Ridge National Laboratory, 1987. 100 p.)
Kolbert et al. (2003KOLBERT, K.S.; WATSON, T.; MATEI, C.; XU, S.; KOUTCHER, J.A.; SGOUROS, G. Murine S factors for liver, spleen, and kidney. J. Nucl. Med., v.44, n.5, p.784-791, 2003.)	25	Nude/♀	0.10 x 0.10 x 0.12	256 x 256 x 256	MR	voxel	-
Yoriyaz, Stabin (1997YORIYAZ, H.; STABIN, M. Electron and photon transport in a model of a 30 g mouse. J. Nucl. Med., v.38, Suppl., p.228, 1997.)	-	-	-	-	-	stylized	-
Hui (1994HUI, T.E.; FISHER, D.R.; KUHN, J.A.; WILLIAMS, L.E.; NOURIGAT, C.; HUTCHINSON, F.; BADGER, C.C. A mouse model for calculating cross-organ beta doses from yttrium-90-labeled immunoconjugates. Cancer, v.73, n.3, suppl., p.951-957, 1994.)^c	25	Nude/?	-	-	-	stylized	-

Organ/Tissue	Organ/Tissue mass (g) described in each study
Organ/Tissue	DM_BRA^a	Mohammadi, Kinase (2011a)^a	Zhang et al. (2012)^a	Boutaleb (2009BOUTALEB, S.; POUGET, J.-P.; HINDORF, C.; PÈLEGRIN, A.; BARBET, J.; KOTZKI, P.-O.; BARDIÈS, M. Impact of mouse model on preclinical dosimetry in targeted radionuclide therapy. Proc. IEEE, v.97, p.2076-2085, 2009.)^a	Taschereau, Chatziioannou (2007TASCHEREAU, R.; CHATZIIOANNOU, A.F. Monte Carlo simulations of absorbed dose in a mouse phantom from 18-fluorine compounds. Med. Phys., v.34, n.3, p.1026-1036, 2007.)^b	Keenan et al. (2010)^b	Mauxion et al. (2013)^b	Bitar et al. (2007)	Hindorf, Ljungberg, Strand (2004HINDORF, C.; LJUNGBERG, M.; STRAND, S.E. Evaluation of parameters influencing S values in mouse dosimetry. J. Nucl. Med., v.45, p.1960-1965, 2004.)^c	Stabin et al. (2006)
Adip. Tissue	2.379	-	-	-	-	-	-	1.859	-	-
Adrenals	0.005	0.006	0.004	-	-	-	-	0.011	-	-
Brain^f	0.350	0.385	0.442	-	0.635	0.570	0.606	0.516	-	-
Brown Fat	0.142	-	-	-	-	-	-	-	-	-
Eye	0.006	0.006	0.004	-	-	-	-	-	-	-
Gall Bladder	0.009	-	-	-	-	-	-	-	-	-
Hard. Gland	0.032	0.032	-	-	-	-	-	-	-	-
Heart	0.215	0.232	0.218	0.264	0.120^e	0.290	0.283	0.282	0.120	0.143
Intestine	2.311	-	-	-	1.820	2.830	2.941	2.927	-	0.952
Kidney	0.482	0.515	0.478	0.586	0.415	0.370	0.379	0.377	0.280	0.334
Liver	1.987	2.087	2.010	2.373	2.690	2.150	2.177	1.831	0.890	0.780
Lung	0.167	0.124	0.096	0.121	0.130	0.110	0.098	0.123	0.150	0.125
Muscle/Soft	12.254	-	17.117	-	-	-	-	-	-	-
Pancreas	0.047	0.047	0.041	-	0.440	0.380	0.390	0.090	-	-
Skeleton	2.311	1.656	1.820	-	2.573	2.610	3.336	1.074	-	-
Skin	2.228	-	3.841	-	6.910	-	-	-	-	-
Spinal Cord	0.099	0.048	-	-	-	-	-	0.112	0.190	-
Spleen	0.140	0.144	0.132	0.164	0.130	0.140	0.137	0.216	0.090	0.022
Stomach	0.245	0.235	0.254	0.264	0.085^d	0.069^e	0.070^e	0.438	-	0.298
Testes	0.159	0.156	0.136	1.76	0.400	0.200	0.188	-	0.250	0.141
Thyroid	-	-	-	-	0.015	0.020	0.017	0.005	0.020	-
U. Bladder	0.238	0.197	0.205	-	0.045^d	0.080	0.078	0.025	0.060	0.012
Total Body	25.7	23.4	26.9	27.0	32.8	29.8	30.2	30.7	24.0	-

Tissue/Organ	Organ volumes ratio			Ratio max/min Volume
Tissue/Organ	DM_BRA / Mohammadi, Kinase (2011a)	DM_BRA /Zhang et al. (2012ZHANG, X; XIE, X; CHENG, J; NING, J; YUAN, Y; PAN, J; YANG, G. Organ dose conversion coefficients based on a voxel mouse model and MCNP code for external photon irradiation. Radiat. Prot. Dosim., v.148, n.1, p.9-19, 2012.)	Mohammadi, Kinase (2011aMOHAMMADI, A.; KINASE, S. Monte Carlo simulations of photon specific absorbed fractions in a mouse voxel phantom. Prog. Nucl. Sci. Technol., v.1, p.126-129, 2011a.)/Zhang et al. (2012ZHANG, X; XIE, X; CHENG, J; NING, J; YUAN, Y; PAN, J; YANG, G. Organ dose conversion coefficients based on a voxel mouse model and MCNP code for external photon irradiation. Radiat. Prot. Dosim., v.148, n.1, p.9-19, 2012.)
Adrenals	0.838	1.255	1.499	1.499
Brain	0.900	0.784	0.872	1.275
Eye	0.997	1.496	1.501	1.501
Heart	0.919	0.996	1.084	1.084
Kidney	0.927	1.008	1.088	1.088
Liver	0.943	0.998	1.058	1.058
Lung	1.050	1.187	1.130	1.187
Pancreas	1.001	1.136	1.134	1.134
Skeleton	1.396	1.270	0.910	1.396
Spleen	0.970	1.082	1.115	1.115
Stomach	1.043	0.954	0.914	1.094
Testes	1.021	1.167	1.143	1.167
U. Bladder	1.204	1.152	0.956	1.204
Remaining Tissues	1.110	1.078	0.971	1.110

Photon Specific Absorbed Fractions - SAF (1/kg) - Source Organ = Heart
Energy (MeV)	Study	Skeleton	Heart	Bladder	Stomach	Spleen	Pancreas	Liver	Kidneys	Adrenal	Lungs
0.015	Mohammadi, Kinase (2011a)	6.8E+01	1.2E+03	1.9E-01	8.4E+00	2.8E+00	2.5E+00	3.8E+01	1.6E+00	4.8E+00	2.7E+02
	DM_BRA	4.6E+01	1.3E+03	2.4E-01	1.1E+01	3.1E+00	2.9E+00	3.5E+01	1.5E+00	4.5E+00	3.1E+02
	Ratio	0.67*	1.10	1.24*	1.33*	1.11	1.17	0.91	0.95	0.93	1.14*
0.1	Mohammadi, Kinase (2011a)	1.7E+00	3.1E+01	2.3E-01	1.0E+00	6.1E-01	5.7E-01	2.0E+00	4.6E-01	7.8E-01	7.5E+00
	DM_BRA	1.3E+00	3.1E+01	2.3E-01	1.3E+00	6.4E-01	6.3E-01	2.0E+00	4.8E-01	6.4E-01	8.5E+00
	Ratio	0.76*	1.01	0.99	1.25*	1.05	1.10	0.98	1.03	0.82	1.14*
0.5	Mohammadi, Kinase (2011a)	1.5E+00	3.6E+01	2.9E-01	1.3E+00	7.3E-01	6.9E-01	2.5E+00	5.9E-01	9.7E-01	9.5E+00
	DM_BRA	1.1E+00	3.6E+01	2.9E-01	1,50E+00	8,1E-01	7.2E-01	2.4E+00	6.0E-01	9.8E-01	1.1E+01
	Ratio	0.75*	1.00	1.00	1.15*	1.11	1.04	0.95	1.02	1.01	1.11
1	Mohammadi, Kinase (2011a)	1.4E+00	2.7E+01	2.9E-01	1.2E+00	7.2E-01	6.7E-01	2.4E+00	5.6E-01	8.1E-01	8.3E+00
	DM_BRA	1.0E+00	2.6E+01	2.8E-01	1.4E+00	7.9E-01	7.3E-01	2.2E+00	5.8E-01	8.3E-01	9.2E+00
	Ratio	0.74*	0.96	0.95	1.17*	1.10	1.08	0.93	1.03	1.03	1.10
4	Mohammadi, Kinase (2011a)	5.3E-01	4.4E+00	1.8E-01	7.7E-01	4.9E-01	4.9E-01	1.0E+00	3.9E-01	6.2E-01	1.8E+00
	DM_BRA	4.3E-01	4.1E+00	1.9E-01	8.2E-01	5.1E-01	4.9E-01	9.8E-01	3.8E-01	6.8E-01	1.9E+00
	Ratio	0.80*	0.94	1.03	1.07	1.05	1.01	0.98	0.99	1.10	1.03

[1] *Correspondence: B. M. Mendes. Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN). Av. Antônio Carlos, 6627, Pampulha - 31270-901 Belo Horizonte, MG, Brazil. E-mail: bmm@cdtn.br or bmelom@yahoo.com.br

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Development of a mouse computational model for MCNPx based on Digimouse^(r) images and dosimetric assays

ABSTRACT

Brasil

Brasil

Development of a mouse computational model for MCNPx based on Digimouse(r) images and dosimetric assays

ABSTRACT

Development of a mouse computational model for MCNPx based on Digimouse^(r) images and dosimetric assays