Serum (25(OH)D) |
25,620 |
1989 |
Geographical |
High leves is associated with with a three-fold decrease in colon cancer |
colon |
Garland et al., 1989Garland CF, Comstock GW, Garland FC, Helsing KJ, Shaw EK, Gorham ED. Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study. Lancet. 1989;2(8673): 1176-1178. https://doi.org/10.1016/s0140-6736(89)91789-3 https://doi.org/10.1016/s0140-6736(89)91...
|
Serum (25(OH)D) |
5 |
2007 |
Meta-analysis |
Circulating 25(OH)D levels ≥ 33 ng/mL reduce the risk of incidence of colorectal cancer |
colorectal |
Gorham et al., 2007Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, et al. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. Am J Prev Med. 2007; 32(3): 210-216. https://doi.org/10.1016/j.amepre.2006.11.004 https://doi.org/10.1016/j.amepre.2006.11...
|
UVB index |
Data for Caucasians age-adjusted of total U.S. population (period: 1950-1994) |
2006 |
Ecological study |
Solar UVB, through photosynthesis of vitamin D, is inversely associated with cancer mortality rates |
several cancers |
Grant and Garland, 2006Grant WB, Garland CF. The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates. Anticancer Res . 2006;26(4A):2687-2699. https://www.ncbi.nlm.nih.gov/pubmed/16886679 https://www.ncbi.nlm.nih.gov/pubmed/1688...
|
Serum (25(OH)D) |
24 (11340 participants included) |
2021 |
Meta-analisys |
Smokers present lower levels of circulating vitamin D |
smoking |
Yang et al., 2021Yang L, Zhao H, Liu K, Wang Y, Liu Q, Sun T, et al. Smoking behavior and circulating vitamin D levels in adults: A meta- analysis. Food Sci Nutr. 2021;9(10):5820-5832. https://doi.org/10.1002/fsn3.2488 https://doi.org/10.1002/fsn3.2488...
|
Ciculating 25(OH)D (plasma ou serum) |
1,065 cases and 1,066 controls |
2010 |
Case control studies |
Administration of vitamin D fail to diminish risk of upper gastrointestinal cancers |
esophageal and Gastric Cancer |
Abnet et al., 2010Abnet CC, Chen Y, Chow WH, Gao YT, Helzlsouer KJ, Le Marchand L, et al. Circulating 25-hydroxyvitamin D and risk of esophageal and gastric cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol. 2010;172(1):94-106. https://doi.org/10.1093/aje/kwq121 https://doi.org/10.1093/aje/kwq121...
|
questionnaire |
723 patients of gastric cancer and 2024 controls |
1994 |
Case-control studies |
Vitamin D levels is not associated with a protective role against gastric cancer |
gastric cancer |
La Vecchia et al., 1994La Vecchia C, Ferraroni M, D’Avanzo B, Decarli A, Franceschi S. Selected micronutrient intake and the risk of gastric cancer. Cancer Epidemiol Biomarkers Prev. 1994;3(5):393-398. https://www.ncbi.nlm.nih.gov/pubmed/7920206 https://www.ncbi.nlm.nih.gov/pubmed/7920...
|
questionnaire |
230 gastric cancer patients and 547 matched controls |
2009 |
Case-control studies |
No significant relationship between gastric cancer risk and vitamin D among other micronutrients |
gastric cancer |
Pelucchi et al., 2009Pelucchi C, Tramacere I, Bertuccio P, Tavani A, Negri E, La Vecchia C. Dietary intake of selected micronutrients and gastric cancer risk: an Italian case-control study. Ann Oncol. 2009;20(1):160-165. https://doi.org/10.1093/annonc/mdn536 https://doi.org/10.1093/annonc/mdn536...
|
semiquantitative food-frequency questionnaire |
46,771 men (the Health Professionals Follow-up Study), and 75,427 women (the Nurses' Health Study) |
2006 |
Prospective studies |
Potential role for vitamin D in prevention of pancreatic cancer. |
pancreatic cancer |
Skinner et al., 2006Skinner HG, Michaud DS, Giovannucci E, Willett WC, Colditz GA, Fuchs CS. Vitamin D intake and the risk for pancreatic cancer in two cohort studies. Cancer Epidemiol Biomarkers Prev . 2006;15(9):1688-1695. https://doi.org/10.1158/1055-9965.EPI-06-0206 https://doi.org/10.1158/1055-9965.EPI-06...
|
semi-quantitative food-frequency questionnaire. |
532 pancreatic cancer patients |
2011 |
Population-based case-control study |
Increased risk of pancreatic cancer associated with dietary intake of vitamin D and of calcium |
pancreatic cancer |
Zablotska et al., 2011Zablotska LB, Gong Z, Wang F, Holly EA, Bracci PM. Vitamin D, calcium, and retinol intake, and pancreatic cancer in a population-based case-control study in the San Francisco Bay area. Cancer Causes Control. 2011; 22(1): 91-100. https://doi.org/10.1007/s10552-010-9678-3 https://doi.org/10.1007/s10552-010-9678-...
|
Serum (25(OH)D) |
49 patients and 49 control |
2016 |
Retrospective case control study |
Lower vitamin D levelsin serum are associated with gastric adenocarcinoma |
gastric adenocarcinoma |
Vyas et al., 2016Vyas N, Companioni RC, Tiba M, Alkhawam H, Catalano C, Sogomonian R, et al. Association between serum vitamin D levels and gastric cancer: A retrospective chart analysis. World J Gastrointest Oncol. 2016;8(9):688-694. https://doi.org/10.4251/wjgo.v8.i9.688 https://doi.org/10.4251/wjgo.v8.i9.688...
|
Serum (25(OH)D) |
197 gastric carcinoma patients |
2012 |
Retrospective study |
Patients with high vitamin D levels group had a higher overall survival compared with the lowvitamin D levels group |
gastric adenocarcinoma |
Ren et al., 2012Ren C, Qiu MZ, Wang DS, Luo HY, Zhang DS, Wang ZQ, et al. Prognostic effects of 25-hydroxyvitamin D levels in gastric cancer. J Transl Med. 2012;10:16. https://doi.org/10.1186/1479-5876-10-16 https://doi.org/10.1186/1479-5876-10-16...
|
Serum (25(OH)D) |
545 esophageal squamous cell carcinoma and 353 gastric cardia adenocarcinoma patients |
2007 |
Prospective study |
No associations for gastric cardia or noncardia adenocarcinoma were found. However, in subjects with low vitamin D status, higher serum 25(OH)D concentrations were associated with significantly increased risk of ESCC in men, but not in women |
esophageal squamous cell carcinoma and gastric cardia and non cardia adenocarcinoma |
Chen et al., 2007Chen W, Dawsey SM, Qiao YL, Mark SD, Dong ZW, Taylor PR, et al. Prospective study of serum 25(OH)-vitamin D concentration and risk of oesophageal and gastric cancers. Br J Cancer. 2007;97(1):123-128. https://doi.org/10.1038/sj.bjc.6603834 https://doi.org/10.1038/sj.bjc.6603834...
|
Serum (25(OH)D) |
952 cases and 1,333 controls |
2010 |
Pooled nested case-control study (including ATBC Study, CLUE, the Cancer Prevention Study II Nutrition Cohort (CPS-II), the New York University Women's Health Study (NYU-WHS), the Multiethnic Cohort Study (MEC), the PLCO, and the Shanghai Women's and Men's Health Studies (SWHS and SMHS). |
No significant associations were observed for participants with lower 25(OH)D status. Higher levels of 25(OH)D was associated with a 2-fold increase in pancreatic cancer risk overall |
primary pancreatic adenocarcinomas |
Stolzenberg-Solomon et al., 2010Stolzenberg-Solomon RZ, Jacobs EJ, Arslan AA, Qi D, Patel AV, Helzlsouer KJ, et al. Circulating 25-hydroxyvitamin D and risk of pancreatic cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol . 2010;172(1):81-93. https://doi.org/10.1093/aje/kwq120 https://doi.org/10.1093/aje/kwq120...
|
plasma 25(OH)D |
69 studies included (17 cohort and 21 nested case-control, 30 case-control studies) |
2010 |
Meta-analysis |
A protective effect of vitamin D is observed in case-control studies when stratifying in premenopausal women, butnot significant association is found in cohort studies |
breast cancer |
Yin et al., 2010Yin L, Grandi N, Raum E, Haug U, Arndt V, Brenner H. Meta-analysis: serum vitamin D and breast cancer risk. Eur J Cancer. 2010;46(12):2196-2205. https://doi.org/10.1016/j.ejca.2010.03.037 https://doi.org/10.1016/j.ejca.2010.03.0...
|
plasma 25(OH)D |
12,204 |
2014 |
Prospective population-based study |
Not significant association between low levels of 25(OH)D and total or specific cancers |
several cancers |
Skaaby T et al., 2014Skaaby T, Husemoen LL, Thuesen BH, Pisinger C, Jorgensen T, Roswall N, et al. Prospective population-based study of the association between serum 25-hydroxyvitamin-D levels and the incidence of specific types of cancer. Cancer Epidemiol Biomarkers Prev . 2014;23(7):1220-1229. https://doi.org/10.1158/1055-9965.EPI-14-0007 https://doi.org/10.1158/1055-9965.EPI-14...
|
Serum (25(OH)D) |
1546 African American women and 1436 white women |
2002 |
National Health and Nutrition Examination Survey (1988-1994) |
Dark-skin populations present lower levels of 25(OH)D in plasma |
risk-factor |
Nesby-O'dell et al., 2002Nesby-O’Dell S, Scanlon KS, Cogswell ME, Gillespie C, Hollis BW, Looker AC, et al. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr. 2002;76(1):187-192. https://doi.org/10.1093/ajcn/76.1.187 https://doi.org/10.1093/ajcn/76.1.187...
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