Abstract
The aim of this study was to evaluate the impact of oral conditions and health-related quality of life (HRQoL) on oral health-related quality of life (OHRQoL) in children and adolescents with blood coagulation disorders and hemoglobinopathies (BCDH). The study was cross-sectional and included 61 individuals aged 2 to 18 years with BCDH. Exams for dental caries (dmft/DMFT index), oral hygiene (simplified oral hygiene index – OHI-S), and gingival health (modified gingival index – MGI) were performed. The pediatric quality of life inventory™ (PedsQL™) generic core scale and oral health scale were used to measure HRQoL and OHRQoL. Spearman’s correlation coefficient (ρ) and the Mann-Whitney test (α = 0.05) were conducted to assess the relationship between covariates and the PedsQL™ oral health scale. The mean PedsQL™ oral health scale score was 76.66 (SD = 21.36). Worse OHRQoL was correlated with poor oral hygiene (ρ = -0.383; p: 0.004), poor gingival health (ρ = -0.327; p = 0.014), and better HRQoL (ρ = 0.488; p < 0.001). Greater untreated dental caries experience was associated with worse OHRQoL (p = 0.009). Worse oral health status in children and adolescents with BCDH negatively impacts OHRQoL, and OHRQoL and quality of life analyzed from a generic perspective are positively correlated constructs in this population.
Blood Coagulation Disorders; Hemoglobinopathies; Quality of Life; Child; Adolescent; Oral Health
Introduction
Quality of life is a subjective attribute: it is the subject’s perception of their physical and emotional health, their social, economic, spiritual, and occupational relationships, and relies on the individual’s interpretation of what is good or bad.1 Thus, quality of life can be interpreted as one’s perception of reality in relation to what one wants or needs. Oral changes can affect the physical and psychosocial health of an individual, for example making it difficult for them to eat, leading to poor oral health-related quality of life (OHRQoL).2
Oral health problems can have a strong impact on the OHRQoL of individuals with systemic health conditions3,4 as their presence has been reported among those with blood coagulation disorders and hemoglobinopathies (BCDH).5,6
The characteristics of each inherited hematological disorder and its oral manifestations may contribute to the lower OHRQoL of these individuals. People with blood coagulation disorders, such as hemophilia and von Willebrand’s disease, have a higher risk of ‘spontaneous’ bleeding, especially in joints, muscles, and soft tissues. This risk is even higher in individuals with the most severe manifestations of the disorder7 and can be an important inhibitory factor for oral health self-care. Moreover, the patient’s concern about the bleeding risk in invasive dental procedures may prevent them from seeking dental care.8
In hemoglobinopathies, such as sickle cell disease, there is no increased risk for spontaneous bleeding. However, some authors believe that people with sickle cell disease are more susceptible to the development of oral manifestations.9
OHRQoL of children and adolescents with hematological disorders, as well as their families, is influenced by the clinical manifestations and the entire social and emotional context associated with these disorders.5,6In addition, these individuals live with barriers to accessing dental care, such as professional refusal when there is an increased risk of bleeding.10Little is known, however, about which oral condition, and with what intensity, affects OHRQoL of individuals with BCDH.
Although the Brazilian Public Health System (SUS) includes specialized care for this group, a better understanding of the impact of oral conditions on the quality of life of these individuals and their family nucleus can contribute to the improvement of existing care and treatment protocols. This includes seeking constant adaptation to the oral health demands from these groups. Therefore, the aim of this study was to evaluate and understand the impact of oral conditions and HRQoL on OHRQoL in children and adolescents with BCDH.
Methodology
Study design and setting
The research project was submitted to and approved by the Research Ethics Committees of the Division of Health Sciences of the Federal University of Paraná – UFPR (CAAE: 12901219.5.0000.0102) and of the Workers’ Hospital of the State Health Department of Paraná – SESA/PR (CAAE: 12901219.5.3001.5225), and followed the STROBE statement.11A cross-sectional study was carried out between August 2019 and February 2020 with children and adolescents aged between 2 and 18 years with BCDH, treated at the dental service of the Paraná Center of Hematology and Hemotherapy – Hemepar (Curitiba, Brazil), also including their parents or guardians.
The sample size was estimated through sample calculation for descriptive studies with continuous variables. The values obtained by Bendo et al.12 for a population of Brazilian children and adolescents aged 2 to 18 years were used as parameters for the PedsQL™ oral health scale (mean = 83.34; standard deviation = 16.63). In this study, a 95% confidence interval was chosen, with a desired accuracy of 5 points above and 5 points below the mean value (total range of 10 points), requiring a minimum sample of 43 individuals. However, due to the characteristics of the dental service at HEMEPAR and the possibility of not completing the questionnaires, all individuals treated during data collection were invited to participate in the research.
In the study, participants whose parents or legal guardians agreed to their participation in the study and signed the free informed consent form before the consultations were included.
Socioeconomic and clinical data
We designed a structured questionnaire to collect the socioeconomic and demographic data of the children and adolescents and their families: guardian’s schooling, marital status, guardian’s workplace, child’s sex, and guardian’s perception of the child’s oral health, and race/ethnicity. To obtain the clinical data, the children and adolescents were examined by four trained dentists (kappa ≥ 0.80), following the criteria adopted for each index. The dmft/DMFT (decayed, extracted/missing, and filled teeth) index13 was used for dental caries, the simplified oral hygiene index – OHI-S14 for oral hygiene, and the modified gingival index – MGI15 for gingival health.
The presence of untreated dental caries (UDC) was determined by the c/C component of the dmft/DMFT index. Dental caries experience was considered present in those individuals with a dmft/DMFT index equal to or greater than 1. Gingival health was categorized into ‘absence of inflammation’ (no bleeding = 0), ‘mild inflammation’ (not involving the entire marginal gingiva = 1; involving the entire marginal gingiva = 2), ‘moderate inflammation’ = 3, and ‘severe inflammation’ = 4. Oral hygiene was categorized as ‘good’ (no plaque = 0), ‘regular’ (plaque covering up to 1/3 of the tooth surface), and ‘poor’ (plaque covering more than 1/3, up to 2/3 of the tooth surface = 2; plaque covering more than 2/3 of the tooth surface = 3).
The other variables were divided into guardian’s schooling (‘8 years or less’ or ‘more than 8 years’ of formal education), marital status (‘married/in a common-law marriage’ or ‘others = single, widowed, separated’), guardian’s workplace (‘at home = household, retired’ or ‘away from home = formally employed, civil servant or unregistered worker’), child’s sex (‘female’ or ‘male’), and guardian’s perception of the child’s oral health (’positive = very good, good, regular’ or ‘negative = bad, very bad’).
Race/ethnicity was categorized as ‘white’, ‘brown’, ‘black’, ‘others’ = ‘East Asian’ or ‘indigenous’, or ‘undeclared’ according to IBGE’s (Brazilian Institute of Geography and Statistics) self-declaration of color or race.16
Reports of refusal of dental care (guardian’s report of a dentist’s refusal to see the child or adolescent due to their underlying disease) was divided into ‘yes’, when it happened, and ‘no’ when it never happened. Children’s and adolescents’ increased risk of gingival bleeding was classified as ‘yes = severe hemophilia A, moderate hemophilia A, severe hemophilia B, moderate hemophilia B, factor VII deficiency’ or ‘no = mild hemophilia A, mild hemophilia B, type I von Willebrand disease, sickle cell disease, thalassemia, spherocytosis’, and ‘individuals without a defined diagnosis’. The latter group was excluded from the association analyses. The hematological status of the individuals was determined through laboratory tests performed by the specialized medical team at HEMEPAR. We accessed these data through the institution’s electronic medical records. Per capita household income was considered numeric, as were all PedsQL™ scales.
Health-related quality of life and oral health-related quality of life
Health-related quality of life (HRQoL) was measured using the Pediatric Quality of Life Inventory™ - PedsQL™ generic core scale17 and oral health-related quality of life (OHRQoL) using the PedsQL™ oral health scale,18 translated into and validated for Brazilian Portuguese.12,19 For this study, we obtained a use license from Mapi Research Trust (study/protocol reference 176140).
PedsQL™ is a modular instrument to measure the quality of life of both healthy children and adolescents and those with acute or chronic health conditions. It is divided into age groups (2 to 4, 5 to 7, 8 to 12, and 13 to18 years) and presents two parallel instruments for each age group: one to the parents and one to the child or adolescent, except for children aged 2 to 4 years, in which case the instrument is only applied to the parents.12,17,18
The PedsQL™ generic core scale is composed of 23 items divided into four dimensions: physical functioning (eight items), emotional functioning (five items), social functioning (five items), and school functioning (five items).17The PedsQL™ oral health scale consisted of five items and only one dimension.18
All items in the instruments have five response options, recorded on a scale as follows: 0 (never), 1 (almost never), 2 (sometimes), 3 (often), and 4 (almost always), except for questionnaires aimed at children aged 5 to 7 years, in which case the scale was 0 (never), 2 (sometimes), and 4 (almost always). For this age group, a preparatory test provided with the instrument was applied. A separate page with the three-faced response options was used to help the children understand how they should respond.18,19 The response options were then reverse-scored and linearly transformed into a 0-100 scale (0 = 100, 1 = 75, 2 = 50, 3 = 25, and 4 = 0).
All items of the PedsQL™ instruments address the difficulty in participating, performing, or being present in some activity according to the perception of the individual or of their guardian. Thus, the closer the mean value is to 100, the less difficulty the respondent faces in the situations described by the instrument, and the better HRQoL or OHRQoL is. The closer the mean value is to zero, the greater the difficulty and the poorer HRQoL or OHRQoL.
Data consolidation and statistical analysis
We performed data statistical analysis using the SPSS software (IBM Corp.Released 2017.IBM SPSS Statistics for Windows, Version 25.0. Armonk, NY: IBM Corp.).
The PedsQL™ oral health scale values were not normally distributed (Kolmogorov-Smirnov test, p= 0.022). We used Spearman’s correlation coefficient (ρ) and the Mann-Whitney test to assess the relationship between the covariates and the PedsQL™ oral health scale. To interpret the magnitude of the correlations, we adopted the following classification: (ρ = 0.20 to 0.39 indicated a weak correlation, ρ = 0.40 to 0.69, a moderate correlation, ρ = 0.70 to 0.89, a strong correlation, and ρ > 0.89, a very strong correlation).
To obtain the total values of the PedsQL™ generic core and oral health scales, we summed the self-report values of children and adolescents aged 5 to 18 years (5 to 7, 8 to 12, and 13 to18 years) and the parental proxy-report values for children aged 2 to 4 years.
Results
During the study,, 69 children and adolescents between the ages of 2 and 18 years were admitted to HEMEPAR’s dental service. Eight guardians did not agree to participate in our study (response rate: 88.4%). Thus, the final sample included 61 children and adolescents and their guardians.
We present the socioeconomic and demographic characteristics of the children and adolescents and their guardians in Table 1. Most of the children and adolescents were male (68.9%), and their mean age was 8.4 years (SD = 4.7). Most of the guardians self-identified as white (59.0%) and 62.7% had attended school for more than 8 years. The median household income per capita was R$ 500.00 (Min: R$100.00; Max: R$ 5,000.00) and with an average of R$ 758.35 (SD = 814.28).
Most children and adolescents (69.5%) had dental caries experience (dmft/DMFT) ≥ 1) and 54.1% had at least one tooth with a UDC lesion (C/c component of DMFT or dmft). Only 21.4% of the children and adolescents had no signs of gingivitis. Oral hygiene was considered good in only 12.7% of the children and adolescents. It was not possible to perform the clinical examinations in two children because of difficulty in dental management (Table 2).
Out of the 61 children and adolescents in our study, 30 carried inherited blood coagulation disorders, mainly hemophilia A (n = 21). Twenty-nine children and adolescents had hemoglobinopathies, mainly sickle cell disease (n = 22). Two children/adolescents did not have a defined diagnosis (Table 3).
We observed an increased risk of bleeding due to underlying disease in 41% of the children and adolescents. Guardians reported bleeding gingiva for 30.0% of the children and adolescents. Most of the guardians considered the children’s and adolescents’ oral health to be positive (59.0%) (Table 3).
Table 4 presents the descriptive analysis of the dimensions of PedsQL™ generic core scales, with lower values for emotional aspects (mean: 68.54; SD: 22.71) and school problems (mean: 64.46; SD: 23.30). We obtained a total mean value of 76.66 and a standard deviation of 21.36 in the PedsQL™ oral health scale.
Descriptive analysis of the Brazilian version of PedsQL™ in its ‘generic core scale 4.0’ and ‘oral health scale 3.0’ (Hemepar, Curitiba, Brazil; n = 61).
Table 5 shows a moderate negative correlation between the PedsQL™ oral health scale and the child’s or adolescent’s age (ρ = -0.491; p < 0.001); a weak negative correlation between the PedsQL™ oral health scale oral hygiene (ρ = -0.383; p = 0.004) and gingival health (ρ = -0.327; p = 0.014); and a moderate positive correlation between the PedsQL™ oral health scale and the PedsQL™ generic core scales (ρ = 0.488; p < 0.001).
A greater presence of UDC was associated with worse OHRQoL (lower mean values on the PedsQL™ oral health scale). Guardians’ positive reporting of the oral health and lower perception of gingival bleeding in the children and adolescents were associated with better OHRQoL (higher mean values on the PedsQL™ oral health scale) (Table 6).
Discussion
Analyzing HRQoL and OHRQoL and the factors that may influence them in children and adolescents with BCDH is fundamental to understand their needs and formulate and apply public health policies. In this study, we observed that dental caries, gingival inflammation, and oral hygiene influenced the OHRQoL of children and adolescents with BCDH. We also observed a correlation between parents’ perception of their children’s oral health and gingival bleeding and the children’s and adolescents’ OHRQoL, as well as a correlation between HRQoL and OHRQoL.
OHRQoL has been studied in several populations of healthy individuals12,21 and in those with acute or chronic systemic involvement,3,4,22 especially in the last few decades. It has been observed that individuals with systemic conditions present a worse OHRQoL than healthy individuals.3,4,22 However, due to the wide variety of clinical manifestations of the various systemic conditions, it is plausible to consider that each condition affects the OHRQoL of carriers and their families in different ways and with different intensity.
Since BCDH have a low prevalence, it is essential to record the findings for various services and populations. However, few studies have assessed OHRQoL in individuals with hematologic changes.23-25 Due to the low prevalence of these conditions, the samples are often small in these studies, which makes interpretation and comparison of data more complex. In addition, the wide variety of instruments developed to assess OHRQoL also contributes to this challenge.26-28
The impact of oral conditions on the OHRQoL of children and adolescents has been assessed using PedsQL™ oral health scale in healthy individuals29 and in those with systemic diseases.3,4 The mean values of OHRQoL (from the PedsQL™ oral health scale) in children and adolescents without systemic conditions were higher than those found in our study.29 On the other hand, Cardoso et al.4 obtained OHRQoL (PedsQL™ oral health scale) values in adolescents with cerebral palsy that were very close to what we found for children and adolescents with BCDH. It is important to highlight the differences between the health problems presented, as individuals with cerebral palsy have different needs from patients with BCDH, such as changes in perception and cognitive deficit.30
Among the oral manifestations, dental caries is considered one of the main factors related to lower OHRQoL in children and adolescents, as they can lead to problems such as pain, infection, and systemic complications.31 Therefore, it has been shown to be an important factor in the decline of OHRQoL, both in healthy children and adolescents21,29and in those with systemic conditions such as cerebral palsy4 and chronic kidney disease.3 The results of this study confirm the association between dental caries and OHRQoL in children and adolescents with BCDH. This may be related to the fear or anxiety these individuals face due to the risk of bleeding during oral health care,32, financial barriers, or lack of dentists trained to treat them.33 This specificity can lead to the postponement of relatively simple dental procedures and thus cause the worsening of dental caries and significant pain.
In addition, in this study, gingival conditions and poorer oral hygiene of children and adolescents with BCDH were also correlated with OHRQoL. The literature shows that, in healthy individuals, episodes of gingival bleeding and the presence of periodontal disease29 influence OHRQoL. The same relationship has been observed in patients with cerebral palsy4 and chronic kidney disease.3
It is important to note that in individuals with BCDH, gingival health and oral hygiene have important specificities and are a cause for concern. Poor oral hygiene has been demonstrated in this population,34and it is likely that the fear of bleeding during oral hygiene contributes to this outcome.32 However, we should also consider that, in some situations, the opposite behavior can occur. Patients who are well oriented and aware that the increased risk of bleeding is associated with the accumulation of dental biofilm and not with the hematological alteration itself can establish an excellent standard of oral hygiene to avoid the accumulation of dental biofilm and, consequently, the bleeding.35
In addition to clinical conditions, in this study, parents’ reports of their children’s oral health conditions were associated with children’s and adolescents’ OHRQoL. It is likely that the systemic condition of these individuals and their need for increased health care36 will result in more attention to oral health and a greater likelihood that parents will notice oral manifestations. Cardoso et al.,4 for instance, observed that a positive perception of oral health was associated with better OHRQoL of individuals with cerebral palsy.
Children and adolescents with hematological alterations may have better oral health conditions, as they are inserted in specialized treatment centers that include health education actions from the first years of life.32,35 However, the high prevalence of oral diseases found in this study does not support this statement. It is likely that the differences found are also a result of the type of dental care provided to this population. Services with a great focus on prevention may have a greater positive impact on oral health levels than those more directed to curative treatment. On the other hand, it is suggested that children and adolescents with BCDH may neglect oral hygiene habits due to fear of the possibility of bleeding.34
In this study, we found a moderate positive correlation between the PedsQL generic core scale values and the PedsQL™ oral health scale, which confirms the close relationship between general health and oral health.37 Differences in the pattern of OHRQoL are expected depending on health conditions. Studies that also used the PedsQL™ generic core scales showed higher OHRQoL values in healthy groups12 than studies involving groups with systemic conditions such as cerebral palsy4 and chronic kidney disease.3
In our study, the social dimension of the PedsQL™ generic core scales was the least compromised. It is suggested that children and adolescents with BCDH have no difficulty socializing with other children and adolescents and participating in activities and games in their friendship circles. On the other hand, the emotional and school dimensions had the lowest mean values. The peculiar routine of a patient with blood disease can lead to challenges in the school environment, mainly due to physical deformities and limitations of functional abilities imposed by their systemic condition.38
Studies using questionnaires are subject to memory and information biases, but in the PedsQL™, the items do not refer to earlier than the previous month, which minimizes difficulties related to recalling events. Our study is the first to use the PedsQL™ oral health scale instrument to measure OHRQoL in children and adolescents with BCDH. The PedsQL™ oral health scale is very well suited for studying the OHRQoL of patients with low prevalence diseases, as it can be used over a wide age range with the same conceptual and construction logic. This facilitates the inclusion of many individuals, regardless of age and, consequently, the expansion of the studied group. The use of the PedsQL™ oral health scale to study the OHRQoL in groups with a wide age range, such as research in services aimed at the care of patients with chronic diseases, allows the use of a single instrument that covers the entire life cycle.18 Cross-sectional studies – such as ours – are not capable of raising causality; however, they suggest hypotheses that facilitate the design of more appropriate research to define causality.
Even if one of the advantages of the PedsQL™ oral health scale is the possibility of comparing the results of several groups, some precautions are still fundamental, especially regarding the age of the investigated group. Given that the instrument can be applied to children and adolescents aged 2 to 18 years and there is variation in the perception of OHRQoL as a function of age,17,18 this aspect should be considered in the comparative analysis of the studies. In addition, the external validity of our study should be considered very carefully.
Further studies are needed to deepen the understanding of how BCDH carriers perceive and behave regarding oral care. In addition, in order to correctly determine which factors are responsible for the observed changes in OHRQoL, studies with designs that have a more appropriate temporal range are needed.
Conclusion
We conclude that the oral conditions of children and adolescents with BCDH affect their quality of life. In addition, OHRQoL and the quality of life analyzed from a generic perspective are positively correlated constructs in this population.
References
-
1 Baiju RM, Peter E, Varghese NO, Sivaram R. Oral Health and Quality of Life: current Concepts. J Clin Diagn Res. 2017 Jun;11(6):ZE21-6. https://doi.org/10.7860/JCDR/2017/25866.10110
» https://doi.org/10.7860/JCDR/2017/25866.10110 -
2 World Health Organization. World Health Organization Quality of Life Assessment Gtroup. World Health Organization position paper. Soc Sci Med. 1995;41:1403-9. https://doi.org/10.1016/0277-9536 (95)00112-K
» https://doi.org/10.1016/0277-9536 (95)00112-K -
3 Silva TM, Alves LA, Garrido D, Watanabe A, Mendes FM, Ciamponi AL. Health and oral health-related quality of life of children and adolescents with chronic kidney disease: a cross-sectional study. Qual Life Res. 2019 Sep;28(9):2481-9. https://doi.org/10.1007/s11136-019-02196-8
» https://doi.org/10.1007/s11136-019-02196-8 -
4 Cardoso AM, Medeiros MM, Gomes LN, Martins ML, Padilha WW, Cavalcanti AL. Factors associated with health and oral health-related quality of life of children and adolescents with cerebral palsy. Spec Care Dentist. 2018 Jul;38(4):216-26. https://doi.org/10.1111/scd.12301
» https://doi.org/10.1111/scd.12301 -
5 Trindade GC, Viggiano LG, Brant ER, Lopes CA, Faria ML, Ribeiro PH, et al. Evaluation of quality of life in hemophilia patients using the WHOQOL-bref and Haemo-A-Qol questionnaires. Hematol Transfus Cell Ther. 2019;41(4):335-41. https://doi.org/10.1016/j.htct.2019.03.010
» https://doi.org/10.1016/j.htct.2019.03.010 -
6 Rizio AA, Bhor M, Lin X, McCausland KL, White MK, Paulose J, et al. The relationship between frequency and severity of vaso-occlusive crises and health-related quality of life and work productivity in adults with sickle cell disease. Qual Life Res. 2020 Jun;29(6):1533-47. https://doi.org/10.1007/s11136-019-02412-5
» https://doi.org/10.1007/s11136-019-02412-5 -
7 Srivastava A, Brewer AK, Mauser-Bunschoten EP, Key NS, Kitchen S, Llinas A, et al. Guidelines for the management of hemophilia. Haemophilia. 2013 Jan;19(1):e1-47. https://doi.org/10.1111/j.1365-2516.2012.02909.x
» https://doi.org/10.1111/j.1365-2516.2012.02909.x - 8 World Federation of Hemophilia. Report on the annual global survey 2018. Montreal: World Federation of Hemophilia; 2019.
-
9 Kakkar M, Holderle K, Sheth M, Arany S, Schiff L, Planerova A. Orofacial manifestation and dental management of sickle cell disease: a scoping review. Anemia. 2021 Oct;2021:5556708. https://doi.org/10.1155/2021/5556708
» https://doi.org/10.1155/2021/5556708 -
10 Frusca do Monte CM, Silva LT, Silva VC, Almeida GS, Lorenzato CS, Menezes JV, et al. Access to dental care for patients with inherited bleeding and hemoglobin disorders. Spec Care Dentist. 2022 Sep;42(5):509-15. https://doi.org/10.1111/scd.12701
» https://doi.org/10.1111/scd.12701 -
11 Malta M, Cardoso LO, Bastos FI, Magnanini MM, Silva CM. STROBE initiative: guidelines on reporting observational studies. Rev Saude Publica. 2010 Jun;44(3):559-65. https://doi.org/10.1590/S0034-89102010000300021
» https://doi.org/10.1590/S0034-89102010000300021 -
12 Bendo CB, Paiva SM, Viegas CM, Vale MP, Varni JW. The PedsQL™ Oral Health Scale: feasibility, reliability and validity of the Brazilian Portuguese version. Health Qual Life Outcomes. 2012 Apr;10(1):42. https://doi.org/10.1186/1477-7525-10-42
» https://doi.org/10.1186/1477-7525-10-42 - 13 World Heatlh Organization. Oral health surveys: basic methods - 5th edition. Geneve: World Heatlh Organization; 2013.
-
14 Greene JC, Vermillion JR. The simplified oral hygiene index. J Am Dent Assoc. 1964 Jan;68(1):7-13. https://doi.org/10.14219/jada.archive.1964.0034
» https://doi.org/10.14219/jada.archive.1964.0034 - 15 Lobene RR, Weatherford T, Ross NM, Lamm RA, Menaker L. A modified gingival index for use in clinical trials. Clin Prev Dent. 1986Jan-Feb;8(1):3-6.
- 16 Instituto Brasileiro de Geografia e Estatística. Pesquisa Nacional por Amostra de Domicílios Contínua. Rio de Janeiro: Instituto Brasileiro de Geografia e Estatística; 2014.; (Notas Metodológicas, v.1).
-
17 Varni JW, Seid M, Kurtin PS. PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. Med Care. 2001 Aug;39(8):800-12. https://doi.org/10.1097/00005650-200108000-00006
» https://doi.org/10.1097/00005650-200108000-00006 -
18 Steele M, Steele M, Varni J. Reliability and validity of the PedsQL™ oral health scale: measuring the relationship between child oral health and health-related quality of life. Child Health Care. 2009;38(3):228-44. https://doi.org/10.1080/02739610903038818
» https://doi.org/10.1080/02739610903038818 -
19 Klatchoian DA, Len CA, Terreri MT, Silva M, Itamoto C, Ciconelli RM, et al. Quality of life of children and adolescents from São Paulo: reliability and validity of the Brazilian version of the Pediatric Quality of Life Inventory version 4.0 Generic Core Scales. J Pediatr (Rio J). 2008;84(4):308-15. https://doi.org/10.2223/JPED.1788
» https://doi.org/10.2223/JPED.1788 - 20 Nora AD, Rodrigues CS, Rocha RO, Soares FZ, Braga MM, Lenzi TL. Is caries associated with negative impact on oral health-related quality of life of pre-school children? A systematic review and meta-analysis. Pediatr Dent. 2018 Nov;40(7):403-11.
-
21 Bohner L, Wiemann S, Jung S, Kleinheinz J, Hanisch M. [Oral health-related quality of life in rare diseases associated with oral symptoms, diagnostic delay, and sex]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2019 Nov;62(11):1406-11. German. https://doi.org/10.1007/s00103-019-03032-7
» https://doi.org/10.1007/s00103-019-03032-7 -
22 Fernandes ML, Kawachi I, Corrêa-Faria P, Pattusi MP, Paiva SM, Pordeus IA. Caries prevalence and impact on oral health-related quality of life in children with sickle cell disease: cross-sectional study. BMC Oral Health. 2015 Jun;15(1):68. https://doi.org/10.1186/s12903-015-0052-4
» https://doi.org/10.1186/s12903-015-0052-4 -
23 Yazicioglu I, Deveci C, Çiftçi V, Antmen B, Dogan MC. Parent's report on oral health-related quality of life of children with haemophilia. Haemophilia. 2019 Mar;25(2):229-35. https://doi.org/10.1111/hae.13678
» https://doi.org/10.1111/hae.13678 -
24 Ebeid FS, Khan NI. The adverse impact of thalassemia major on adolescents' oral health-related quality of life. J Pediatr Hematol Oncol. 2020 Jul;42(5):e345-51. https://doi.org/10.1097/MPH.0000000000001729
» https://doi.org/10.1097/MPH.0000000000001729 -
25 Huntington NL, Spetter D, Jones JA, Rich SE, Garcia RI, Spiro A 3rd. Development and validation of a measure of pediatric oral health-related quality of life: the POQL. J Public Health Dent. 2011;71(3):185-93. https://doi.org/10.1111/j.1752-7325.2011.00247.x
» https://doi.org/10.1111/j.1752-7325.2011.00247.x -
26 Slade GD. Derivation and validation of a short-form oral health impact profile. Community Dent Oral Epidemiol. 1997 Aug;25(4):284-90. https://doi.org/10.1111/j.1600-0528.1997.tb00941.x
» https://doi.org/10.1111/j.1600-0528.1997.tb00941.x - 27 McGrath C, Bedi R. An evaluation of a new measure of oral health related quality of life-OHQoL-UK(W). Community Dent Health. 2001 Sep;18(3):138-43.
-
28 Pakpour AH, Lin CY, Kumar S, Fridlund B, Jansson H. Predictors of oral health-related quality of life in Iranian adolescents: a prospective study. J Investig Clin Dent. 2018 Feb;9(1):e12264. https://doi.org/10.1111/jicd.12264
» https://doi.org/10.1111/jicd.12264 -
29 Mckinnon CT, Meehan EM, Harvey AR, Antolovich GC, Morgan PE. Prevalence and characteristics of pain in children and young adults with cerebral palsy: a systematic review. Dev Med Child Neurol. 2019 Mar;61(3):305-14. https://doi.org/10.1111/dmcn.14111
» https://doi.org/10.1111/dmcn.14111 -
30 Casamassimo PS, Thikkurissy S, Edelstein BL, Maiorini E. Beyond the dmft: the human and economic cost of early childhood caries. J Am Dent Assoc. 2009 Jun;140(6):650-7. https://doi.org/10.14219/jada.archive.2009.0250
» https://doi.org/10.14219/jada.archive.2009.0250 -
31 Jangra B, Goswami M. Assessment of dental caries experience and periodontal health status among children with haemophilia in new delhi, india - a case control study. Oral Health Prev Dent. 2017;15(2):131-7. https://doi.org/10.3290/j.ohpd.a37925
» https://doi.org/10.3290/j.ohpd.a37925 -
32 Schaffer R, Duong MT, Wachter B, Arana E, Frances D. Access to dental care for people with bleeding disorders: survey results of hemophilia treatment centers in the U.S. Spec Care Dentist. 2016 Nov;36(6):295-9. https://doi.org/10.1111/scd.12189
» https://doi.org/10.1111/scd.12189 - 33 Baskirt E, et al. Dental and periodontal health in children with hemophilia. J Coagul Disord. 2010;2(2):1-4.
-
34 Othman NA, Sockalingam SN, Mahyuddin A. Oral health status in children and adolescents with haemophilia. Haemophilia. 2015 Sep;21(5):605-11. https://doi.org/10.1111/hae.12657
» https://doi.org/10.1111/hae.12657 -
35 Peng J, Yang H, Fu G, Zhao X, Li X, Chen F. A study of the stressors and coping behaviors of parents of Chinese hemophilic children. J Child Health Care. 2017 Jun;21(2):212-21. https://doi.org/10.1177/1367493517705736
» https://doi.org/10.1177/1367493517705736 -
36 Alpert P. Oral health: the oral-systemic health connection. Home Health Care Manag Pract. 2016;29(1):56-9. https://doi.org/10.1177/1084822316651658
» https://doi.org/10.1177/1084822316651658 -
37 Zhu H, Meng Y, Tong P, Zhang S. Pathological mechanism of joint destruction in haemophilic arthropathy. Mol Biol Rep. 2021 Jan;48(1):969-74. https://doi.org/10.1007/s11033-020-06052-8
» https://doi.org/10.1007/s11033-020-06052-8
Publication Dates
-
Publication in this collection
24 June 2024 -
Date of issue
2024
History
-
Received
20 Oct 2022 -
Accepted
29 Jan 2024 -
Reviewed
04 Mar 2024