Rodrigues et al. 88. Rodrigues HM, Franzi SA. [Evaluation of pulp response in patients undergone radiation therapy for treatment of head and neck câncer]. Rev Bras Cir Cabeça Pescoço. 2007 Mar;36(1):23-6. Portuguese. |
Brazil |
Cross-sectional Retrospective Observational |
HNC patients submitted to RT. The mean age of patients was 54.4 years, ranging 40 to 74 years. |
RT Group (n = 12) |
- |
Fractional Dose totaling at least 45 Gy and max 71.2 Gy. |
Tumors are located in Tonsils, Tongue Edge, Soft Palate, Tongue Base, Tongue Belly, Anterior Pillar, Thyroid, Zygomatic Region, and Neck. |
Lower, Superior Incisors and Canines |
Control Group: 103 teeth |
The analysis was performed at the end of the RT, with an average time of 4.3 months. |
Cold Sensitivity Test |
In the RT Group, 28.6% of the teeth did not respond to the Thermal Test, while 71.4% showed a positive response. In the Control Group, the rate was 11% for negative responses and 89% for positive responses, with a statistically significant difference. |
- |
Control Group (n = 12) |
RT Group: 91 teeth |
Kataoka et al. 1111. Kataoka SH, Setzer FC, Gondim-Junior E, Pessoa OF, Gavini G, Caldeira CL. Pulp vitality in patients with intraoral and oropharyngeal malignant tumors undergoing radiation therapy assessed by pulse oximetry. J Endod. 2011 Sep;37(9):1197-200. https://doi.org/10.1016/j.joen.2011.05.038 https://doi.org/10.1016/j.joen.2011.05.0...
|
Brazil |
Cohort |
Patients with cancer in the oronasopharyngeal region. The mean age was 47.2 years, ranging 35 to 55 years. |
RT Group |
- |
Fractional Doses totaling 60 to 70 Gy |
Intraoral Malignant Neoplasms in the oronasopharynx |
Incisors Lower, Superior |
22 upper and 18 lower |
Before the beginning of RT (TP1), during RT (between doses of 30 and 35 Gy) (TP2), at the end of RT (total doses between 60 and 70 Gy) (TP3), and 4 to 5 months after completing treatment (TP4). |
Pulse Oximetry and Pulpal Cold Sensitivity Test |
SpO2 values in the study were 93% (TP1), 83% (TP2), 77% (TP3) and 85% (TP4). There were responses from TP1 to the Thermal Test (100%); however, only 9 continued to respond positively in TP2 (23%). No response was recorded in TP3 (0%) and TP4 (0%). |
There was a recovery of SpO2 from oxygen in TP4, 4 to 5 months after the end of RT. |
Prospective |
(n = 20) |
Kataoka et al. 2424. Kataoka SH, Setzer FC, Fregnani ER, Pessoa OF, Gondim E Jr, Caldeira CL. Effects of 3-dimensional conformal or intensity-modulated radiotherapy on dental pulp sensitivity during and after the treatment of oral or oropharyngeal malignancies. J Endod. 2012 Feb;38(2):148-52. https://doi.org/10.1016/j.joen.2011.09.022 https://doi.org/10.1016/j.joen.2011.09.0...
|
Brazil |
Cohort |
Patients with oral and oropharynx cancer. The average age was 47.2 years, ranging 35 to 55 years. |
IMRT Group (n = 12) |
IMRT |
Fractionated doses totaling 60 to 70 Gy |
Oropharyngeal Cancer, Mouth Cancer. |
Incisors Lower, Superior |
22 upper and 18 lower |
Before the beginning of RT (TP1), during RT (between doses of 30 and 35 Gy) (TP2), at the end of RT (total doses between 60 and 70 Gy) (TP3), and after 4 to 5 months of completion of treatment (TP4). |
Cold Sensitivity Test |
All 40 teeth showed positive responses to the TP1 Sensitivity Test (40/40, 100%). Nine teeth continued to respond positively in TP2 (9/40, 22.5%): 3 of 16 (18.8%) in the 3D-RT and 6 of 24 (25.0%) in the IMRT group. |
During the RT, there was a decrease in the number of teeth that responded to the Sensitivity Test after doses greater than 30 to 35 Gy of radiation. There was no difference among the RT techniques |
Prospective |
3D RT Group (n = 8) |
3D RT |
Garg et al. 2020. Garg H, Grewal MS, Rawat S, Suhag A, Sood PB, Grewal S, et al. Dental pulp status of posterior teeth in patients with oral and oropharyngeal cancer treated with concurrent chemoradiotherapy. J Endod. 2015 Nov;41(11):1830-3. https://doi.org/10.1016/j.joen.2015.08.006 https://doi.org/10.1016/j.joen.2015.08.0...
|
India |
Cohort |
Patients with HNC treated with chemoradiotherapy. The mean age was 52.5. |
Group Chemotherapy (n = 20). |
IMRT |
Fractionated doses totaling 60 to 70 Gy |
Oral or Oropharyngeal Cancer |
Posterior |
42 upper and 42 lower |
Before the beginning of RT (TP1), during RT (between doses of 30 and 35 Gy) (TP2), at the end of RT (total doses between 60 and 70 Gy) (TP3), and after 4 to 5 months of completion of treatment (TP4). |
Cold Sensitivity Test |
All teeth showed positive responses to the thermal sensitivity test in PT1 (100%) and 25 (29%) in PT2. No teeth responded to the PT3 and PT4 sensitivity test (0%). |
During the RT, there was a decrease in the number of teeth that responded to the sensitivity test after doses greater than 30 to 35 Gy of radiation. There was no difference among the RT techniques. |
Prospective |
Kataoka et al. 1919. Kataoka SH, Setzer FC, Gondim-Junior E, Fregnani ER, Moraes CJ, Pessoa OF, et al. Late effects of head and neck radiotherapy on pulp vitality assessed by pulse oximetry. J Endod. 2016 Jun;42(6):886-9. https://doi.org/10.1016/j.joen.2016.02.016 https://doi.org/10.1016/j.joen.2016.02.0...
|
Brazil |
Cross-sectional Retrospective Observational |
Patients with HNC submitted to RT. The average age of the patients was in 49.4 years for the RT Group, and 49.6 years for the control group was |
RT Group (n = 90) |
IMRT |
Fractional doses of 2 Gy daily, totaling 66 to 70 Gy |
Cancer in Oropharynx, Oral Cavity, Nasopharynx, and Hypopharynx. |
Upper Incisors, Upper Canines, Lower Incisors, Lower Canines. |
Total of 1386 teeth, being 693 teeth in the RT Group (240 maxillary incisors, 104 maxillary canines, 240 mandibular incisors, and 109 mandibular canines), and there were 693 (235 maxillary incisors in the control group, 115 maxillary canines, 225 mandibular incisors, and 118 lower canines). |
The patients were rated from 4 to 6 years after the end of RT. |
Pulse Oximetry and Cold Sensitivity Test |
The mean SpO2% recorded in the RT group was 92.7%, and 92.6% in the Control Group. All the teeth showed positive responses to the Sensitivity Test. |
There was a recovery of SpO2 levels 4 to 6 years after radiotherapy treatment. |
Control Group (n = 90) |
Gupta et al. 2222. Gupta N, Grewal MS, Gairola M, Grewal S, Ahlawat P. Dental Pulp Status of Posterior Teeth in Patients with Oral and Oropharyngeal Cancer Treated with Radiotherapy: 1-year Follow-up. J Endod. 2018 Apr;44(4):549-54. https://doi.org/10.1016/j.joen.2017.12.017 https://doi.org/10.1016/j.joen.2017.12.0...
|
India |
Cohort |
Patients with oral or oropharyngeal cancer. The mean age was 58.5 years. |
RT Group (n = 79). |
IMRT |
Fractionated doses totaling 60 to 70 Gy. |
Oral or pharyngeal cancer |
Posterior |
288 |
Patients were evaluated before RT (TP1), at the end of radiotherapy treatment (TP2), 4 months after the end of RT (TP3), 6 months after RT (TP4), and finally 1 year after the end of RT (TP5). |
Cold Sensitivity Test |
All teeth (100%) responded to cold tests at TP1. In TP2 and TP3, only 23 (7.98%) and 6 (2.08%) teeth gave a positive response to the cold test. In TP4 and TP5, none of the teeth responded to the cold test. |
There was no recovery of response levels, as sensitivity progressively decreased. |
Prospective |
Daveshwar et al. 2525. Daveshwar SR, Kapoor SV, Daveshwar MR. A clinical study determining pulp vitality in oropharyngeal cancer patients undergoing radiotherapy using diagnostic tool-pulse oximetry. Curr Health Sci J. 2021;47(1):5-9. https://doi.org/10.12865/CHSJ.47.01.01 https://doi.org/10.12865/CHSJ.47.01.01...
|
India |
Cohort |
Patients with oropharyngeal cancer. The mean age was 46.04. |
RT Group (n = 25) |
- |
Fractionated doses totaling 60 to 70 Gy |
Oropharyngeal Cancer |
1st Lower Premolar |
25 tooth |
Before initiation of RT (TP 1), immediately after RT (TP 2), and six months after RT (TP 3) |
Pulse Oximetry |
The mean SpO2 before RT (TP1) was 93.60, 75.12 after RT (TP2), and 81.04 six months later (TP3). |
There was partial recovery at the end of the 6 months after completing RT (TP3); however, the values are still lower than those in TP1. |
Prospective |