2007 |
Hu et al.1414. Hu S, Loo JA, Wong DT. Human saliva proteome analysis. Ann N Y Acad Sci. 2007 Mar;1098(1):323-9. https://doi.org/10.1196/annals.1384.015
https://doi.org/10.1196/annals.1384.015...
|
Detection of oral cancer and Sjögren syndrome |
Slight advantage over serum in detection |
2007 |
Giusti et al.6060. Giusti L, Baldini C, Bazzichi L, Ciregia F, Tonazzini I, Mascia G, et al. Proteome analysis of whole saliva: a new tool for rheumatic diseases—the example of Sjögren's syndrome. Proteomics. 2007 May;7(10):1634-43. https://doi.org/10.1002/pmic.200600783
https://doi.org/10.1002/pmic.200600783...
|
Detection of Sjögren syndrome |
Proteomics may be useful in diagnosis of connective tissue disorders |
2008 |
Hu et al.6161. Hu S, Arellano M, Boontheung P, Wang J, Zhou H, Jiang J, et al. Salivary proteomics for oral cancer biomarker discovery. Clin Cancer Res. 2008 Oct;14(19):6246-52. https://doi.org/10.1158/1078-0432.CCR-07-5037
https://doi.org/10.1158/1078-0432.CCR-07...
|
Detection of oral cancer |
Promising approach to searching for oral cancer biomarkers |
2009 |
Wu et al.6262. Wu ZZ, Wang JG, Zhang XL. Diagnostic model of saliva protein finger print analysis of patients with gastric cancer. World J Gastroenterol. 2009 Feb;15(7):865-70. https://doi.org/10.3748/wjg.15.865
https://doi.org/10.3748/wjg.15.865...
|
Detection of gastric cancer |
Promising approach for early clinical diagnosis of gastric cancer |
2009 |
Wu et al.6363. Wu Y, Shu R, Luo LJ, Ge LH, Xie YF. Initial comparison of proteomic profiles of whole unstimulated saliva obtained from generalized aggressive periodontitis patients and healthy control subjects. J Periodontal Res. 2009 Oct;44(5):636-44. https://doi.org/10.1111/j.1600-0765.2008.01172.x
https://doi.org/10.1111/j.1600-0765.2008...
|
Profile of generalized aggressive periodontitis |
Proteome analysis may contribute to understanding the etiology of aggressive periodontitis |
2009 |
Yan et al.6464. Yan W, Apweiler R, Balgley BM, Boontheung P, Bundy JL, Cargile BJ, et al. Systematic comparison of the human saliva and plasma proteomes. Proteomics Clin Appl. 2009 Jan;3(1):116-34. https://doi.org/10.1002/prca.200800140
https://doi.org/10.1002/prca.200800140...
|
Systematic comparison of the human saliva and plasma proteomes |
High similarity between saliva and plasma proteomes |
2010 |
de Jong et al.6565. de Jong EP, Xie H, Onsongo G, Stone MD, Chen XB, Kooren JA, et al. Quantitative proteomics reveals myosin and actin as promising saliva biomarkers for distinguishing pre-malignant and malignant oral lesions. PLoS One. 2010 Jun;5(6):e11148. https://doi.org/10.1371/journal.pone.0011148
https://doi.org/10.1371/journal.pone.001...
|
Detection of oral cancer |
Promising detection method for oral cancer |
2010 |
Wu et al.6666. Wu JY, Yi C, Chung HR, Wang DJ, Chang WC, Lee SY, et al. Potential biomarkers in saliva for oral squamous cell carcinoma. Oral Oncol. 2010 Apr;46(4):226-31. https://doi.org/10.1016/j.oraloncology.2010.01.007
https://doi.org/10.1016/j.oraloncology.2...
|
Potential biomarkers in saliva for oral squamous cell carcinoma |
Salivary screening can be the best option for primary screening of high-risk cases of oral cancer |
2010 |
Gonçalves et al.6767. Gonçalves LDR, Soares MR, Nogueira FCS, Garcia C, Camisasca DR, Domont G, et al. Comparative proteomic analysis of whole saliva from chronic periodontitis patients. J Proteomics. 2010 May;73(7):1334-41. https://doi.org/10.1016/j.jprot.2010.02.018
https://doi.org/10.1016/j.jprot.2010.02....
|
Analysis of chronic periodontitis patients |
Proteome analysis may contribute to the improvement of periodontal diagnosis |
2011 |
Castagnola et al.5959. Castagnola M, Picciotti PM, Messana I, Fanali C, Fiorita A, Cabras T, et al. Potential applications of human saliva as diagnostic fluid. Acta Otorhinolaryngol Ital. 2011 Dec;31(6):347-57.
|
Potential applications of human saliva as a diagnostic fluid |
A proteomic analysis approach may be useful in diagnosis of head and neck cancers, breast and gastric cancers, salivary gland function and disease, Sjögren syndrome, systemic sclerosis, dental and gingival pathology, systemic, psychiatric, and neurological diseases |
2011 |
Xiao et al.6868. Xiao H, Wong DT. Proteomics and its applications for biomarker discovery in human saliva. Bioinformation. 2011 Jan;5(7):294-6. https://doi.org/10.6026/97320630005294
https://doi.org/10.6026/97320630005294...
|
Biomarkers discovery in human saliva |
Found salivary proteomic biomarkers for oral cancer, Sjögren syndrome and breast cancer |
2012 |
Xiao et al.6969. Xiao H, Zhang L, Zhou H, Lee JM, Garon EB, Wong DTW. Proteomic analysis of human saliva from lung cancer patients using two-dimensional difference gel electrophoresis and mass spectrometry. Mol Cell Proteomics. 2012;11(2):M111.012112. https://doi.org/10.1074/mcp.M111.012112
https://doi.org/10.1074/mcp.M111.012112...
|
Detection of lung cancer |
Proteomic biomarkers are present in human saliva when people develop lung cancer |
2012 |
Ambatipudi et al.7070. Ambatipudi KS, Swatkoski S, Moresco JJ, Tu PG, Coca A, Anolik JH, et al. Quantitative proteomics of parotid saliva in primary Sjögren's syndrome. Proteomics. 2012 Oct;12(19-20):3113-20. https://doi.org/10.1002/pmic.201200208
https://doi.org/10.1002/pmic.201200208...
|
Detection of primary Sjögren syndrome |
Proteome analysis improved and provided early diagnosis of primary Sjögren syndrome |
2013 |
Amado et al.4040. Amado FM, Ferreira RP, Vitorino R. One decade of salivary proteomics: current approaches and outstanding challenges. Clin Biochem. 2013 Apr;46(6):506-17. https://doi.org/10.1016/j.clinbiochem.2012.10.024
https://doi.org/10.1016/j.clinbiochem.20...
|
Overview of the major achievements in saliva proteomics |
Identified protein markers for chronic periodontitis, gingivitis, head and neck squamous cell carcinoma, non-invasive breast cancer, rheumatoid arthritis, periodontitis, aggressive periodontitis, dental caries, Sjögren syndrome, lung cancer, type 2 diabetes in the elderly, orthodontic treatment, pre-malignant and malignant lesions, gastric cancer, periodontitis with obesity, oral leukoplakia, type 1 diabetes, |
2013 |
Martins et al.7171. Martins C, Buczynski AK, Maia LC, Siqueira WL, Castro GF. Salivary proteins as a biomarker for dental caries: a systematic review. J Dent. 2013 Jan;41(1):2-8. https://doi.org/10.1016/j.jdent.2012.10.015
https://doi.org/10.1016/j.jdent.2012.10....
|
Systematic review of salivary proteins as biomarkers for dental caries |
Lack of sufficient evidence to establish salivary proteins as a biomarker for this disease |
2017 |
Zuanazzi et al.7272. Zuanazzi D, Arts EJ, Jorge PK, Mulyar Y, Gibson R, Xiao Y, et al. Postnatal Identification of Zika Virus Peptides from Saliva. J Dent Res. 2017 Sep;96(10):1078-84. https://doi.org/10.1177/0022034517723325
https://doi.org/10.1177/0022034517723325...
|
Postnatal identification of Zika virus peptides from saliva |
Possibility of non-invasive sampling of saliva for subsequent large-scale screening for Zika virus infection |