Abstract
The objective of this study was to evaluate the effects of different protocols combining cyanocobalamin and butaphosphan on metabolic markers and milk production by Holstein cows postpartum. We used 154 multiparous cows housed in a free-stall system and divided into five groups, using the number of lactations and the probable date of calving as randomization criteria. The animals received intramuscular applications of a 100 mg/mL butaphosphan and 0.05 mg/mL cyanocobalamin combination. The treatment was delivered in a volume of 1 mL for every 20 Kg of body weight on varying treatment days as follows: treatment 1 (T1), on delivery day (day 0) (n=36); T2, days 0 and 3 (n = 31); T3: days 0 and 7 (n = 30); T4: days 0, 3 and 7 (n = 28). The control group (CG) received saline solution on days 0, 3 and 7 (n = 29). Blood samples were collected for metabolite evaluation on days 0, 7, 21 and 30. Milk production was recorded once a week for up to 98 lactation days. T4 elicited higher average milk production (25.87±0.34 kg/day; P < 0.001) than all other groups. Administering butaphosphan and cyanocobalamin on days 0, 3 and 7 postpartum increased milk production and improved energy and liver metabolism in the animals.
Keywords:
negative energy balance; organic phosphorus; B12 vitamin