Schittek et al.,(99 Schittek GA, Zoidl P, Eichinger M, Orlob S, Simonis H, Rief M, et al. Adsorption therapy in critically ill with septic shock and acute kidney injury: a retrospective and prospective cohort study. Ann Intensive Care. 2020;10(1):154.) Germany |
Retrospective control group and prospective intervention group |
Patients in severe septic shock with sepsis-associated acute kidney injury |
Retrospective controls with septic shock (rising noradrenaline dose above 20µg/minute) with sepsis associated acute kidney injury in CVVHDF |
No information |
No information overall. Survivors, approximately one cartridge per patient was utilized as the median (IQR 1 - 2) for 35.5 hours (17 - 47) |
76.70 |
Hawchar et al.,(1010 Hawchar F, László I, Öveges N, Trásy D, Ondrik Z, Molnar Z. Extracorporeal cytokine adsorption in septic shock: a proof of concept randomized, controlled pilot study. J Crit Care. 2019;49:172-8.), Hungary |
RCT |
Septic shock |
Patients with septic shock of medical origin, on mechanical ventilation, norepinephrine > 10µg/minute, procalcitonin > 3ng/mL without the need for renal replacement therapy |
Started within 24 hours after ICU admission |
24 hours |
0 |
Rugg et al.,(1111 Rugg C, Klose R, Hornung R, Innerhofer N, Bachler M, Schmid S, et al. Hemoadsorption with CytoSorb in septic shock reduces catecholamine requirements and in-hospital mortality: a single-center retrospective ‘Genetic’ Matched Analysis. Biomedicines. 2020;8(12):539.) Austria |
Propensity-score-weighted retrospective study |
Primary or secondary sepsis |
Matched controls were treated for septic shock and required RRT but did not receive CytoSorb® therapy. A generalized propensity score and Mahalanobis distance matching method (‘genetic’ matching) was applied |
Initiation of CytoSorb therapy varied from 0.5 to 719 hours after ICU admission, but most patients received treatment within the first days |
1 - 6 x 24 hours without interruption |
21.40 |
Akil et al.,(1818 Akil A, Ziegeler S, Reichelt J, Rehers S, Abdalla O, Semik M, et al. Combined use of CytoSorb and ECMO in patients with severe pneumogenic sepsis. Thorac Cardiovasc Surg. 2021;69(3):246-51.) Germany |
Cohort historic control |
Pneumogenic sepsis and ECMO |
Historical cohort. Patients with pneumogenic septic shock accompanying acute respiratory failure, invasive hemodynamic monitoring, and demand for norepinephrine 0.3µg/minute; elevated lactate concentrations 2.0mmol/L; and procalcitonin serum level 1ng/mL were eligible |
Within 6 hours after admission to our ICU |
Minimum 2 x 24 hours without interruption |
0 |
Brouwer et al.,(1919 Brouwer WP, Duran S, Kuijper M, Ince C. Hemoadsorption with CytoSorb shows a decreased observed versus expected 28-day all-cause mortality in ICU patients with septic shock: a propensity-score-weighted retrospective study. Crit Care. 2019;23(1):317.) The Netherlands |
Propensity-score weighted retrospective study |
Septic shock |
Patients with septic shock treated with CRRT without CytoSorb®. Stabilized inverse probability treatment weight was applied |
CytoSorb® was initiated at the discretion of the treating intensive care physician |
24 hours, mean duration of 2.34 ± 0.16 days |
52.20 |
Schädler et al.,(2020 Schädler D, Pausch C, Heise D, Meier-Hellmann A, Brederlau J, Weiler N, et al. The effect of a novel extracorporeal cytokine hemoadsorption device on IL-6 elimination in septic patients: A randomized controlled trial. PLoS One. 2017;12(10):e0187015.) Germany |
RCT |
Severe sepsis or septic shock within 72 hours of ARDS or acute lung injury |
Mechanically ventilated patients with severe sepsis or septic shock in the setting of acute lung injury or acute respiratory distress syndrome established within the last 72 hours |
Enrollment within 72 hours of diagnosis of sepsis with ARDS/ALI |
Maximum 7 x 6 hours 24 hours apart |
36 |