Highlights
-
The serum levels of sTREM-1 and IP-10 were increased in children with mycoplasma.
-
Serum levels of sTREM-1 and IP-10 were positively correlated with the severity of the disease.
-
sTREM-1 combined with IP-10 has an important value in the diagnosis of children with MPP.
Abstract
Objective
Early diagnosis of Severity Mycoplasma Pneumoniae Pneumonia (SMPP) has been a worldwide concern in clinical practice. Two cytokines, soluble Triggering Receptor Expressed on Myeloid cells (sTREM-1) and Interferon-Inducible Protein-10 (IP-10), were proved to be implicated in bacterial infection diseases. However, the diagnostic value of sTREM-1 and IP-10 in MPP was poorly known. This study aimed to investigate the diagnostic value of sTREM-1 and IP-10 for SMPP.
Methods
In this prospective study, the authors enrolled 44 children with MPP, along with their clinical information. Blood samples were collected, and cytokine levels of sTREM-1 and IP-10 were detected with ELISA assay.
Results
Serum levels of sTREM-1 and IP-10 were positively correlated with the severity of MPP. In addition, sTREM-1 and IP-10 have significant potential in the diagnosis of SMPP with an Area Under Curve (AUC) of 0.8564 (p-value = 0.0001, 95% CI 0.7461 to 0.9668) and 0.8086 (p-value = 0.0002, 95% CI 0.6918 to 0.9254) respectively. Notably, the combined diagnostic value of sTREM-1 and IP-10 is up to 0.911 in children with SMPP (p-value < 0.001, 95% CI 0.830 to 0.993).
Conclusions
Serum cytokine levels of sTREM-1 and IP-10 have a great potential diagnostic value in children with SMPP.
Keywords
sTREM-1; IP-10; Severe mycoplasma pneumoniae pneumonia; Diagnostic value
Thumbnail
Thumbnail
Thumbnail
