Changes of GH-IGFs and its relationship with growth retardation in children with bronchial asthma

Li, Li; Qiu, Lihua; Xia, Junchao; Xiao, Yichun; Zhao, Li; Wang, Haiyan

doi:10.1016/j.clinsp.2024.100385

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Sumário

Original articles • Clinics 79 • 2024 • https://doi.org/10.1016/j.clinsp.2024.100385 copy

Changes of GH-IGFs and its relationship with growth retardation in children with bronchial asthma

Authorship SCIMAGO INSTITUTIONS RANKINGS

Highlights

GH-IGFs-related parameters.
GH-IGFs-related parameters in patients with different severity of bronchial asthma.
Correlation analysis of GH-IGFs-related parameters and severity of bronchial asthma.
GH-IGFs-related parameters in patients with or without growth retardation.
Diagnostic value of GH-IGFs-related indicators in growth retardation.
Logistic regression analysis of GH-IGFs-related indicators and growth retardation.

Abstract

Objective

To explore the relationship between Growth Hormone Insulin-like Growth Factors (GH-IGFs) and growth retardation in children with bronchial asthma.

Methods

112 children with bronchial asthma and 50 healthy children were studied. Serum GH, IGF-1, and Insulin-like Growth Factor Binding Protein 3 (IGFBP3) were assessed by ELISA. GH-IGFs-related parameters were compared, and the correlation between the parameters and bronchial asthma severity was analyzed. The bronchial asthma group was divided into the growth retardation group and non-growth retardation group to analyze the diagnostic value of GH-IGFs in growth retardation and the relationship between GH-IGFs and growth retardation.

Results

GH, IGF-1, and IGFBP3 in the bronchial asthma group were lower. GH, IGF-1, and IGFBP3 levels were decreased with the severity of bronchial asthma. GH, IGF-1, and IGFBP3 in the growth retardation group were lower than those in the non-growth retardation group. The AUC of GH-IGFs combined detection was higher than that of GH and IGFBP3 alone detection. GH < 9.27 μg/L and IGF-1 < 179.53 mmoL/L were risk factors for growth retardation in patients with bronchial asthma.

Conclusion

GH-IGFs-related parameters have diagnostic value for growth retardation in children, and decreased levels of GH and IGF-1 are risk factors for growth retardation in children.

Keywords
Children Bronchial Asthma; Growth Hormone; Insulin-like Growth Factor Ⅰ; Insulin-like Growth Factor Binding Protein 3; Growth Retardation

Items	Bronchial asthma group(n = 112)	Control group(n = 50)	χ2/t	p
Gender
Male	62	31	0.131	0.716
Female	50	19
Age (years)	8.92 ± 1.17	8.76 ± 1.21	0.672	0.503
Course of disease (days)	10.52 ± 2.03	10.98 ± 2.15	1.1	0.274
Maternal height (cm)	161.29 ± 4.67	162.02 ± 4.73	0.777	0.439
Paternal height (cm)	172.85 ± 5.06	172.79 ± 5.11	0.059	0.953
Family history of asthma	13	5	0.09	0.764

Parameters	Cut-off value	AUC	SE	95 %CI
GH	9.27 μg/L	0.811^a a p < 0.05.	0.049	0.715ཞ0.907
IGF-1	179.53 mmoL/L	0.905	0.028	0.850ཞ0.960
IGFBP3	8.12 mmoL/L	0.677^a a p < 0.05.	0.06	0.559ཞ0.795
Combined		0.941	0.021	0.899∼0.982

Parameters	β	SE	waldχ²	OR	95 %CI	p
GH	−0.614	0.197	9.714	0.541	0.368ཞ0.796	0.002
IGF-1	−0.118	0.028	17.76	0.889	0.841ཞ0.939	<0.001
IGFBP3	−0.228	0.227	1.009	0.796	0.510ཞ1.242	0.316
Constant	2.35	0.513	20.985	10.486	3.836ཞ28.659	<0.001

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E-mail: clinics@hc.fm.usp.br

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[1] Declaration of competing interest

The authors declare no conflicts of interest.