Abstract
Objectives:
To retrospectively investigate the impact of pre-treatment Extracellular Volume Fraction (ECV) measured by Computed Tomography (CT) on the response of primary lesions to preoperative chemotherapy in abdominal neuroblastoma.
Methods:
A total of seventy-five patients with abdominal neuroblastoma were retrospectively included in the study. The regions of interest for the primary lesion and aorta were determined on unenhanced and equilibrium phase CT images before treatment, and their average CT values were measured. Based on patient hematocrit and average CT values, the ECV was calculated. The correlation between ECV and the reduction in primary lesion volume was examined. A receiver operating characteristic curve was generated to assess the predictive performance of ECV for a very good partial response of the primary lesion.
Results:
There was a negative correlation between primary lesion volume reduction and ECV (r = -0.351, p = 0.002), and primary lesions with very good partial response had lower ECV (p < 0.001). The area under the curve for ECV in predicting the very good partial response of primary lesion was 0.742 (p < 0.001), with a 95 % Confidence Interval of 0.628 to 0.836. The optimal cut-off value was 0.28, and the sensitivity and specificity were 62.07 % and 84.78 %, respectively.
Conclusions:
The measurement of pre-treatment ECV on CT images demonstrates a significant correlation with the response of the primary lesion to preoperative chemotherapy in abdominal neuroblastoma.
Keywords:
Neuroblastoma; Extracellular Volume Fraction; Preoperative Chemotherapy; Computed Tomography
HIGHLIGHTS
ECV correlates with the response of the primary lesion to preoperative chemotherapy in abdominal neuroblastoma.
Lower ECV in neuroblastoma is associated with a greater reduction in primary lesion volume after chemotherapy.
ECV may serve as a new imaging biomarker for predicting chemotherapy efficacy in neuroblastoma.
Thumbnail
Thumbnail
Thumbnail
Thumbnail
