Radiological fracture healing time |
251 (3 studies) (3131. Peichl P, Holzer LA, Maier R, Holzer G. Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women. J Bone Joint Surg Am. 2011;93(17):1583-7, https://doi.org/10.2106/JBJS.J.01379. https://doi.org/10.2106/JBJS.J.01379...
,3333. Aspenberg P, Genant HK, Johansson T, Nino AJ, See K, Krohn K, et al. Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J Bone Miner Res. 2010;25(2):404-14, https://doi.org/10.1359/jbmr.090731. https://doi.org/10.1359/jbmr.090731...
,3434. Huang TW, Chuang PY, Lin SJ, Lee CY, Huang KC, Shih HN, et al. Teriparatide Improves Fracture Healing and Early Functional Recovery in Treatment of Osteoporotic Intertrochanteric Fractures. Medicine. 2016;95(19):e3626, https://doi.org/10.1097/MD.0000000000003626. https://doi.org/10.1097/MD.0000000000003...
) |
⊕⊕⊕⊝ MODERATE due to risk of bias |
|
|
The mean radiological fracture healing time in the intervention groups was 3.06 lower (6.12 lower to 0.01 higher) |
Radiological fracture healing rate |
256 (4 studies) (2929. Bhandari M, Jin L, See K, Burge R, Gilchrist N, Witvrouw R, et al. Does Teriparatide Improve Femoral Neck Fracture Healing: Results From A Randomized Placebo-controlled Trial. Clin Orthop Relat Res. 2016;474(5):1234-44, https://doi.org/10.1007/s11999-015-4669-z. https://doi.org/10.1007/s11999-015-4669-...
30. Kanakaris NK, West RM, Giannoudis PV. Enhancement of hip fracture healing in the elderly: Evidence deriving from a pilot randomized trial. Injury. 2015;46(8):1425-8, https://doi.org/10.1016/j.injury.2015.06.033. https://doi.org/10.1016/j.injury.2015.06...
31. Peichl P, Holzer LA, Maier R, Holzer G. Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women. J Bone Joint Surg Am. 2011;93(17):1583-7, https://doi.org/10.2106/JBJS.J.01379. https://doi.org/10.2106/JBJS.J.01379...
-3232. Almirol EA, Chi LY, Khurana B, Hurwitz S, Bluman EM, Chiodo C, et al. Short-term effects of teriparatide versus placebo on bone biomarkers, structure, and fracture healing in women with lower-extremity stress fractures: A pilot study. J Clin Transl Endocrinol. 2016;5:7-14, https://doi.org/10.1016/j.jcte.2016.05.004. https://doi.org/10.1016/j.jcte.2016.05.0...
) |
⊕⊕⊕⊝ MODERATE due to inconsistency |
OR 7.84 (0.47 to 130.27) |
514 per 1000 |
378 more per 1000 (from 182 fewer to 479 more) |
Fracture pain degree |
320 (5 studies) (3131. Peichl P, Holzer LA, Maier R, Holzer G. Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women. J Bone Joint Surg Am. 2011;93(17):1583-7, https://doi.org/10.2106/JBJS.J.01379. https://doi.org/10.2106/JBJS.J.01379...
,3333. Aspenberg P, Genant HK, Johansson T, Nino AJ, See K, Krohn K, et al. Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J Bone Miner Res. 2010;25(2):404-14, https://doi.org/10.1359/jbmr.090731. https://doi.org/10.1359/jbmr.090731...
,3434. Huang TW, Chuang PY, Lin SJ, Lee CY, Huang KC, Shih HN, et al. Teriparatide Improves Fracture Healing and Early Functional Recovery in Treatment of Osteoporotic Intertrochanteric Fractures. Medicine. 2016;95(19):e3626, https://doi.org/10.1097/MD.0000000000003626. https://doi.org/10.1097/MD.0000000000003...
,3636. Chesser TJ, Fox R, Harding K, Halliday R, Barnfield S, Willett K, et al. The administration of intermittent parathyroid hormone affects functional recovery from trochanteric fractured neck of femur: a randomised prospective mixed method pilot study. Bone Joint J. 2016;98-B(6):840-5, https://doi.org/10.1302/0301-620X.98B6.36794. https://doi.org/10.1302/0301-620X.98B6.3...
,3737. Johansson T. PTH 1-34 (teriparatide) may not improve healing in proximal humerus fractures. A randomized, controlled study of 40 patients. Acta Orthop. 2016;87(1):79-82, https://doi.org/10.3109/17453674.2015.1073050. https://doi.org/10.3109/17453674.2015.10...
) |
⊕⊕⊕⊝ MODERATE due to risk of bias |
|
|
The mean fracture pain degree in the intervention groups was 1.42 standard deviations lower (2.55 to 0.29 lower) |
Fracture pain degree, PRWE scores |
57 (1 study) (3333. Aspenberg P, Genant HK, Johansson T, Nino AJ, See K, Krohn K, et al. Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J Bone Miner Res. 2010;25(2):404-14, https://doi.org/10.1359/jbmr.090731. https://doi.org/10.1359/jbmr.090731...
) |
⊕⊕⊕⊕ HIGH |
|
|
The mean fracture pain degree, PRWE scores in the intervention groups, was 2.53 standard deviations lower (3.24 to 1.82 lower) |
Fracture pain degree, VAS scores |
263 (4 studies) (3131. Peichl P, Holzer LA, Maier R, Holzer G. Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women. J Bone Joint Surg Am. 2011;93(17):1583-7, https://doi.org/10.2106/JBJS.J.01379. https://doi.org/10.2106/JBJS.J.01379...
,3433. Aspenberg P, Genant HK, Johansson T, Nino AJ, See K, Krohn K, et al. Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J Bone Miner Res. 2010;25(2):404-14, https://doi.org/10.1359/jbmr.090731. https://doi.org/10.1359/jbmr.090731...
,3636. Chesser TJ, Fox R, Harding K, Halliday R, Barnfield S, Willett K, et al. The administration of intermittent parathyroid hormone affects functional recovery from trochanteric fractured neck of femur: a randomised prospective mixed method pilot study. Bone Joint J. 2016;98-B(6):840-5, https://doi.org/10.1302/0301-620X.98B6.36794. https://doi.org/10.1302/0301-620X.98B6.3...
,3737. Johansson T. PTH 1-34 (teriparatide) may not improve healing in proximal humerus fractures. A randomized, controlled study of 40 patients. Acta Orthop. 2016;87(1):79-82, https://doi.org/10.3109/17453674.2015.1073050. https://doi.org/10.3109/17453674.2015.10...
) |
⊕⊕⊕⊝ MODERATE due to risk of bias |
|
|
The mean fracture pain degree, VAS scores in the intervention groups, was 1.15 standard deviations lower (2.36 lower to 0.07 higher) |
Functional outcome |
178 (4 studies) (3030. Kanakaris NK, West RM, Giannoudis PV. Enhancement of hip fracture healing in the elderly: Evidence deriving from a pilot randomized trial. Injury. 2015;46(8):1425-8, https://doi.org/10.1016/j.injury.2015.06.033. https://doi.org/10.1016/j.injury.2015.06...
,3131. Peichl P, Holzer LA, Maier R, Holzer G. Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women. J Bone Joint Surg Am. 2011;93(17):1583-7, https://doi.org/10.2106/JBJS.J.01379. https://doi.org/10.2106/JBJS.J.01379...
,3333. Aspenberg P, Genant HK, Johansson T, Nino AJ, See K, Krohn K, et al. Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J Bone Miner Res. 2010;25(2):404-14, https://doi.org/10.1359/jbmr.090731. https://doi.org/10.1359/jbmr.090731...
,3737. Johansson T. PTH 1-34 (teriparatide) may not improve healing in proximal humerus fractures. A randomized, controlled study of 40 patients. Acta Orthop. 2016;87(1):79-82, https://doi.org/10.3109/17453674.2015.1073050. https://doi.org/10.3109/17453674.2015.10...
) |
⊕⊕⊕⊝ MODERATE due to risk of bias |
|
|
The mean functional outcome in the intervention groups was 1.28 standard deviations lower (2.33 to 0.24 lower) |
Functional outcome, 4 weeks |
58 (2 studies) (3030. Kanakaris NK, West RM, Giannoudis PV. Enhancement of hip fracture healing in the elderly: Evidence deriving from a pilot randomized trial. Injury. 2015;46(8):1425-8, https://doi.org/10.1016/j.injury.2015.06.033. https://doi.org/10.1016/j.injury.2015.06...
,3737. Johansson T. PTH 1-34 (teriparatide) may not improve healing in proximal humerus fractures. A randomized, controlled study of 40 patients. Acta Orthop. 2016;87(1):79-82, https://doi.org/10.3109/17453674.2015.1073050. https://doi.org/10.3109/17453674.2015.10...
) |
⊕⊕⊕⊝ MODERATE due to risk of bias |
|
|
The mean functional outcome, 4 weeks in the intervention groups, was 0.42 standard deviations lower (0.97 lower to 0.13 higher) |
Functional outcome, over 4 weeks |
120 (2 studies) (3131. Peichl P, Holzer LA, Maier R, Holzer G. Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women. J Bone Joint Surg Am. 2011;93(17):1583-7, https://doi.org/10.2106/JBJS.J.01379. https://doi.org/10.2106/JBJS.J.01379...
,3333. Aspenberg P, Genant HK, Johansson T, Nino AJ, See K, Krohn K, et al. Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J Bone Miner Res. 2010;25(2):404-14, https://doi.org/10.1359/jbmr.090731. https://doi.org/10.1359/jbmr.090731...
) |
⊕⊕⊕⊕ HIGH |
|
|
The mean functional outcome, over 4 weeks in the intervention groups, was 2.17 standard deviations lower (2.89 to 1.45 lower) |