Correlation of serum Klotho, fetuin-A, and MGP levels with coronary artery calcification in maintenance hemodialysis patients

ABSTRACT

Objective:

This study was to investigate the role of serum Klotho, fetuin-A, and Matrix Gla Protein (MGP) in Coronary Artery Calcification (CAC) in patients with Maintenance Hemodialysis (MHD) and their predictive value for CAC.

Methods:

100 patients receiving MHD were selected. Serum Klotho, fetuin-A, and MGP levels were detected by ELISA. CAC scores were assessed by coronary CT scan. Multifactor analysis was used to evaluate the risk factors affecting CAC. The ability of serum Klotho, fetuin-A, and MGP levels to diagnose CAC was evaluated by receiver operating characteristic curves.

Results:

Serum Klotho, fetuin-A, and MGP were independent risk factors for CAC. Serum Klotho, fetuin-A, and MGP were valuable in the diagnosis of CAC in MHD patients.

Conclusion:

There is a close relationship between Klotho, fetuin-A, and MGP levels in MHD patients and CAC.

Keywords:
Maintenance hemodialysis patients; Klotho; Fetuin-A; MGP; Coronary artery calcification

HIGHLIGHTS

Serum Klotho, fetuin-A, and MGP were independent risk factors for CAC.

Serum Klotho, fetuin-A, and MGP were valuable in the diagnosis of CAC in MHD patients.

There is a close relationship between Klotho, fetuin-A, and MGP levels in MHD patients and CAC.