Wright et al. (2222. Wright CS, Laing EM, Pollock NK, Hausman DB, Weaver CM, Martin BR, et al. Serum 25-Hydroxyvitamin D and Intact Parathyroid Hormone Influence Muscle Outcomes in Children and Adolescents. J Bone Miner Res. 2018;33(11):1940-7. https://doi.org/10.1002/jbmr.3550 https://doi.org/10.1002/jbmr.3550...
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Blood samples after an overnight fast. Serum 25OHD was evaluated using a two-step radioimmunoassay. |
Digital dynamometer. |
Before intervention in 318 participants: 69.9±18.5 nmol/L. After intervention of vitamin D of 12 weeks: Δ 22.37±32.99 nmol/L. |
Oral dose of vitamin D3 of 0, 400, 1000 or 4000 IU/day. Time: 12 weeks. |
Handgrip strength before intervention in 288 participants: 176.52±93.16 N. After 12-week intervention: Δ 7.25±25.49 N. |
Bozsodi et al. (2828. Bozsodi A, Boja S, Szilagyi A, Somhegyi A, Varga PP, Lazary A. Muscle strength is associated with vitamin D receptor gene variants. J Orthop Res. 2016;34(11):2031-7. https://doi.org/10.1002/jor.23220 https://doi.org/10.1002/jor.23220...
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For genotyping, saliva samples were analyzed using the Orange OG-500 kit. |
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Six candidates for single nucleotide polymorphisms were identified: A1012G, Fokl, Ddel, Bsml, Taql, and rs10783215. |
Without intervention. |
Handgrip strength in 706 participants: dominant hand strength 147.5±42.1 N. |
Filteau et al. (2525. Filteau S, Rehman AM, Yousafzai A, Chugh R, Kaur M, Sachdev HP, et al. Associations of vitamin D status, bone health and anthropometry, with gross motor development and performance of school-aged Indian children who were born at term with low birth weight. BMJ Open. 2016;6(1):e009268. https://doi.org/10.1136/bmjopen-2015-009268 https://doi.org/10.1136/bmjopen-2015-009...
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Radioimmunoassay duplicate using a DiaSorin kit and an external standard (vitamin D external Quality Assessment Scheme, DEQAS). |
Custom dynamometer. |
902 participants: 32.7±23.0 nmol/L. |
Without intervention. |
Handgrip strength in 830 participants: 24.41±9.12 N. |
Mortensen et al. (2323. Mortensen C, Mølgaard C, Hauger H, Kristensen M, Damsgaard CT. Winter vitamin D3 supplementation does not increase muscle strength, but modulates the IGF-axis in young children. Eur J Nutr. 2019;58(3):1183-92. https://doi.org/10.1007/s00394-018-1637-x https://doi.org/10.1007/s00394-018-1637-...
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A 25 mL venous sample of blood was collected after 2 to 4h of fasting. The 25OHD serum was analyzed by tandem mass spectrometry liquid chromatography. |
Manual dynamometer. |
117 participants: 56.1±12.8 nmol/L. Placebo group before the intervention: 55.6±1.7 nmol/L. After intervention: 31.4±1.2 nmol/L The 10 μg/day group before the intervention: 56.9±2.1 nmol/L. After intervention: 61.8±1.7 nmol/L. The 20 μg/day group before the intervention: 58.6±2.1 nmol/L After intervention: 76.0±1.8 nmol/L. |
Vitamin D3 supplementation was performed for 20 weeks. Subjects were divided into three groups: Placebo: 40 subjects. 10 μg/day: 38 individuals. 20 μg/day: 39 individuals. |
Mean peak strength for the placebo group before the intervention: 92.18±4.9 N. After intervention: 98.06±5.88 N. 10 μg/day before the intervention: 107.87±5.88 N. After intervention: 112.78±5.88 N. 20 μg/day before the intervention: 106.89±4.90 N. After intervention: 109.83±4.90 N. |
Trilok-Kumar et al. (2626. Trilok-Kumar G, Kaur M, Rehman AM, Arora H, Rajput MM, Chugh R, et al. Effects of vitamin D supplementation in infancy on growth, bone parameters, body composition and gross motor development at age 3-6 years: follow-up of a randomized controlled trial. Int J Epidemiol. 2015;44(3):894-905. https://doi.org/10.1093/ije/dyv116 https://doi.org/10.1093/ije/dyv116...
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Serum OHD duplicate in radioimmunoassay using a Diasorin kit. An external standard (DEQAS). |
Custom design dynamometer. |
436 participants who supplemented vitamin D early in life: 32.0 nmol/L. 461 participants in the placebo group: 33.6 nmol/L. |
Without intervention. |
Early intervention group of vitamin D in 405 participants: 24.71±8.72 N. Placebo group 425 participants: 24.02±9.51 N. |
Al-Jwadi et al. (2424. Al-Jwadi RF, Jespersen E, Dalgård C, Bilenberg N, Christesen HT. S-25OHD Is Associated With Hand Grip Strength and Myopathy at 5 Years in Girls: An Odense Child Cohort Study. J Clin Endocrinol Metab. 2018;103(7):2630-9. https://doi.org/10.1210/jc.2018-00281 https://doi.org/10.1210/jc.2018-00281...
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25OHD serum levels were analyzed by liquid chromatography mass spectrometry. |
Digital hand Dynamometer. |
499 participants: 70.73±24.48 nmol/L. |
Without intervention. |
881 participants: 82.76±16.96 N. |