Bussalino et al. (22) (Case report) |
-32 years old -Male -3 years KT -Deceased donor -ESRD etiology was unknown -FK+MMF+Prednisone |
-Three days of fever (38°C) -SpO2 97% -Dyspnea -Non-productive cough |
-CRP 47.9 mg/L -PCT 0.33 μg/L -Creatinine 2.6 mg/dl -GFR 31 ml/min/1.73m2 -RT-PCR positive for SARS-CoV-2 |
-Prednisone dose was increased to 15 mg/day -FK+MMF maintained -hydroxychloroquine -Oseltamivir -Ceftaroline -Oxygen administration by nasal catheters |
-Patient had a satisfactory clinical evolution -Renal function remained similar to that at admission |
Marx et al. (28) (Correspondence) |
-58 years old -Male -3 years KT -Renal vein thrombosis -Balatacept+MMF+Prednisone |
-Fever (38°C) -Dyspnea -Cough -History of contact with a person who received a COVID-19 diagnosis |
-RT-PCR positive for SARS-CoV-2 -Pulmonary ground-glass opacities on CT |
-Belatacept and MMF suspended at hospital admission |
-Patient had a satisfactory evolution, without the necessity of mechanical ventilation or supplementary oxygen -Introduced cyclosporine on the 7th hospitalization day |
Bartiromo et al. (23) (Case report) |
-36 years old -Female -First KT in 1993 -Second KT in 1995 (Cadaveric donor) -Senior-Loken syndrome -FK+Corticoesteroids |
-Afebrile (36.3°C) -SpO2 97% -Fatigue -Dry cough -Coryza -History of contact with her mother who received a COVID-19 diagnosis |
-CRP 67 mg/L -Creatinine 2.29 mg/dl -GFR 27 ml/min -RT-PCR positive for SARS-CoV-2 |
-Lopinavir/ritonavir* -Hydroxychloroquine -Ceftriaxone *On the 2nd hospitalization day, patient presented with nausea and diarrhea, so the therapy with lopinavir/ritonavir was replaced with darunavir/cobicistat |
- On the 4th hospitalization day, the patient presented with abdominal pain, nausea, and diarrhea. -Had a good clinical evolution -Medical release on the 9th hospitalization day |
Ning et al. (24) (Case report) |
-29 years old -Male -2 years KT (Living donor) -Cyclosporine+MMF+methylprednisolone |
-Fever (37.7°C) -Without other symptoms in admission -During hospitalization (2nd day), patient presented with nasal stuffiness, hyporexia, nausea, and vomiting |
-First test RT-PCR negative for SARS-CoV-2 -Pulmonary ground-glass opacities on CT -Second test RT-PCR positive for SARS-CoV-2 (3rd hospitalization day) |
-TMP-SMX (admission) -Immunosuppressive treatment was maintained -Lopinavir/ritonavir (after RT-PCR test was positive) -Probiotics |
-On the 3rd hospitalization day, patient presented with dizziness, nausea, vomit, oliguria, and hematuria -Laboratory tests revealed elevated creatinine levels and hyponatremia -Patient received fluids and had better renal function -Medical release on the 12th hospitalization day |
Wang et al. (10) (Correspondence) |
-49 years old -Male -2 years KT -Cyclosporine+MMF+ Prednisone |
-Fever for six days -Without other symptoms in admission |
-WBC 7.18×109/L, -Lymphs 0.59×109/L -CRP 22.73 mg/L -PCT 0.36 μg/L -Creatinine 1.44 mg/dl -RT-PCR positive for SARS-CoV-2 -Pulmonary ground-glass opacities on CT |
-Nebulized α- interferon -Immunosuppressive treatment was maintained -Ribavirin -Lopinavir/ritonavir -Methylprednisolone -Oxygen administration by nasal catheters |
-Patient had a good clinical evolution, without an impact on renal function |
|
Case 1 -38 years old -Male -3 months KT (Deceased donor) |
-Fever (38.9°C) -SpO2 99% -Cough |
-WBC 4.73×109/L, -Lymphs 0.59×109/L -CRP 6.68 mg/L -Creatinine 1.10 mg/dl -RT-PCR positive for SARS-CoV-2 |
-Antiviral therapy (oseltamivir or arbidol) |
-Patient had a good clinical evolution, without the necessity of mechanical ventilation |
|
Case 2 -64 years old -Male -4 years KT (Deceased donor) |
-Fever (38.3°C) -SpO2 96% -Cough -Sputum -Fatigue |
-WBC 17.67×109/L, -Lymphs 0.55×109/L -CRP 337.11 mg/L -Creatinine 4.65 mg/dl -RT-PCR positive for SARS-CoV-2 |
-Antiviral therapy (oseltamivir or arbidol) -Cefixime |
-Patient had anuria, persistent fever, normal CT chest, and an elevation of creatinine levels - Realized methylprednisolone pulse therapy, due rejection suspect -Had a good clinical evolution |
Zhang et al. (25) (Case Series) |
Case 3 -37 years old -Female -5 months KT (Deceased donor) |
-Fever (39°C) -SpO2 99% -Cough |
-WBC 5.67×109/L, -Lymphs 0.31×109/L -CRP 9.77 mg/L -Creatinine 1.54 mg/dl -RT-PCR positive for SARS-CoV-2 |
-Antiviral therapy (oseltamivir or arbidol) -IV immunoglobulin |
-Patient had a good clinical evolution, without the necessity of mechanical ventilation |
Case 4 -47 years old -Male -11 months KT (Deceased donor) |
-Fever (39.8°C) -SpO2 98% -Cough -Sputum -Fatigue |
-WBC 3.99×109/L, -Lymphs 0.51×109/L -CRP 13.38 mg/L -Creatinine 1.66 mg/dl -RT-PCR positive for SARS-CoV-2 |
-Antiviral therapy (oseltamivir or arbidol) |
-Patient had a good clinical evolution, without the necessity of mechanical ventilation |
Case 5 -38 years old -Male -3 years KT (Deceased donor) |
-Fever (39.1°C) -SpO2 97% -Cough -Sputum -Fatigue |
-WBC 6.44×109/L, -Lymphs 0.91×109/L -CRP 33.72 mg/L -Creatinine 1.53 mg/dl -RT-PCR positive for SARS-CoV-2 |
-Antiviral therapy (oseltamivir or arbidol) |
-Patient had a good clinical evolution, without the necessity of mechanical ventilation |
Chen et al. (26) (Case report) |
-49 years old -Male -6 years KT (Deceased donor) -FK+MMF -Prednisolone |
-Fever (38.6°C) -Hyporexia -Dry cough |
-WBC 3.44×109/L, -Lymphs 0.43×109/L -CRP 74.34 mg/L -Creatinine 1.84 mg/dl -RT-PCR positive for SARS-CoV-2 -Pulmonary ground-glass opacities on CT |
-MMF and prednisolone were suspended -Methylprednisolone -Ribavirin -Immunoglobin -Moxifloxacin |
-Patient had worsening blood oxygen saturation, and oxygen inhalation was initiated. -Had a satisfactory clinical evaluation |
Seminari et al. (27) (Case report) |
-50 years old -Male -First KT 1993, failure 2008 -Second KT 2016 (4 years) -IgA nephropathy -FK+MMF |
-Fever (37.3°C) -Cough |
-WBC 3.2×109/μL -Lymphs 0.6×109/μL -RT-PCR positive SARS-CoV-2 -Chest x-ray showed interstitial lesions |
-Immunosuppressive treatment was maintained -Lopinavir/ritonavir -Ceftriaxone |
-Patient had a good clinical evolution, without the necessity of mechanical ventilation |
Gandolfini et al. (29) (Correspondence) |
Case 1 -75 years old -Male -10 years KT (Deceased donor) -FK+MMF -Prednisolone |
-Fever (38-39°C) -Cough -Myalgia -Dyspnea |
-WBC 6.56×109/L, -Lymphs 0.80×109/L -CRP 180 mg/L -PCT 1.29 ng/ml -Creatinine 2.2 mg/dl -RT-PCR positive for SARS-CoV-2 -Pulmonary ground-glass opacities on CT |
-FK+MMF was discontinued -Lopinavir/ritonavir -Hydroxychloroquine |
-Patients presented with significant worsening of respiratory function and evolved to death |
Case 2 -52 years old -Female -8 months KT (Deceased donor) -FK+MMF -Prednisolone |
-Fever (38-39°C) -Cough -Fatigue -Dyspnea -Diarrhea |
-WBC 2.54×109/L, -Lymphs 0.11×109/L -CRP 158 mg/L -PCT 0.98 ng/ml -Creatinine 2.4 mg/dL -RT-PCR positive for SARS-CoV-2 -Pulmonary ground-glass opacities on CT |
-FK+MMF was discontinued -Dorunavir/cobicistat -Hydroxychloroquine |
-Patient received non-invasive oxygen therapy -Had a good clinical evaluation |
Guillen et al. (30) (Case report) |
-50 years old -Male -3rd KT (4 years ago) -IgA nephropathy -FK+everolimus+ prednisone |
*1st day -Fever (38.2°C) -Vomiting -Signs of dehydration *5th day -Fever (37.4°C) -Crackles in the right lower lung -Conjunctivitis of the left eye |
*1st day -WBC 8.58×109/L -CRP<0.50 mg/dL -Creatinine 1.6 mg/dL, -GFR 50 mL/min *5th day -WBC 10.15×109/L -CRP 13.2 mg/dL -Creatinine 1.6 mg/dL, -GFR 50 mL/min -RT-PCR positive for SARS-CoV-2 |
-FK+Everolimus was discontinued -Lopinavir/ritonavir -Hydroxychloroquine -Ceftaroline+meropenem |
-Patient had worsening respiratory function, and mechanical ventilation was initiated. -Until the publication of this article, the patient remains in intensive respiratory support |
Fernández-Ruiz et al. (7) (Case series) |
Case 1 -78 years old -Male -8.3 years of KT -Polycystic kidney disease -Prednisone+FK |
-Fever -SpO2 89% -Dyspnea |
-Unilateral consolidation on chest X-ray -RT-PCR positive for SARS-CoV-2 |
-Lopiravir/ritonavir -Reduction of FK doses |
-Patient had respiratory failure and atrial fibrillation -Evolved to death after 5 days |
Case 2 -73 years old -Male -1.8 years of KT -Hypertensive nephropathy -Prednisone+FK+MPA |
-Fever -SpO2 94% -Dyspnea -Cough |
-Unilateral consolidation on chest X-ray -RT-PCR positive for SARS-CoV-2 |
-Lopinavir/ritonavir -Reduction of FK doses -Suspended prednisone+MPA |
-Patient had myopericarditis -Had a satisfactory clinical evolution |
Case 3 -80 years old -Male -3.8 years of KT -Hypertensive nephropathy -Prednisone+FK+MPA |
-SpO2 90% -Dyspnea -Cough -Hyporexia -Myalgia |
-RT-PCR positive for SARS-CoV-2 |
-Lopinavir/ritonavir -Hydroxychloroquine -Reduction of FK doses -Suspended MPA |
-Patient had worsening respiratory function -Evolved to death after 16 days |
Case 4 -71 years old -Female -6 years of KT -Unknown cause of renal failure -Prednisone+FK+MPA |
-Fever -SpO2 97% -Dyspnea -Cough -Sore throat |
-Bilateral interstitial pneumonia -RT-PCR positive for SARS-CoV-2 |
-Lopinavir/ritonavir -Hydroxychloroquine -Suspended MPA+prednisone |
-Patient evolved to death after 16 days |
Case 5 -71 years old -Male -30.1 years of KT -Polycystic kidney disease -FK |
-Fever -SpO2 100% -Epigastric pain |
-RT-PCR positive for SARS-CoV-2 |
-Hydroxychloroquine -Intravenous immunoglobulin -Reduction of FK doses |
-Patient showed an improvement in abdominal pain and was discharged home but returned to the hospital due to clinical worsening |
Case 6 -76 years old -Male -14.8 years of KT -IgA nephropathy -Prednisone+MMF+rapamycin |
-Fever -SpO2 96% -Rhinorrhea |
-Bilateral interstitial pneumonia -RT-PCR positive for SARS- CoV-2 |
-Hydroxychloroquine -Suspended MMF |
-Patient had a good clinical evolution, without the necessity of mechanical ventilation |
Case 7 -39 years old -Male -16.8 years of KT -Polycystic kidney disease -Prednisone+FK+ Everolimus |
-Fever -SpO2 100% -Myalgia |
-RT-PCR positive for SARS- CoV-2 |
-Hydroxychloroquine -Suspended FK+everolimus |
Patient had worsening respiratory function but showed mild radiological improvement |
Case 8 -65 years old -Male -6.5 years of KT -Chronic interstitial nephritis - Prednisone+FK+MPA |
-Fever -SpO2 93% -Myalgia -Dyspnea -Cough |
-Unilateral focal consolidation on chest X-ray -RT-PCR positive for SARS- CoV-2 |
-Lopinavir/ritonavir -Hydroxychloroquine -Reduced doses of MPA and FK |
-Patient had a positive clinical evolution |