PDZK1 is correlated with DCE-MRI perfusion parameters in high-grade glioma

Zhang, Yi; Wang, Feng; Huang, YongLi

doi:10.1016/j.clinsp.2024.100367

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Sumário

Original articles • Clinics 79 • 2024 • https://doi.org/10.1016/j.clinsp.2024.100367 copy

PDZK1 is correlated with DCE-MRI perfusion parameters in high-grade glioma

Authorship SCIMAGO INSTITUTIONS RANKINGS

Highlights

PDZK1 is up-regulated in cancer tissues of HGG patients.
PDZK1 expression was significantly positively correlated with k^trans ₉₀, v_{e_90}.
PDZK1 expression was negatively correlated with k_{ep_max}, k_{ep_90}.
Patients with high PDZK1 expression had poor OS and PFS.

Abstract

Objective

This study investigated the relationship between PDZK1 expression and Dynamic Contrast-Enhanced MRI (DCE-MRI) perfusion parameters in High-Grade Glioma (HGG).

Methods

Preoperative DCE-MRI scanning was performed on 80 patients with HGG to obtain DCE perfusion transfer coefficient (K^trans), vascular plasma volume fraction (v_p), extracellular volume fraction (v_e), and reverse transfer constant (k_ep). PDZK1 in HGG patients was detected, and its correlation with DCE-MRI perfusion parameters was assessed by the Pearson method. An analysis of Cox regression was performed to determine the risk factors affecting survival, while Kaplan-Meier and log-rank tests to evaluate PDZK1′s prognostic significance, and ROC curve analysis to assess its diagnostic value.

Results

PDZK1 was upregulated in HGG patients and predicted poor overall survival and progression-free survival. Moreover, PDZK1 expression distinguished grade III from grade IV HGG. PDZK1 expression was positively correlated with K^{trans 90}, and v_{e_90}, and negatively correlated with k_{ep_max}, and k_{ep_90}.

Conclusion

PDZK1 is upregulated in HGG, predicts poor survival, and differentiates tumor grading in HGG patients. PDZK1 expression is correlated with DCE-MRI perfusion parameters.

Keywords
Pdzk1; High-grade glioma; Prognosis; DCE-MRI; Perfusion parameter

		Glioma grade
Perfusion parameters	High-grade glioma (n = 80)	Grade III (n = 24)	Grade IV (n = 56)	p
Ktrans max	0.48 ± 0.22	0.43 ± 0.21	0.50 ± 0.24	0.197
Ktrans 90	0.12 ± 0.07	0.06 ± 0.03	0.15 ± 0.07	<0.001
Ktrans skew	3.85 ± 1.75	4.15 ± 2.04	3.72 ± 1.76	0.343
Ktrans kurt	46.47 ± 20.64	55.64 ± 32.50	42.52 ± 21.88	0.08
vp_max	0.35 ± 0.13	0.31 ± 0.12	0.37 ± 0.17	0.078
vp_90	0.12 ± 0.06	0.11 ± 0.05	0.13 ± 0.07	0.154
vp_skew	2.57 ± 1.28	2.21 ± 1.15	2.72 ± 1.46	0.1
vp_kurt	12.84 ± 7.22	11.07 ± 5.26	13.60 ± 6.71	0.076
ve_max	0.88 ± 0.32	0.78 ± 0.42	0.92 ± 0.55	0.22
ve_90	0.31 ± 0.16	0.18 ± 0.10	0.44 ± 0.21	<0.001
ve_skew	5.18 ± 2.32	6.19 ± 3.82	4.74 ± 2.20	0.092
ve_kurt	70.67 ± 48.16	85.37 ± 49.43	64.37 ± 34.92	0.068
kep_max	2.04 ± 0.84	2.54 ± 1.52	1.83 ± 0.91	0.012
kep_90	0.65 ± 0.24	0.80 ± 0.45	0.59 ± 0.30	0.016
kep_skew	4.05 ± 2.16	4.28 ± 2.37	3.95 ± 2.12	0.56
kep_kurt	68.18 ± 32.96	58.86 ± 28.09	72.17 ± 37.80	0.087

	PDZK1
Perfusion parameters	r	p
K^trans ₉₀	0.432	0.006
v_{e_90}	0.414	0.007
k_{ep_max}	−0.338	0.034
k_{ep_90}	−0.365	0.021

Parameters	Overall survival			Progression-free survival
	HR	95 % CI	p	HR	95 % CI	p
Age	1.08	1.04‒1.12	0.001	1.04	1.02‒1.07	<0.001
Glioma grade	7.01	1.57‒29.83	0.006	3.44	1.58‒7.45	0.003
v_{p_skew}	1.16	1.01‒1.33	0.021	0.82	0.46‒1.44	0.472
v_{p_kurt}	1.04	1.02‒1.06	0.007	0.87	0.50‒1.51	0.527
v_{e_90}	3.15	1.28‒7.99	0.026	2.7	1.23‒5.95	0.015
v_{e_skew}	0.92	0.85‒1.00	0.08	0.93	0.87‒0.99	0.036
k_{ep_90}	0.45	0.20‒0.97	0.045	0.78	0.50‒1.20	0.249
PDZK1	2.12	1.16‒5.32	0.001	1.78	1.07‒4.81	<0.001

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E-mail: clinics@hc.fm.usp.br

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[1] ⁎ Corresponding author. E-mail address:buchor2023@outlook.com (Y. Zhang)