McElroy et al. (88. McElroy CL, Gissen SA, Fishbein MC. Exercise-induced reduction in myocardial infarction size after coronary artery occlusion in rat. Circulation. 1978;57(5):958-62. https://doi.org/10.1161/01.CIR.57.5.958. https://doi.org/10.1161/01.CIR.57.5.958...
) |
8 |
2 |
4 |
Swimming 1h/day, 5 days/week, for 5 weeks |
- |
- |
48 hours of T- 2 days of DET |
IF, biometrics analysis, determination of capillary/fiber ratio. |
Dayan et al. (99. Dayan A, Feinberg MS, Holbova R, Deshet N, Scheinowitz M. Swimming exercise training prior to acute myocardial infarction attenuates left ventricular remodeling and improves left ventricular function in rats. Ann Clin Lab Sci. 2005;35(1):73-8.) |
35 |
3 |
14 (Ex), 14 (Sed), 7 (Control) |
Swimming 90 min/day, 5 days/week for 3 weeks |
- |
60-65% of VO2 máx |
3 weeks of T - 4 weeks of DET. |
Heart characteristics, Echo. |
Freimann et al. (1010. Freimann S, Scheinowitz M, Yekutieli D, Feinberg MS, Eldar M, Kessler-Icekson G. Prior exercise training improves the outcome of acute myocardial infarction in rat. Heart structure, function, and gene expression. J Am Coll Cardiol. 2005;45(6):931-8. https://doi.org/10.1016/j.jacc.2004.11.052. https://doi.org/10.1016/j.jacc.2004.11.0...
) |
- |
- |
- |
Swimming 90 min/day, 5 days/week for 7 weeks |
- |
60-65% of VO2 máx |
11 weeks of T - 3 weeks of DET. |
IF, blood vessels count, echo, analysis of gene expression. |
de Waard et al. (1212. de Waard MC, Duncker DJ. Prior exercise improves survival, infarct healing, and left ventricular function after myocardial infarction. J Apply Physiol. 2009;107(3):928-36. https://doi.org/10.1152/japplphysiol.91281.2008. https://doi.org/10.1152/japplphysiol.912...
) |
186 |
6 |
- |
2 weeks of voluntary wheel running |
30% increase of skeletal muscle citrate synthase activity |
60-65% of VO2 máx |
16 weeks of T - 8 weeks of DET. |
Survival, IF, determination of capillary/fiber ratio, capillary density, collagen content, apoptosis. |
Freimann et al. (1111. Freimann S, Kessler-Icekson G, Shahar I, Radom-Aizik S, Yitzhaky A, Eldar M, et al. Exercise training alters the molecular response to myocardial infarction. Med Sci Sports Exerc. 2009;41(4):757-65. https://doi.org/10.1249/MSS.0b013e31819125b6. https://doi.org/10.1249/MSS.0b013e318191...
) |
- |
- |
- |
Swimming 90 min/day, 6 days/week for 7 weeks |
- |
60-65% of VO2 máx |
4 hours, 2 days and 4 weeks of T - |
DNA microarray analysis, RT-q PCR, heart and body weight, gene expression profiles. |
Tang et al. (1313. Tang XY, Hong HS, Chen LL, Lin XH, Lin JH, Lin Z. Effects of exercise of different intensities on the angiogenesis, infarct healing, and function of the left ventricle in postmyocardial infarction rats. Coron Artery Dis. 2011;22(7):497-506. https://doi.org/10.1097/MCA.0b013e32834993d9. https://doi.org/10.1097/MCA.0b013e328349...
) |
30 |
6 |
5 |
Treadmill running exercise 60 min/day, 5 days/week for 6 weeks |
Levels of plasma lactic acid examined |
High-intensity; moderate intensity; low intensity |
7 weeks of T- one week of DET. |
IF, determination of capillary/fiber ratio, micro vessel density, western blot analysis of VEGF. |
Veiga et al. (1414. Veiga EC, Antonio EL, Bocalini DS, Murad N, Abreu LC, Tucci PJ, et al. Prior exercise training does not prevent acute cardiac alterations after myocardial infarction in female rats. Clinics. 2011;66(5):889-93. https://doi.org/10.1590/S1807-59322011000500028. https://doi.org/10.1590/S1807-5932201100...
) |
44 |
4 |
11 |
Swimming 60 min/day, 5 days/week for 8 weeks |
Physical capacity swin test (ref) |
60-65% of VO2 máx |
9 weeks of T- one week of DET. |
Evaluation of area of risk of infarcted myocardial, Echo. |
Bozi et al. (1616. Bozi LH, Maldonado IR, Baldo MP, Silva MF, Moreira JB, Novaes RD, et al. Exercise training prior to myocardial infarction attenuates cardiac deterioration and cardiomyocyte dysfunction in rats. Clinics. 2013;68(4):549-56. https://doi.org/10.6061/clinics/2013(04)18. https://doi.org/10.6061/clinics/2013(04)...
) |
55 |
3 |
15 (Sham), 20 (SedMI), 20 (EXMI) |
Aerobic exercise training running 60 min/day, 5 days/week for 8 weeks |
Underwent a graded treadmill exercise training until exhaustion for 3 days with 2 different observers |
55-70% of exercise intensity |
10 weeks of T- 2 weeks of DET. |
Determination of capillary/fiber ratio, in situ LV pressure-volume relationship, histologic evaluation, cardiomyocyte contractile function and morphology. |
Veiga et al. (1515. Veiga EC, Portes LA, Bocalini DS, Antonio EL, Santos AA, Santos MH, et al. Cardiac implications after myocardial infarction in rats previously undergoing physical exercise. Arq Bras Cardiol. 2013;100(1):37-43. https://doi.org/10.1590/S0066-782X2012005000117. https://doi.org/10.1590/S0066-782X201200...
) |
40 |
4 |
10 |
Swimming 60 min/day, 5 days/week for 8 weeks |
Physical capacity swin test (ref) |
60-65% of VO2 máx |
12 weeks of T- 4 weeks of DET. |
IF, determination of capillary/fiber ratio, papillary measurement. |
Rodrigues et al. (1717. Rodrigues F, Feriani DJ, Barboza CA, Abssamra ME, Rocha LY, Carrozi NM, et al. Cardioprotection afforded by exercise training prior to myocardial infarction is associated with autonomic function improvement. BMC Cardiovasc Disord. 2014;14:84. https://doi.org/10.1186/1471-2261-14-84. https://doi.org/10.1186/1471-2261-14-84...
) |
40 |
4 |
10 |
Treadmill running exercise 60 min/day, 5 days/week for 8 weeks |
Maximal running speed achieved in the test present a good correlation with the maximum oxygen consumption |
72 to 75% of VO2 max |
8.5 weeks of T- few days of DET. |
IF, determination of capillary/fiber ratio, LV morphometry and function, cardiac autonomic modulation. |
Santos et al. (1818. Santos MH, Higuchi Mde L, Tucci PJ, Garavelo SM, Reis MM, Antonio EL, et al. Previous exercise training increases levels of PPAR-α in long-term post-myocardial infarction in rats, which is correlated with better inflammatory response. Clinics. 2016;71(3):163-8. https://doi.org/10.6061/clinics/2016(03)08. https://doi.org/10.6061/clinics/2016(03)...
) |
54 |
6 |
9 |
Swimming 60 min/day, 5 days/week for 8 weeks |
- |
60-65% of VO2 máx |
12 or 9 weeks of T- 1 or 4 weeks of DET. |
IF, echo, immunohistochemistry, antigen quantification, apoptosis. |
Barbosa et al. (1919. Barboza CA, Souza GI, Oliveira JC, Silva LM, Mostarda CT, Dourado PM, et al. Cardioprotective Properties of Aerobic and Resistance Training Against Myocardial Infarction. Int J Sports Med. 2016;37(6):421-30. https://doi.org/10.1055/s-0035-1565136. https://doi.org/10.1055/s-0035-1565136...
) |
42 |
4 |
11 |
Treadmill running exercise 60 min/day, 5 days/week for 8 weeks |
- |
Low to moderate intensity |
8.5 weeks of T - few days of DET. |
Determination of capillary/fiber ratio, cardiovascular autonomic modulation, cytokines concentration by ELISA. |
Vieira et al. (2020. de Souza Vieira S, Antonio EL, de Melo BL, Portes LA, Montemor J, Oliveira HA, et al. Exercise Training Potentiates The Cardioprotective Effects of Stem Cells Post-infarction. Heart Lung Circ. 2019;28(2):263-71. https://doi.org/10.1016/j.hlc.2017.11.005. https://doi.org/10.1016/j.hlc.2017.11.00...
) |
130 |
4 |
35 |
Swimming 90 min/day, 5 days/week for 9 weeks |
VO2 peak (ml.kg-1.min-1) was used as marked of cardiorespiratory fitness |
3x greater exercise intensity |
13 weeks of T -4 weeks of DET |
IF, echo, papillary measurements, apoptosis assay, histomorphometry, immunoblotting |