Correlation analysis between serum total IgE and FeNO and idiosyncratic reaction in bronchiolitis

Xu, XiaoYing; Han, WeiNing; Han, WeiPing

doi:10.1016/j.clinsp.2024.100384

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Sumário

Original articles • Clinics 79 • 2024 • https://doi.org/10.1016/j.clinsp.2024.100384 copy

Correlation analysis between serum total IgE and FeNO and idiosyncratic reaction in bronchiolitis

Authorship SCIMAGO INSTITUTIONS RANKINGS

Highlights

FeNO in bronchiolitis children was lower than that in healthy children.
Serum total IgE increased while FeNO decreased with the aggravation of bronchiolitis in bronchiolitis children.
Serum total IgE was higher in children with idiosyncratic bronchiolitis, but serum total IgEand FeNO were not the risk factors for idiosyncratic bronchiolitis.
Area Under the Curve (AUC) of serum total IgE and FeNO for the diagnosis of idiosyncratic bronchiolitis was less than 0.7.

Abstract

Objective

This article focused on the correlation between the changes of serum total Immunoglobulin E (IgE) and Fractional exhaled Nitric Oxide (FeNO) and idiosyncratic reactions in children with bronchiolitis.

Methods

One hundred children with bronchiolitis and fifty healthy children were enrolled. Serum total IgE and FeNO were assessed, and the diagnostic value for bronchiolitis and the correlation with the severity of bronchiolitis were analyzed. Bronchiolitis children were divided into idiosyncratic + bronchiolitis and non-idiosyncratic + bronchiolitis groups, the relationship between serum total IgE and FeNO and idiosyncratic reaction was determined, and the diagnostic value of serum total IgE and FeNO for idiosyncratic bronchiolitis was examined.

Results

FeNO in bronchiolitis children was lower than that in healthy children but there was no significant difference in serum total IgE levels between the two populations. Serum total IgE increased while FeNO decreased with the aggravation of bronchiolitis in bronchiolitis children. The serum total IgE was positively correlated while FeNO was negatively correlated with the severity of bronchiolitis. Serum total IgE was higher in children with idiosyncratic bronchiolitis, but serum total IgE and FeNO were not the risk factors for idiosyncratic bronchiolitis; Area Under the Curve (AUC) of serum total IgE and FeNO for the diagnosis of idiosyncratic bronchiolitis was less than 0.7.

Conclusion

Serum total IgE and FeNO in children with bronchiolitis are related to disease severity and idiosyncratic reaction. FeNO has a diagnostic value for bronchiolitis, but not for idiosyncratic bronchiolitis.

Keywords
Bronchiolitis; Total immunoglobulin e; Fractional exhaled nitric oxide; Idiosyncratic Reaction

Groups		Bronchiolitis group (n = 100)	Healthy group (n = 50)	χ2/t	p
Gender	Male	67	30	0.715	0.398
Gender	Female	33	20
Age		1.05 ± 0.21	1.01 ± 0.23	1.065	0.289
Gestational age		40.03 ± 0.15	39.97 ± 0.16	1.506	0.134
Height (cm)		73.24 ± 3.37	72.95 ± 3.58	0.487	0.627
Body weight (kg)		10.07 ± 2.14	10.13 ± 2.06	0.164	0.87
Allergy history in first degree relative		18	4	2.663	0.102
Immediate family smoking history		31	14	0.143	0.705
Immediate family history of lung disease		17	10	0.203	0.652

Item	Mild	Moderate	Severe
Feeding amount	normal	To half normal	To half normal or food refusal
Respiratory rate	Normal or slightly faster	> 60 breaths/min	> 70 breaths/min
Chest wall inspiratory tri-concave sign	Mild or no	Moderate (obvious rib gap depression)	Severe (very obvious rib gap depression)
Nose flaring or moaning	No	No	Ye s
Oxygen saturation	> 92 %	88 %∼92 %	< 88 %
Mental state	Normal	slight or intermittent irritability, irritability	Extreme irritability, sleepiness, coma

	Cut-off value	AUC	SE	95 %CI	Specificity	Sensitivity
Serum total IgE	2.83	0.5	0.049	0.992∼0.596	98.04	12
FeNO	≤8	0.759^a a p < 0.05.	0.04	0.680∼0.838	76.47	71

Indicators	β	SE	Wald χ2	OR	95 %CI	p
Serum total IgE	0.171	0.235	0.529	1.186	0.749∼1.881	0.467
FeNO	−0.026	0.036	0.522	0.974	0.908∼1.046	0.471
Constant	−0.32	0.377	0.72	0.726	0.347∼1.520	0.396

Indicators	Cut-off value	AUC	SE	95 %CI	Specificity (%)	Sensitivity (%)
Serum total IgE	2.29 IU/mL	0.543	0.058	0.440∼0.643	88	26
FeNO	8 ppb	0.506	0.059	0.405∼0.608	78	36

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E-mail: clinics@hc.fm.usp.br

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[1] ⁎ Corresponding author. E-mail address:hanweiping86@hotmail.com (W. Han)