BACTERIAL PROFILE IN SPONDYLODISCITIS: COMPARING BIOPSY, BLOOD CULTURE AND UROCULTURE

VIEIRA, MORGANA MARQUES MELLO; NAVARRO, FERNANDA ANDREA MINUTTI; NAKAO, RODRIGO YUITI; RODRIGUES, LUIZ CLAUDIO LACERDA

doi:10.1590/S1808-185120242302284761

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Original Article: Tumor/Infection • Coluna/Columna. 23 (2) • 2024 • https://doi.org/10.1590/S1808-185120242302284761 copy

BACTERIAL PROFILE IN SPONDYLODISCITIS: COMPARING BIOPSY, BLOOD CULTURE AND UROCULTURE

PERFIL BACTERIANO NAS ESPONDILODISCITES: COMPARANDO BIÓPSIA, HEMOCULTURA E UROCULTURA

PERFIL BACTERIANO EN ESPONDILODISCITIS: COMPARANDO BIOPSIA, HEMOCULTIVO Y UROCULTIVO

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

Objective:

To evaluate and correlate the bacterial profile identified in blood cultures, urine cultures and vertebral biopsies in patients at Hospital Santa Marcelina in São Paulo - SP.

Methods:

Cross-sectional study of 20 patients affected by spondylodiscitis. Blood culture, urine culture, and spinal biopsy results were evaluated, in addition to sex and age.

Results:

The sample consisted of 20 patients, between 32 and 79 years old, predominantly male, diagnosed with spondylodiscitis. Most blood culture and urine culture results were negative, 80% and 65%, respectively. Among the spinal biopsy samples, 60% identified pathogens. When correlating the samples, 50% of the blood culture and biopsy cases presented the same result; however, between urine culture and biopsy, none identified the same germ between the samples.

Conclusion:

It is concluded that results from blood cultures, urine cultures, and spinal biopsies may frequently differ, making biopsy essential in diagnosing and treating spondylodiscitis.

Level of Evidence IV; Cross-Sectional Study.

Keywords:
Spine; Bone Diseases, Infectious; Diagnosis; Biopsy

Patient	Sex	Age	Hemoculture	Uroculture	Biopsia
patient 1	male	54	Negative	Negative	s. Epidermidis
Patient 2	male	58	Negative	Negative	Negative
Patient 3	male	45	E. Coli	K. Pneumoniae ssp pneumoniae	E. Coli
patient 4	female	70	Negative	Negative	s. Epidermidis
Patient 5	male	66	Negative	Negative	Negative
Patient 6	male	63	Negative	K. Pneumoniae/p. Mirabilis	S. Haemolyticus
patient 7	female	54	Negative	Negative	Negative
Patient 8	male	63	Negative	Negative	Negative
Patient 9	male	55	Negative	Negative	enterobacter clocae complex
Patient 10	female	79	Negative	Negative	staphylococcus capitis
Patient 11	male	65	S.Aureus	Negative	S. Aureus
Patient 12	female	43	Negative	Negative	s. Aureus
Patient 13	male	63	S.Aureus	Negative	E. Coli
Patient 14	male	32	Bacillus spp	Serratia maroescens	Pseudomonas aeruginosa
patient 15	female	73	Negative	Enterococcus faecalis	Negative
Patient 16	male	73	Negative	K. Pneumoniae ssp pneumoniae	Negative
Patient 17	male	67	Negative	E. Coli	Staphylococcus warneri
patient 18	male	56	Negative	E. Coli	Mycobacterium tuberculosis complex
Patient 19	female	39	Negative	Negative	Negative
Patient 20	female	61	Negative	Negative	Negative

		Frequency	%
Blood culture	Bacillus spp	1	5%
	E. coli	1	5%
	Negative	16	80%
	S.aureus	2	10%
Uroculture	E. coli	2	10%
	Enterococcus faecalis	1	5%
	K. pneumoniae ssp pneumoniae	2	10%
	K. pneumoniae/P. mirabilis	1	5%
	Negative	13	65%
	Serratia maroescens	1	5%
Biopsy	Mycobacterium tuberculosis complex	1	5%
	E. coli	2	10%
	Enterobacter clocae complex	1	5%
	Negative	8	40%
	Pseudomonas aeruginosa	1	5%
	S. aureus	2	10%
	S. epidermidis	2	10%
	S. haemolyticus	1	5%
	Staphylococcus capitis	1	5%
	Staphylococcus warneri	1	5%

		Frequency	%	p-value
Blood culture	Negative	16	80%	0.012*
Blood culture	Positive	4	20%
Uroculture	Negative	13	65%	0.346
Uroculture	Positive	7	35%
Biopsy	Negative	8	40.0%	0.371
Biopsy	Positive	12	60.0%

Blood culture
	Bacillus spp		E. coli		Negative		S.aureus
Biopsy	Frequency	%	Frequency	%	Frequency	%	Frequency	%
Mycobacterium tuberculosis complex	0	0	0	0	1	6.25	0	0
E. coli	0	0	1	100	0	0	1	50
Enterobacter clocae complex	0	0	0	0	1	6.25	0	0
Negative	0	0	0	0	8	50	0	0
Pseudomonas aeruginosa	1	100	0	0	0	0	0	0
S. aureus	0	0	0	0	1	6.25	1	50
S. epidermidis	0	0	0	0	2	12.5	0	0
S. haemolyticus	0	0	0	0	1	6.25	0	0
Staphylococcus capitis	0	0	0	0	1	6.25	0	0
Staphylococcus warneri	0	0	0	0	1	6.25	0	0

	Uroculture
	E. coli		Enterococcus faecalis		K. pneumoniae ssp pneumoniae		K. pneumoniae/P. mirabilis		Negative		Serratia maroescens
Biopsy	Frequency	%	Frequency	%	Frequency	%	Frequency	%	Frequency	%	Frequency	%
Mycobacterium tuberculosis complex	1	50	0	0	0	0	0	0	0	0	0	0
E. coli	0	0	0	0	1	50	0	0	1	7.7	0	0
Enterobacter clocae complex	0	0	0	0	0	0	0	0	1	7.7	0	0
Negative	0	0	1	100	1	50	0	0	7	53.8	0	0
Pseudomonas aeruginosa	0	0	0	0	0	0	0	0	0	0	1	100
S. aureus	0	0	0	0	0	0	0	0	2	15.4	0	0
S. epidermidis	0	0	0	0	0	0	0	0	1	7.7	0	0
S. haemolyticus	0	0	0	0	0	0	1	100	0	0	0	0
Staphylococcus capitis	0	0	0	0	0	0	0	0	1	7.7	0	0
Staphylococcus warneri	1	50	0	0	0	0	0	0	0	0	0	0

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[1] Correspondence: Luiz Claudio Lacerda Rodrigues. 43/cj 1102, Coronel Irineu de Castro Street, Jd Analia Franco, São Paulo, SP, Brazil. 03333-050. luizclrodrigues@yahoo.com.br