The use of levomepromazine to blockade the arrhythmia produced by the use of epinephrine in dogs given ketamine was evaluated. Thirthy adults crossbreed dogs, males and females with average weight from 7 to 15kg were used. The animals were alocated in three groups of 10 dogs each (G1, G2 and G3). To the G1 was administered epinephrine at 3, 6, 9, 12 and 15 mg/kg, intravenously, at 10 minutes intervals. From this dogs was measured the time of action of epinephrine (TA) and the number of premature ventriculary complexes (ESV), obtainded. To the G2 was intravenously administered 0.2ml/kg of saline solution. Ten minutes after each dog received 2mg/kg of ketamine and five minutes after it was started the intravenous continuously administered ketamine at 0.2mg/kg/min. After five minutes the epinephrine was given as the same way, doses and intervals as described for G1, followed by the measurements of TA and ESV. To the dogs from G3 was used the same method but replacing the saline solution by levomepromazine intravenously administered at 1mg/kg. The results showed that the levomepromazine decrease the TA and reduce the ESV, in ketamine anesthetized dogs.
levomepromazine; ketamine; arrhythmia; dogs
