Ioversol contrast agent, at a concentration of 240mg of iodine/ml, was administered via intrathecal routes to 30 normal dogs at a dose of 0.5ml/kg weight to determine possible cerebrospinal fluid and histopathological changes. Physical analysis, total and differential white cell counts and quantitative protein determination of the cerebrospinal fluid were done. Cerebrospinal fluid analysis revealed increase in the total white cell count in three animals, and protein in four animals of different groups post-myelography. Histopathological changes were seen in spinal cords of two dogs: mononuclear infiltrate in the ventral fissure and in the central canal, and mononuclear infiltrate in the central canal, respectively. Myelography with ioversol 240mg I/m<img src="http:/img/fbpe/cr/v32n3/a10img01.gif" align="absmiddle"> can cause mild cytological and protein alterations, and histopathological changes under the experimental conditions.
myelography; ioversol; dogs
