The antimicrobial activity of Apis mellifera propolis is widely reported, and the variations in this property according to the region where it was produced have been mentioned. Thus, the antimicrobial activity of propolis from three Brazilian regions (Botucatu, SP; Mossoró, RN and Urubici, SC) was investigated on isolated strains from human clinical material (Staphylococcus aureus, Escherichia coli, Enterococcus sp, Pseudomonas aeruginosa, and Candida albicans). Ethanolic Extracts of Propolis (EEP) were prepared and the Minimal Inhibitory Concentration (MIC) was determined based on the method of EEP dilution in agar and the MIC90% calculated. Propolis from Botucatu was the most effective against S. aureus (0.3%v/v), Enterococcus sp (1.1%v/v), and C. albicans (2.1% v/v). The effective propolis against E. coli was from Urubici (7.0%v/v), and against P. aeruginosa, from Mossoró (5.3%v/v). The results shows that there are differences in the activity according to the region where the propolis were produced and Gram positive bacteria were more susceptible that Gram negative bacteria.
Honeybee; ethanolic extracts; bacteria; Candida albicans
