<i>In vitro</i> lytic efficiency of <i>Staphylococcus aureus</i> bacteriophages in bacteria from bovine mastitis: a meta-analysis

Barasuol, Bibiana Martins; Ely, Valessa Lunkes; Matos, Antônio Francisco Igor Magalhães de; Sangioni, Luis Antônio; Vargas, Agueda Castagna de; Pereira, Daniela Isabel Brayer; Martini, Amanda Carneiro; Pötter, Luciana; Botton, Sônia de Avila

doi:10.1590/0103-8478cr20200839

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MICROBIOLOGY • Cienc. Rural 51 (10) • 2021 • https://doi.org/10.1590/0103-8478cr20200839 copy

In vitro lytic efficiency of Staphylococcus aureus bacteriophages in bacteria from bovine mastitis: a meta-analysis

Eficiência lítica in vitro de bacteriófagos de Staphylococcus aureus em bactérias de mastites bovina: uma meta-análise

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT:

Bacteriophages have been investigated as alternative to the treatment of bacterial infections, including bovine mastitis, in production animals. In this meta-analysis, we evaluated in vitro efficiency of phages of Staphylococcus aureus against S. aureus, which is involved in the etiology of bovine mastitis. Seventeen studies were included and the bacterial lytic activity was extracted using proportion analysis. The lytic efficiency of phages was obtained in this meta-analysis using a random-effects model [significant difference (P<0.05)]. Forest plots were used to graphically represent the efficiency of phages on bacterial isolates. Most phages (e.g., CS1, DW2, ΦSA011, ΦSA012, ΦSA022, ΦSA023, ΦSA024, ΦSA025, ΦSA037, ΦSA038, ΦSA039, ΦSA041, ΦSA042, ΦSA043, ΦSA044, MSA6, Ufv-aur2 to Ufv-aur11, SAH-1, SPW, vB_SauM_JS25, SaPh1 to SaPh6, SA, SANF, SA2, ΦSA012, ΦSA039, phi11, phiIPLA88, phiIPLA35, phiIPLA-RODI, phiIPLA-C1C, SAJK-IND, vBSP-A1, vBSP-A2, STA1.ST29, EB1.ST11, EB1.ST27, Remus, and ISP) were efficiently lytics or infected most S. aureus isolates, demonstrating 80% (P<0.05) lytic efficiency. The phages SA, SANF and SA2, also demonstrated lytic activity or infected the non-Staphylococcus aureus and Macrococcus caseolyticus isolates. In this meta-analysis, we compared and demonstrated the in vitro efficiency and host range of S. aureus phages. Additionally, the phages represent an alternative to be researched to treat bovine mastitis in dairy cattle caused by the prevalent microorganism, S. aureus.

Key words:
bacteriophages; bovine mastitis; phages; Staphylococcus aureus

Universidade Federal de Santa Maria Universidade Federal de Santa Maria, Centro de Ciências Rurais , 97105-900 Santa Maria RS Brazil , Tel.: +55 55 3220-8698 , Fax: +55 55 3220-8695 - Santa Maria - RS - Brazil
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[1] E-mail: sabott20@gmail.com. ^*Corresponding author

Author	Country	Phages family	Phages isolates	Analysis method	Bacterial isolated	Nº^**	Antimicrobial resistance
O’FLAHERTY et al., (2005O’FLAHERTY, S. et al. Isolation and characterization of two anti-staphylococcal bacteriophages specific for pathogenic Staphylococcus aureus associated with bovine infections. Letters in Applied Microbiology , v.41, n.6, p.482-486, 2005. Available from: <Available from: https://doi.org/10.1111/j.1472-765X.2005.01781.x >. Accessed: Jun. 06, 2018 . doi: 10.1111/j.1472-765X.2005.01781.x. https://doi.org/10.1111/j.1472-765X.2005... )	Ireland	Siphoviridae	CS1 DW2	Spot test	S. aureus	3	N/A
SYNNOTT et al., (2009)	Japan	Myoviridae	ΦSA003 ΦSA004 ΦSA011 ΦSA012 ΦSA022 to ΦSA026 ΦSA037 to ΦSA039 ΦSA041 to ΦSA044	Double-layered agar	S. aureus	16	N/A
GARCÍA et al., (2009)	Spain	N/A	ΦA72 ΦH5 ΦL7 ΦL13 ΦA8 ΦG7	Double-layered agar	S. aureus	14	N/A
SON et al., (2010)	Korea	Myoviridae	SAP-1 SAP-3	Double-layered agar	S. aureus; S. epidermidis; S. agalactie; S. uberis; E. faecalis; E. coli; L. plantarum; C. koseri; S. haemolyticus	20	Nal, Str, Gen, Ami, Ct, Cfl, Nor, Eri, Oxa
KWIATEK et al., (2012)	Poland	Myoviridae	MSA6	Double-layered agar	S. aureus; S epidermidis; S. saprophyticus	35	MRSA, VRSA
DIAS et al., (2013)	Brazil	Myoviridae	Ufv-aur2 to Ufv-aur11	Double-layered agar	S. aureus	20	Amp, Gen, Pen, Tet, Eri, Rif, Ami, Clo, Cro, Oxa, Cfl, Cli, Cip, Van, Sut
HAN et al. (2013)	Korea	Myoviridae	SAH-1	Double-layered agar	S. aureus; E. faecalis	47	MRSA
LI & ZHANG (2014)	China	Myoviridae	SPW	Spot test	S. aureus; E. coli	05	MRSA

Author	Country	Phages family	Phages isolates	Analysis method	Bacterial isolated	Nº^**	Antimicrobial resistance
ZHANG et al. (2014)	China	Myoviridae	vB_SauM_JS25	Spot test	S. aureus	52	N/A
BASDEW & LAING (2015)	South Africa	Myovoridae	SaPh1 to SaPh6	Spot test	S. aureus	4	Amp, Pen G, Met, A/F, Eri, Str, Tet, Ob, Van, Tr
TAHIR et al. (2017)	Pakistan	N/A	SA SANF SA2	Spot test	S. aureus; S. xylosus; M. caseolyticus; S. saprophyticus; S. succinus; S. sciuri	11	N/A
IWANO et al. (2018IWANO, H. et al. Bacteriophage ΦSA012 has a broad host range against Staphylococcus aureus and effective lytic vapacity in a mouse mastitis model. Biology, v.7, n.1, p.8, 2018. Available from: <Available from: https://doi.org/10.3390/biology7010008 >. Accessed: Apr. 18, 2018 . doi: 10.3390/biology7010008. https://doi.org/10.3390/biology7010008... )	Japan	Myoviridae	ΦSA012 ΦSA039	Spot test	S. aureus	93	N/A
VARELA-ORTIZ et al. (2018)	México	Siphoviridae Myoviridae	phi11 phiIPLA88 phiIPLA35 phiIPLA-RODI phiIPLA-C1C	Spot test	S. aureus	27	Pen, Dc, Amp, Tet, Ctx, Cfl, Pef, Gen, Eri, Stx, Caz, Cxm
GANAIE et al. (2018)	India	Myoviridae Podoviridae	SAJK-IND MSP	Spot test	S. aureus; E. coli; S. agalactie; K. pneumonie; P. aureuginosa	125	MRSA
GENG et al. (2019GENG, H. et al. Evaluation of phage therapy in the treatment of Staphylococcus aureus-induced mastitis in mice. Folia Microbiologica, 2019. Available from: <Available from: https://doi.org/10.1007/s12223-019-00729-9 >. Accessed: May, 02, 2018. doi: 0.1007/s12223-019-00729-9. https://doi.org/10.1007/s12223-019-00729... )	China	Myoviridae Podoviridae	vBSM-A1 vBSP-A2	Double-layered agar	S. aureus; S. chromogens; K. pneumoniae; S. parasanguinis A. pyogenes; S. agalactie; E. coli	29	N/A
TITZE et al. (2020TITZE, I. et al. Efficacy of bacteriophages against Staphylococcus aureus isolates from bovine mastitis. Pharmaceuticals, v.13, n.35, 2020. Available from: <Available from: https://doi.org/ 10.3390/ph13030035 >. Accessed: Nov. 12, 2020. doi: 10.3390/ph13030035. https://doi.org/ 10.3390/ph13030035... )	Germany	Myoviridae Podoviridae	STA1.ST29 EB1.ST11 EB1.ST27	Spot test	S. aureus	92	N/A
NGASSAM-TCHAMBA et al. (2020NGASSAM-TCHAMBA, C. et al. In vitro and in vivo assessment of phage therapy against Staphylococcus aureus causing bovine mastitis. Journal of Global Antimicrobial Resistance, v.22, p.762-770, 2020. Available from: <Available from: https:// doi.org/10.1016/j.jgar.2020.06.020 >. Accessed: Nov. 06, 2020. doi: 10.1016/j.jgar.2020.06.020. https:// doi.org/10.1016/j.jgar.2020.06.... )	Belgium	N/A	Romulus Remus ISP DSM105264	Spot test	S. aureus	10	Cfo, Amp, Tet, Amo, Cip, Cli, Ct, Eri, Ff, Gen, Lzd, Pen, Tr, Sulfatrim, Sulfamycin,