Table 1
Mean values and standard deviation of heart rate (HR), respiratory rate (f), mean arterial pressure (MAP), expired fraction of carbon dioxide (EtCO2), peripheral oxygen saturation (SpO2), expired fraction of isoflurane (EtISO), and body temperature (Tc) of female dogs initially premedicated with acepromazine (0.05 mg/kg), induced with propofol (4 mg/kg), and maintained under inhalation anesthesia with isoflurane (1.4 V%) (M0). After administering fentanyl (2.5 µg/kg bolus followed by 15 µg/kg/h continuous infusion [CI]) (GF, n = 10) or remifentanil (bolus of 0.9% saline solution followed by 18 µg/kg/h CI) (GR, n = 10), all parameters were recorded at M15, M30, M45, M60, M75, M90, M105, and M120, i.e., every 15 min. During these moments, the animals remained unstimulated, and isoflurane was adjusted to maintain the animals in the plane 2 of Stage III, according to Guedel’s classification.
Table 2
Mean values and standard deviation of hydrogen potential (pH), arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2), arterial oxygen saturation (SaO2), serum bicarbonate concentration (HCO3), and base deficit (BD) of female dogs initially premedicated with acepromazine (0.05 mg/kg), induced with propofol (4 mg/kg), and maintained under inhalation anesthesia with isoflurane (1.4 V%) (M0). After the administration of fentanyl (2.5 µg/kg bolus followed by 15 µg/kg/h continuous infusion [CI]) (GF, n = 10) or remifentanil (a bolus of 0.9% saline solution followed by 18 µg/kg/h CI) (GR, n = 10), all parameters were recorded at M15, M45, M75, and M120 at 15, 45, 75, and 120 min after baseline (M0), respectively. During these moments, the animals remained unstimulated, and isoflurane was adjusted to maintain the animals in plane 2 of Stage III, according to Guedel’s classification.
Table 3
Mean values and standard deviation of heart rate (HR), respiratory rate (f), mean arterial pressure (MAP), expired fraction of carbon dioxide (EtCO2), peripheral oxygen saturation (SpO2), expired fraction of isoflurane (EtISO), body temperature (Tc), and flow rate of fentanyl or remifentanil (µg/kg/h) (CI rate) in female dogs initially premedicated with acepromazine (0.05 mg/kg), induced with propofol (4 mg/kg), and maintained under inhalation anesthesia with isoflurane, which was adjusted to maintain the animals in plane 2 of Stage III, according to Guedel’s classification. Then, fentanyl (2,5 µg/kg bolus followed by 15 µg/kg/h continuous infusion [CI]) (GF, n = 10) or remifentanil (a bolus of 0.9% saline solution followed by 18 µg/kg/hCI) (GR, n = 10) (M120) was administered. Subsequently, the surgical procedure was performed: celiotomy (M1), followed by clamping of the right ovarian pedicle (M2), clamping of the left ovarian pedicle (M3), clamping of the cervix (M4), myorrhaphy (M5), and dermorrhaphy (M6).
Table 4
Number of animals female dogs undergoing elective ovariohysterectomythat received rescue analgesics at 30, 60, 120, 180, 240, 300, and 360 min after extubation. Then, fentanyl (2.5 µg/kg bolus followed by 15 µg/kg/h continuous infusion [CI]) (GF, n = 10) or remifentanil (a bolus of 0.9% saline solution followed by 18 µg/kg/h CI) (GR, n = 10) was administered. Opioid infusion was administered for 120 min before surgery without any stimulus as well as during the surgical procedure. The animals were administered with rescue analgesics when they scored ≥6 points on the short form of the Glasgow Composite Pain Scale (GCS).
Table 5
Mean values and standard deviation of GCS scores at 30, 60, 120, 180, 240, 300, and 360 min after extubation of animals undergoing elective ovariohysterectomy with administration of fentanyl (2.5 µg/kg bolusfollowed by 15 µg/kg/h continuous infusion [CI]) (GF, n = 10) or remifentanil (a bolus of 0.9% saline solution followed by 18 µg/kg/h CI) (GR, n = 10). Opioid infusion was administered for 120 min before surgery without any stimulus as well as during the surgical procedure. The animals received postoperative rescue analgesics when they scored ≥ 6 points on the GCS.
